Allergy and Immunology Research

All fellows have many opportunities for research as we believe that solid research experiences are essential to our fellowship training. Common areas of research include: primary immunodeficiency, food allergy, chronic urticaria, drug allergy, and asthma. Our fellows collaborate extensively with other physicians and departments on numerous research projects, ensuring that fellows can be involved with several projects.

To read more about the ongoing basic science and clinical research in the Division of Clinical Immunology, please click here

The laboratories supervised by the full-time faculty focus primarily on immunologic mechanisms and disorders; some of the major areas of interest currently include:

  • B and T cell growth and differentiation
  • Control mechanisms of immunoglobulin production
  • Mucosal immunology
  • Genetics of B cell diseases
  • B cell activation by TLR agonists
  • Bioinformatics of allergic diseases
  • Asthma in aging
  • Anaphylaxis
  • Computer analysis of immune deficiency states
  • Food protein induced enterocolitis syndrome (FPIES)
  • Eosinophilic esophagitis
  • Novel therapies for food allergies
  • Allergen characterization – B cell epitopes
  • Antigen-presenting cells in food allergy
  • T cell immunophenotypic changes secondary to immunotherapy in food allergy
  • Basophil activation assays
  • Murine models of food allergy and immunotherapy

Clinical Trials and Other Research Experiences

  • Role of estrogen in bradykinin production and degradation
  • Studying the treatment of hyper-eosinophilic syndromes using anti-IL5 monoclonal antibodies
  • Use of a subcutaneous plasma kallikrien inhibitor for hereditary angioedema prophylaxis
  • Investigating the use of Chinese herbal medicines for the treatment of food allergies
  • Studying the use of oral immunotherapy to treat milk egg and peanut allergy as well as multiple food allergies
  • Epicutaneous immunotherapy for food allergies
  • Investigating of the mechanism of outgrowing allergy, in particular, tolerance to heated milk and egg
  • Investigating the mechanism and treatment of food protein induced enterocolitis syndrome (FPIES)
  • Therapies for eosinophilic esophagitis
  • Investigating genetic causes of antibody deficiencies by whole exome Sequencing
  • Building a Registry of Patients with Primary Immune Deficiency (USIDNET)
  • Studying development of memory B cells in CVID
  • Examining IgA in mucosal Immunity
  • Examining the role of serum IgM
  • Developing computer targeting methods to identify immunodeficiencies in minorities
  • Studying the use of immunomodulators in immune dysregulation diseases
  • Investigation of the biomarker serum periostin in allergic rhinitis and chronic rhinosinusitis with nasal polyposis

Click here to see a list of publications by our current and past fellows.