Center for Neurotechnology and Behavior

Seeing The Unseen Brain

The Center for Neurotechnology and Behavior at the Icahn School of Medicine at Mount Sinai employs revolutionary technologies to improve how we understand the brain. Where once we could only glimpse at neural activity, we now implement tools that reveal the intricate workings of neural circuits with clarity. Multiphoton microscopy peers deep into brain tissues with minimal damage, visualizing neurons that were once invisible. Miniaturized cameras allow us to capture neural activity in freely moving animals, revealing natural brain function without restraints. Through photonic chemistry, we have created optical biosensors that can detect the release of neuromodulators in living brains—tracking chemical messengers central to mood and cognition. These are just a few of the approaches our scientists use to understand and treat complex neurological and psychiatric disorders.

At the heart of the Center is a collaborative approach that brings together experts across multiple disciplines. Our faculty members work in concert across five key technological domains—imaging, electrophysiology, genetics, circuit manipulation, and behavioral research—to study neural circuits involved in addiction, anxiety, depression, and Alzheimer's disease. This integration of technology with cross-disciplinary expertise drives discoveries that reach beyond the laboratory.

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MEET THE DIRECTOR

Paul Slesinger, PhD

PROFESSOR | Neuroscience

PROFESSOR | Pharmacological Sciences

VICE CHAIR FOR NASH DEPARTMENT OF NEUROSCIENCE | Neuroscience

Dr. Slesinger is a distinguished neuroscientist whose research primarily focuses on discovering new drugs for treating addiction to drugs and alcohol.

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AT A GLANCE

Publications

344

Press/Media

18 Researchers

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Recent Publications

A comprehensive suite for extracting neuron signals across multiple sessions in one-photon calcium imaging. Nature Communications

Cocaine-context memories are transcriptionally encoded in nucleus accumbens Arc ensembles. Nature Communications

Cocaine-induced gene regulation in D1 and D2 neuronal ensembles of the nucleus accumbens. Communications Biology

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Our Team

Abha K Rajbhandari, PhD

Assistant Professor | Psychiatry

Deanna L Benson, PhD

Professor | Neuroscience

Denise Cai, PhD

Associate Professor | Neuroscience

George W Huntley, PhD

Professor | Neuroscience

Eric J Nestler, MD, PhD

Interim Dean, Icahn School of Medicine at Mount Sinai

Hala Nicolas, PhD

Associate Professor | Psychiatry

Hirofumi Morishita, MD, PhD

Professor | Psychiatry

Ian S Maze, PhD

Professor | Neuroscience

Paul J Kenny, PhD

Ward-Coleman Professor and Chair of the Nash Family Department of Neuroscience

Paul Slesinger, PhD

Lillian and Henry M. Stratton Professor of Neuroscience; Director, Center for Neurotechnology and Behavior; Vice Chair, Nash Family Department of Neuroscience at Mount Sinai