The Center for Research on Influenza Pathogenesis (CRIP) is one of five Centers of Excellence for Influenza Research and Surveillance funded by the National Institute of Allergy and Infectious Diseases (NIAID). Influenza viruses are important human pathogens, infecting up to 500 million people annually worldwide, with the most severe pandemic leading to an estimated 40 million fatalities.
CRIP comprises a domestic and international animal influenza virus surveillance network combined with research on pathogenesis and host response. We bring together experts from diverse fields including virology, immunology, molecular biology, veterinary medicine, ornithology, and bioinformatics plus several leaders in influenza virus research. Our surveillance network spans all continents, allowing worldwide sampling and isolation of animal and human influenza viruses and early detection of emerging viruses that may cause pandemic threats. Through our research program, our scientists dedicate themselves to understanding influenza virus animal reservoirs, evolution, transmission and adaptation to humans as well as pathogenesis, evasion of immunity, and induction of host and vaccine responses.
The Center also serves as a resource to the scientific community. We provide a repository for viral isolates, serum samples, antibodies, purified proteins, and reagents through Biodefense and Emerging Infections Resources (BEI) as well as access to viral sequence analysis and phylogenetics through the Influenza Research Database (IRD).