Nash Family Center for Advanced Circuit Therapeutics

Mission: To advance precision neurosurgical treatments for complex neuropsychiatric disorders through the rapid translation of neuroscience and neuroengineering innovations.

Vision: A shared ecosystem of clinicians, neuroscientists and engineers will catalyze a new model of patient-focused research with the common goal to correct circuit abnormalities and restore mood, motor and cognitive function across diagnoses.

For too many patients struggling with the daily challenges of a psychiatric or neurologic disorder, today’s therapies simply aren’t enough. The Nash Family Center for Advanced Circuit Therapeutics is committed to developing bold, new approaches for the treatment of conditions from major depression and addiction to eating disorders and post-traumatic stress syndrome to movement disorders and epilepsy as well.

Our research looks beyond pharmacological therapies to instead focus on understanding and correcting the circuit-based mechanisms of these diseases. Combining innovative technologies (including deep brain stimulation and advanced imaging) with the experience of a multidisciplinary team (including researchers and clinicians in neurology, neurosurgery, psychiatry, and radiology), our Center is working toward the day when precision, circuit-based treatments help patients to finally move beyond their condition and enjoy life to the fullest.

About Us

At a time when the field of neuroscience is being revolutionized by innovative technologies and transformative discoveries in genetics and molecular and cell biology, the Nash Family Center for Advanced Circuit Therapeutics is committed to harnessing the power of this progress for patients with a range of psychiatric and neurologic diseases. Under the guidance of founding director Helen S. Mayberg, MD, our interdisciplinary Center synthesizes the skills of our research team with the insights of our clinical colleagues in order to rethink the way treatments are discovered, personalized, and delivered to patients.

As new tools present fresh paradigms for understanding neuropsychiatric disorders based on the brain’s electric circuitry, our Center’s work focuses on deep brain stimulation (DBS), a pioneering neurosurgical procedure for several movement disorders that also holds potential for a greater range of conditions, including depression, addiction, eating disorders, schizophrenia, anxiety disorders, and post-traumatic stress syndrome. As opposed to today’s pharmacological therapies—which address symptoms but not the cause—DBS offers the possibility of modifying the circuit-based mechanisms of these conditions for patients who have exhausted all other treatments.

Located in a new building at Mount Sinai West—home to premier surgical facilities—our Center’s physical layout reflects its interdisciplinary and translational mission and intends to shake up the scientific status quo. Our blueprint places research laboratories in the patient care environment, encouraging direct interaction of research and clinical personnel and providing unprecedented opportunities for immediate testing of common disease mechanisms and circuit-tuning strategies. In collaboration with the Center for Neuromodulation, Bonnie and Tom Strauss Movement Disorders Center, The Depression and Anxiety Center for Discovery and TreatmentMovement Disorders CenterThe Epilepsy Center, The BioMedical Engineering and Imaging Institute (BMEII) and The Friedman Brain Institute this one-of-a-kind clinical and research hub works daily to translate research into personalized treatments, to correct brain circuit abnormalities for improved mood, motor, and cognitive functioning, and to maximize long-term outcomes.

By challenging traditional approaches to diagnosis, treatment, and collaboration, the Nash Family Center for Advanced Circuit Therapeutics is committed to discovering more precise, individualized treatments in order to improve the lives of countless patients with advanced neuropsychiatric disorders.


Clinical Trial

Electrophysiological Biomarkers to Optimize Deep Brain Stimulation for Depression
The Icahn School of Medicine at Mount Sinai is running a single-center experimental trial of deep brain stimulation (DBS) to the subcallosal cingulate region (Area 25) for treatment resistant depression (TRD). The goal of this study is to refine and optimize this treatment approach using a newly available neuromodulation system (the Medtronic Summit RC+S) that allows brain activity during ongoing therapeutic DBS to be recorded from the brain in real-time. This study will further define brain readouts that track depression recovery, providing novel strategies to monitor and guide treatment and device programming decisions in patients receiving DBS for TRD.
Participating Mount Sinai Programs:
Depression and Anxiety Center for Discovery and Treatment (DAC)
Center for Neuromodulation
Nash Family Center for Advanced Circuit Therapeutics
To enroll in the study, please contact Emma Meyer at 212-241-6539 or
For more information visit Mount Sinai Clinical Trials.