The physicians and scientists in the Department of Medicine are continuously making discoveries and providing insights that have a significant impact on science, medicine and, ultimately, people’ lives. Their research and medical expertise are recognized in prestigious academic journals as well as the mainstream press and social media outlets. The Department of Medicine has multiple platforms to highlight and share their medical breakthroughs, advice and recommendations.

Please read some of DOM’s latest academic research publications:

P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes, by Peter Heeger, et al, Journal of Clinical Investigation

Association of a bundled hospital-at-home and 30-day postacute transitional care program with clinical outcomes and patient experiences, by Alex Federman, Linda DeCherrie, et al., JAMA Internal Medicine

Diabetes Technology Use among Pregnant and Nonpregnant Women with T1D in the T1D Exchange, by Carol Levy, MD, et al., Diabetes Technology and Therapeutics

Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth, by Weijia Zhang, et al., Proceedings of the National Academy of Sciences of the United States of America

Direct-acting antiviral treatment of acute hepatitis C virus infections (Review), by Douglas Dieterich, Benham Saberi, Tatyana Kushner, Suresh Misra, Expert Review of Anti-Infective Therapy

An Evaluation of the Collagen Fragments Related to Fibrogenesis and Fibrolysis in Nonalcoholic Steatohepatitis, by Amon Asgharpour, et al, Scientific Reports

Overdiagnosis in primary care: Framing the problem and finding solutions(Review), by Minal Kale, et al., BMJ (Online)

Clinical Exposure to Transgender Medicine Improves Students' Preparedness above Levels Seen with Didactic Teaching Alone: A Key Addition to the Boston University Model for Teaching Transgender Healthcare, by Joshua Safer, et al., Transgender Health

Yeast Infections in Solid Organ Transplantation(Review), by Sarah Taimur, Infectious Disease Clinics of North America

Chapters: Tools in the art of studying necroptosis, Analysis of necroptosis in bone marrow-derived macrophages, Detection of RIPK1 in the FADD-containing death inducing signaling complex (DISC) during necroptosis, Analysis of CYLD proteolysis by CASPASE 8 in bone marrow-derived macrophages, by Adrian Ting, PhD, Methods in Molecular Biology

Interleukin 33 regulates gene expression in intestinal epithelial cells independently of its nuclear localization, by Sergio Lira, Glaucia Furtado, Lili Chen, Zhengxiang He, Cytokine

High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue, by Meriam Merad, et al, Mucosal Immunology

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals, by Girish Nadkarni, et al, Nature Communications

Cross-sex hormones and acute cardiovascular events in transgender persons: A cohort study, by Joshua Safer, et al., Annals of Internal Medicine

Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity, by Andrew Stewart, Peng Wang, et al, European Journal of Medicinal Chemistry

Huntingtin-interacting protein 1 (HIP1) regulates arthritis severity and synovial fibroblast invasiveness by altering PDGFR and Rac1 signalling, by Percio Gulko, Teresa Laragione, et al., Annals of Rheumatic Diseases

Small-for-size Syndrome Does Not Occur in Intestinal Transplantation Without Liver Containing Grafts, by Thomas Schiano, et al., Transplantation

Establishing a Core Outcome Measure for Graft Health: A Standardized Outcomes in Nephrology-Kidney Transplantation (SONG-Tx) Consensus Workshop Report, by Barbara Murphy, et al., Transplantation

Treating depression in an urban primary care setting: Introducing an adapted therapeutic approach to improve behavioral health engagement in primary care, by Lauren Peccoralo, et al., Social Work in Health Care

Impact of preformed T-cell alloreactivity by means of donor-specific and panel of reactive T cells (PRT) ELISPOT in kidney transplantation, by Paolo Cravedi, et al., PLoS One

Molecular therapies and precision medicine for hepatocellular carcinoma, by Joseph Llovet, Daniela Sia, et al., Nature Reviews Clinical Oncology

High-density single cell mRNA sequencing to characterize circulating tumor cells in hepatocellular carcinoma, by Augusto Villanueva, et al., Scientific Reports

Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation, by Donald Scott, Dirk Homann, Adolfo Garcia-Ocana, Liora Katz, et al., Diabetes.

Organs from deceased donors with false-positive HIV screening tests: An unexpected benefit of the HOPE act, by Shirish Huprikar, et al., American Journal of Tranpslantation

Accelerated infliximab dosing increases 30-day colectomy in hospitalized ulcerative colitis patients: A propensity score analysis, by Shailja Shah, Steven Naymagon, Bruce Sands, Benjamin Cohen, Marla Dubinsky, Inflammatory Bowel Diseases

CCR8 is expressed by post-positive selection CD4-lineage thymocytes but is dispensable for central tolerance induction, by Sergio Lira, et al., PLoS ONE

International validation of the thrombolysis in myocardial infarction (TIMI) risk score for secondary prevention in post-mi patients: A collaborative analysis of the chronic kidney disease prognosis consortium and the risk validation scientific committee, by Girish Nadkarni, et al., Journal of the American Heart Association

Current Guideline Controversies in the Management of Pancreatic Cystic Neoplasms, by Christopher DiMaio, Gastrointestinal Endoscopy Clinics of North America

Hemochromatosis: pathophysiology, evaluation, and management of hepatic iron overload with a focus on MRI, by Ilan Weisberg, et al. Expert Review of Gastroenterology and Hepatology

How Co-Creation Helped Address Hierarchy, Overwhelmed Patients, and Conflicts of Interest in Health Care Quality and Safety, by Harry Cho, Sigal Israilov, AMA Journal of Ethics

(Can't Get No) Patient Satisfaction the Predictive Power of Demographic, GI, and Psychological Factors in IBS Patients, by Laurie Keefer, et al., Journal of Clinical Gastroenterology

Expression of Endothelial Cell Injury Marker Cd146 Correlates with Disease Severity and Predicts the Renal Outcomes in Patients with Diabetic Nephropathy, by Cijiang He, et al., Cellular Physiology and Biochemisty

Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses, by Charlotte Cunningham-Rundles, Paul Maglione, et al., Journal of Allergy and Clinical Immunology

Higher Growth Rate of Branch Duct Intraductal Papillary Mucinous Neoplasms Associates With Worrisome Features, by Aimee Lucas, Michelle K. Kim, Nikhil Kumta, Satish Nagula, Christopher DiMaio, et al., Clinical Gastroenterology and Hepatology

Trends of Earlier Palliative Care Consultation in Advanced Cancer Patients Receiving Palliative Radiation Therapy, by Juan Wisnivesky, Keith Sigel, et al., Journal of Pain and Symptom Management

Molecular mechanisms of proteinuria in focal segmental glomerulosclerosis, by Kirk Campbell, et al., Frontiers in Medicine

Biological Variability of Estimated GFR and Albuminuria in CKD, by Ilse Daehn, et al., American Journal of Kidney Diseases

Mechanisms of NAFLD development and therapeutic strategies (Review), by Scott Friedman, et al., Nature Medicine

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries, by Girish Nadkarni, et al., Nature Communications

PTK6 regulates growth and survival of endocrine therapyresistant ER+ breast cancer cells, by Weijia Zhang, et al, NPJ Breast Cancer

Identification of microR-106b as a prognostic biomarker of p53-like bladder cancers by ActMiR, by William Oh, Mathew Galsky, et al., Oncogene

Self-management behaviors in World Trade Center rescue and recovery workers with asthma, by Juan Wisnivesky, Jeffrey Weiss, et al., Journal of Asthma

The enigmatic function of IgD: some answers at last, by Andrea Cerutti, et al., European Journal of Immunology

Providing Mental Health Services in the Primary Care Setting: the Experiences and Perceptions of General Practitioners at a New York City Clinic, by Lauren Peccoralo, et al., Psychiatric Quarterly

Luminally polarized mural and vascular remodeling in ileal strictures of Crohn's disease, by Bruce Sands, Jean-Frederic Colombel, Judy Cho, Noam Harpaz, et al., Human Pathology

Mechanisms of NAFLD development and therapeutic strategies, by Scott Friedman, et al., Nature Medicine

Serum 6-Bromotryptophan Levels Identified as a Risk Factor for CKD Progression, by Girish Nadkarni, et al., Journal of the American Society of Nephrology

De-escalation of Therapy in Inflammatory Bowel Disease, by Jean-Frederic Colombel, et al., Current Gastroenterology Reports

Inotersen treatment for patients with Hereditary transthyretin amyloidosis, by Peter Gorevic, et al., New England Journal of Medicine

Consecutive negative findings on colonoscopy during surveillance predict a low risk of advanced neoplasia in patients with inflammatory bowel disease with long-standing colitis: Results of a 15-year multicentre, multinational cohort study, by Steven Itzkowitz, Shajila Shah, Dan Castaneda, Jean-Frederic Colombel, et al., Gut

EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment, by David Volsky, Alejandra Borjabad, Jennifer Kelschenbach, Boe Hyun Kim, Mary Jane Potash et al., PLoS Pathogens

Improvement in Gastrointestinal Symptoms After Cognitive Behavior Therapy for Refractory Irritable Bowel Syndrome, by Laurie Keefer, et al., Gastroenterology

Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development, by Weijia Zhang, et al., Journal of Biological Chemistry

A Population-Based Cohort Analysis of Chemoradiation Versus Radiation Alone for Definitive Treatment of Stage I Anal Cancer in Older Patients, by Juan Wisnivesky, Michael Gaisa, Keith Sigel, et al., Diseases of the Colon and Rectum

CDG: An online server for detecting biologically closest disease-causing genes and its application to primary immunodeficiency, by Charlotte Cunningham-Rundles, et al., Fronteirs in Immunology

CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity, by Yujin Hoshida, et al., Gut

IPSC-derived familial Alzheimer's PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling, by Christoph Buettner, et al., Molecular Neurodegeneration

Identification of Endpoints for Development of Antifibrosis Drugs for Treatment of Crohn's Disease, by Bruce Sands, Jean Frederic Colombel, et al., Gastroenterology

Vedolizumab for Ulcerative Colitis: Treatment Outcomes from the VICTORY Consortium, by Bruce Sands, Jean-Frederic Colombel, et al., American Journal of Gastroenterology

Chronic Cough Related to Acute Viral Bronchiolitis in Children, by Sidney Braman, et al., Chest

Benefits and harms of lung cancer screening in HIV-infected individuals with CD4+ cell count at least 500 cells/μl, by Juan Wisnivesky, Keith Sigel, et al., AIDS

Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects, by Charlotte Cunningham-Rundles, et al., Journal of Allergy and Clinical Immunology

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population, by Judy Cho, et al., PLoS Genetics

PRO (“The Window Is Open”): In patients with cirrhosis with prior variceal hemorrhage and ascites, the clinical benefits of nonselective beta-blockers outweigh the risks and should be prescribed, by Thomas Schiano, et al., Clinical Liver Disease

Soluble levels of receptor for advanced glycation endproducts and dysfunctional high-density lipoprotein in persons infected with human immunodeficiency virus, by Judith Aberg, et al., Medicine

Vagal dysfunction and small intestinal bacterial overgrowth: Novel pathways to chronic inflammation in HIV, by Saurabh Mehandru, et al., AIDS

NPHP1 (Nephrocystin-1) gene deletions cause adult-onset ESRD, by Weijia Zhang, Barbara Murphy, et al., Journal of the American Society of Nephrology

Gene expression profiles of glomerular endothelial cells support their role in the glomerulopathy of diabetic mice, by Weijia Zhang, Cijiang He, Peter Chuang, Detlef Schlondorff, et al., Kidney International

Small-molecule activators of protein phosphatas 2A for the treatment of castration-resistant prostate cancer, by William Oh, Matthew Galsky, et al., Cancer Research

The short-term incidence of hepatocellular carcinoma is not increased after hepatitis C treatment with direct-acting antivirals: An ERCHIVES study, by Daniel Fierer, et al., Hepatology

Multimethod assessment of baseline depression and relationship to hepatitis C treatment discontinuation, by Jeffrey Weiss, Sarah Prieto, Douglas Dieterich, et al., International Journal of Psychiatry in Medicine

Magnetic resonance imaging predicts histopathological composition of ileal Crohn's disease, by Jean-Frederic Colombel, Judy Cho, et al., Journal of Crohn’s and Colitis

High Risk of Advanced Colorectal Neoplasia in Patients With Primary Sclerosing Cholangitis Associated With Inflammatory Bowel Disease, by Jean-Frederic Colombel, Steven Itzkowitz, Joana Torres, Shajila Shah, et al., Clinical Gastroenterology and Hepatology

Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue, by Susan Fried, et al., PLoS ONE

National Trends and Outcomes in Dialysis-Requiring Acute Kidney Injury in Heart Failure: 2002–2013, by Lili Chan, Girish Nadkarni, Ashish Correa, et al., Journal of Cardiac Failure

Increased Airway Wall Thickness is Associated with Adverse Longitudinal First–Second Forced Expiratory Volume Trajectories of Former World Trade Center workers, by Juan Wisnivesky, et al., Lung

A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer, by Yujin Hoshida, Scott Friedman, et al., Journal of Hepatology

The complement system and C1q in chronic hepatitis C virus infection and mixed cryoglobulinemia (Review), by Ahmed el-Shamy, Andrea Bramch, Thomas Schiano, Peter Gorevic, Frontiers in Immunology 

Enrichment and characterization of cancer stem-like cells in ultra-low concentration of serum and non-adhesive culture system, by Huabao Xiong, et al., American Journal of Translational Research

Long-term efficacy and safety of ustekinumab for Crohn's disease through the second year of therapy, by Bruce Sands, Jean-Frederic Colombel, et al., Alimentary Pharmacology and Therapeutics

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host, by Sergio Lira, Glaucia Furtado, et al., Nature

Mast cell–dependent CD8þ T-cell recruitment mediates immune surveillance of intestinal tumors in ApcMin/þ Mice, by Sergio Lira, et al., Cancer Immunology Research

National patterns of physician management of sleep apnea and treatment among patients with hypertension, by David Rapoport, et al., PLoS ONE

Actions of pituitary hormones beyond traditional targets(Review), by Mone Zaidi, Terry Davies, et al., Journal of Endocrinology

Fully Closed-Loop Multiple Model Probabilistic Predictive Controller Artificial Pancreas Performance in Adolescents and Adults in a Supervised Hotel Setting, by Carol Levy, David Lam, Camilla Levister, et al., Diabetes Technology and Therapeutics

Facilitators and Barriers to Oncologists’ Conduct of Goals of Care Conversations, by Jenny Lin, Cardinale Smith, et al., Journal of Palliative Care

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease, by Sidney Braman, et al., Journal of Allergy and Clinical Immunology

Outcomes of sequential treatment with sorafenib followed by regorafenib for HCC: Additional analyses from the phase III RESORCE trial, by Charissa Chang, et al., Journal of Hepatology

Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment, by Jenny Wong, Kirk Campbell, Lewis Kaufman, et al., Nature Communications

Ethico-Legal Challenges of Drug Packing—A Case Report, by Paru Patrawalla, et al., American Journal of Medicine

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes, Percio Gulko, Teresa Laragione, Nature Communications

High Risk of Advanced Colorectal Neoplasia in Patients With Primary Sclerosing Cholangitis Associated With Inflammatory Bowel Disease, by Jean-Frederic Colombel, Steven Itzkowitz, et al., Clinical Gastroenterology and Hepatology

Advances in drug discovery for human beta cell regeneration, by Andrew Stewart, et al., Diabetologia

Reduced cell-associated DNA and improved viral control in macaques following passive transfer of a single anti-V2 monoclonal antibody and repeated simian/human immunodeficiency virus challenges, by Susan Zolla-Pazner, Rebecca Powell, et al., Journal of Virology

National Landscape of Unplanned 30-Day Readmissions in Patients With Left Ventricular Assist Device Implantation, by Lili Chan, Girish Nadkarni, et al., American Journal of Cardiology

Hereditary angioedema from the patient's perspective: A follow-up patient survey, by Paula Busse, et al., Allergy and Asthma Proceedings

A characterization of pro-inflammatory cytokines in dextran sulfate sodium-induced chronic relapsing colitis mice model, by Jean-Frederic Colombel, Adam Rosenstein, et al., International Immunopharmacology

Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease, by Jean-Frederic Colombel, et al, Cochrane Database of Systematic Reviews

Pneumatosis Intestinalis Associated with the Tyrosine Kinase Inhibitor Nintedanib, by Sidney Braman, Armeen Poor, Lung

Eighth edition staging of thoracic malignancies: Implications for the reporting pathologist, by Charles Powell, et al, Archives of Pathology and Laboratory Medicine

Co-Care: A Registry for Individuals at Increased Risk for Colorectal Cancer, by Steven Itzkowitz, et al., Journal of Registry Management

Quality of Life in Inflammatory Bowel Disease: A Systematic Review and Meta-analyses - Part II, by Laurie Keefer, et al., Inflammatory Bowel Diseases

Protein S protects against podocyte injury in diabetic nephropathy, by Cijiang He, Kyung Lee, Peter Chuang, et al., Journal of the American Society of Nephrology

Disseminated Cutaneous Warts in X-Linked Hyper IgM Syndrome, by Charlotte Cunningham-Rundles, et al, Journal of Clinical Immunology

Biomarkers of AKI progression after pediatric cardiac surgery, by Steven Coca, et al, Journal of the American Society of Nephrology

OP449 inhibits breast cancer growth without adverse metabolic effects, by Emily Gallagher, Derek LeRoith, et al, Endocrine-related Cancer

Systematic review and meta-analysis: Preoperative vedolizumab treatment and postoperative complications in patients with inflammatory bowel disease, by Jean-Frederic Colombel, et al., Journal of Crohn’s and Colitis

Thiopurines in inflammatory bowel disease: New findings and perspectives (Review), by Jean-Frederic Colombel, et al., Journal of Crohn’s and Colitis

Systematic review: Safety of mesalazine in ulcerative colitis, by Jean-Frederic Colombel, et al., Alimentary Pharmacology and Therapeutics

Charter on Physician well-being, by Jonathan Ripp, et al., Journal of the American Medical Association

Generation and characterization of a bivalent protein boost for future clinical trials: HIV-1 subtypes CR01_AE and B gp120 antigens with a potent adjuvant, by Susan Zolla-Pazner, et al., PLoS ONE

Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects, by Alison Lee, Sonai Bose, et al., Respiratory Research

Asthma Over the Age of 65: All's Well That Ends Well, by Paula Busse, et al., Journal of Allergy and Clinical Immunology: In Practice

Urinary peptides as a novel source of T cell Allergen Epitopes, by Paula Busse, et al., Frontiers in Immunology

Pharmacokinetics of Intranasal versus Subcutaneous Insulin in the Mouse, by David Volsky, et al., ACS Chemical Neuroscience

Plasma biomarkers are associated with renal outcomes in individuals with APOL1 risk variants, by Girish Nadkarni, Erwin Bottinger, Steve Coca, et al., Kidney International.

Low-dose valganciclovir for cytomegalovirus prophylaxis in intermediate-risk liver transplantation recipients, by Timothy Sullivan, Dallas Dunn, Gopi Patel, Shirish Huprikar, et al., Liver Transplantation

Profile of apalutamide in the treatment of metastatic castration-resistant prostate cancer: Evidence to date (Review) by William Oh, et al., OncoTargets and Therapy

The prognostic importance of duration of AKI: A systematic review and meta-analysis (Review), by Girish Nadkarni, Steve Coca, et al., BMC Nephrology

When Do You Start and When Do You Stop Screening for Colon Cancer in Inflammatory Bowel Disease?, by Bruce Sands, et al., Clinical Gastroenterology and Hepatology

What Is the Role of the Inflammatory Bowel Disease Panel in Diagnosis and Treatment?, by Bruce Sands, et al., Clinical Gastroenterology and Hepatology

Understanding the tumor immune microenvironment (TIME) for effective therapy, by Meriam Merad, et al., Nature Medicine

Urbanization and the gut microbiota in health and inflammatory bowel disease, by Jean-Frederic Colombel, et al., Nature Reviews Gastroenterology and Hepatology.

Dual paraneoplastic endocrine syndromes heralding onset of extrapulmonary small cell carcinoma: A case report and narrative review, by Jill Feffer, Natalia Branis, Jeanine Albu, Frontiers in Endocrinology

Associations of Residential Socioeconomic, Food, and Built Environments with Glycemic Control in Persons with Diabetes in New York City from 2007-2013, by Carol Horowitz, Victoria Mayer, et al., American Journal of Epidemiology

Hyperinsulinemia promotes esophageal cancer development in a surgically-induced duodeno-esophageal reflux murine model, by Emily Gallagher, Derek LeRoith, et al., International Journal of Molecular Sciences

Noninvasive prediction of portal pressure with MR elastography and DCE-MRI of the liver and spleen: Preliminary results, by Thomas Schiano, et al., Journal of Magnetic Resonance Imaging

The prevalence and significance of Staphylococcus aureus in patients with non-cystic fibrosis bronchiectasis, by Edward Eden, Gerald Turino, et al., Annals of the American Thoracic Society

Pathway for the management of hyperglycemia in the cardiac care unit, by Jeanine Albu, Eyal Herzog, Seyed Dehkordi, et al., Critical Pathways in Cardiology

Feasibility and safety of microforceps biopsy in the diagnosis of pancreatic cysts, by Christopher DiMaio, et al., Gastrointestinal Endoscopy

Efficacy and Safety of Digital Single-Operator Cholangioscopy for Difficult Biliary Stones, by Christopher DiMaio, Nikhil Kumta, et al., Clinical Gastroenterology and Hepatology.

Adverse drug events and medication problems in “Hospital at Home” patients, by Alex Federman, et al., Home Health Care Services Quarterly

Right Care in Hospital Medicine: Co-creation of Ten Opportunities in Overuse and Underuse for Improving Value in Hospital Medicine, by Harry Cho, Surafel Tsega, et al., Journal of General Internal Medicine

Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice, by David Volsky, Mary Jane Potash, et al., Journal of NeuroVirology

Central nervous system histoplasmosis, by Shirish Huprikar, et al., Medicine

A Palliative Radiation Oncology Consult Service's Impact on Care of Advanced Cancer Patients, by Juan Wisnivesky, et al., Journal of Palliative Medicine

Lysosomal acid lipase deficiency allograft recurrence and liver failure- clinical outcomes of 18 liver transplantation patients, by Thomas Schiano, et al., Molecular Genetics and Metabolism

CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH-associated neurodegeneration and mass lesions, by Sergio Lira, Miriam Merad, et al., Cancer

Assessment of atherosclerotic plaque activity in patients with sleep apnea using hybrid positron emission tomography/magnetic resonance imaging (PET/MRI): a feasibility study, by Neomi Shah, et al., Sleep and Breathing

Obstructive sleep apnea severity affects amyloid burden in cognitively normal elderly: A longitudinal study, by David Rapoport, Andrew Varga, Indu Ayappa, et al., American Journal of Respiratory and Critical Care Medicine

Targeting KCa1.1 channels with a scorpion venom peptide for the therapy of rat models of rheumatoid arthritis, by Percio Gulko, Theresa Laragione, et al., Journal of Pharmacology and Experimental Therapeutics

Cost-effectiveness of hepatitis C screening and treatment linkage intervention in US methadone maintenance treatment programs, by David Perlman, et al., Drug and Alcohol Dependence

A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma, by Augusto Villanueva, Daniela Sia, Scott Friedman, Josef Llovet, Myron Schwartz, et al., Oncogene

Analysis of biomarkers within the initial 2 years posttransplant and 5-year kidney transplant outcomes: Results from clinical trials in organ transplantation-17, by Girish Nadkarni, Madhov Menon, Barbara Murphy, Peter Heeger, et al., Transplantation

T cell expression of C5a receptor 2 augments murine regulatory T Cell (TREG) generation and TREG-dependent cardiac allograft survival, by DA Verghese, Markus Demir, Nicholas Chun, Miguel Fribourg, Paolo Cravedi, Ines Llaudo, Pradya Yadav, Sergio Lira, Madov Menon, Peter Heeger, et al., Journal of Immunology

Differences in the immune microenvironment of anal cancer precursors by HIV status and association with ablation outcomes, by Michael Gaisa, Talia Swartz, Yotam Arens, Keith Sigel, et al., Journal of Infectious Diseases

Heterogeneity in glycan composition on the surface of HIV-1 envelope determines virus sensitivity to lectins, by Muzafar Jan, Chitra Upadhyay, Caterina Hioe, et al., PLoS ONE

HIV-1 envelope glycoproteins from diverse clades differentiate antibody responses and durability among vaccines, by Susan Zolla-Pazner, et al., Journal of Virology.

Organ donor screening practices for Strongyloides stercoralis infection among US organ procurement organizations, by Shirish Huprikar, et al., Transplant Infectious Disease

Rationale and design of a randomized controlled trial of home-based primary care versus usual care for high-risk homebound older adults, by Jennifer Reckrey, Elizabeth McCormick, Linda DeCherrie, Alex Federman, et al., Contemporary Clinical Trials

A Palliative Radiation Oncology Consult Service Reduces Total Costs During Hospitalization, by Juan Wisnivesky, et al., Journal of Pain and Symptom Management

Direct-acting antiviral regimens are safe and effective in the treatment of hepatitis C in simultaneous liver–kidney transplant recipients, by James Crismale, Thomas Schiano, et al., Clinical Transplantation

ACG Clinical Guideline: Management of Crohn's Disease in Adults (review), by Bruce Sands, et al., American Journal of Gastroenterology

Biologics in allergic and immunologic diseases: Promises and challenges in the era of personalized medicine, by Mauli Desai, et al., Annals of Allergy, Asthma and Immunology

Outcomes 7 Years After Infliximab Withdrawal for Patients With Crohn's Disease in Sustained Remission, by Jean-Frederic Colombel, et al., Clinical Gastroenterology and Hepatology

Changes in insulin sensitivity over time and associated factors in HIV-infected adolescents, by Jennifer Jao, et al., AIDS.

Is it idiopathic pulmonary fibrosis or not? (Review), by Maria Padilla, Genta Ishikawa, et al., Journal of the American Board of Family Medicine.

Characterizing hospitalist practice and perceptions of critical care delivery, by Alfred Burger, et al., Journal of Hospital Medicine

Heterogeneity in glycan composition on the surface of HIV-1 envelope determines virus sensitivity to lectins, by Chita Upadhyay, Caterina Hioe, et al., PLoS ONE.

Screening recipients of increased risk donor organs: A multicenter retrospective study, by Meenakshi Rana, et al., Transplant Infectious Disease

A Prospective Multicenter Evaluation of the Accuracy of a Novel Implanted Continuous Glucose Sensor: PRECISE II, by Carol Levy, David Lam, et al., Diabetes Technology and Therapeutics

High baseline anal human papillomavirus and abnormal anal cytology in a phase 3 trial of the quadrivalent human papillomavirus vaccine in human immunodeficiency virus-infected individuals older than 26 years: ACTG 5298, by Michelle Cesepdes, et al., Sexually Transmitted Diseases

Differences in the immune microenvironment of anal cancer precursors by HIV status and association with ablation outcomes, by Michael Gaisa, Talia Swartz, Yotam Arens, Keith Sigel, et al., Journal of Infectious Diseases

What Makes a Good Endoscopic Teacher: A Qualitative Analysis, by Brijen Shah, Kamron Pourmand, et al., Journal of Surgical Education

Genetic basis of emerging vancomycin, linezolid, and daptomycin heteroresistance in a case of persistent Enterococcus faecium bacteremia by Deena Altman, et al., Antimicrobial Agents and Chemotherapy.

The Therapeutic Potential of Hyaluronan in COPD, by Gerald Turino, Shuren Ma, Yong Lin, et al., Chest

Best Practices for Physician-Scientist Training Programs: Recommendations from the Alliance for Academic Internal Medicine, by Mone Zaidi, et al., American Journal of Medicine

Bedside assessment of the necessity of daily lab testing for patients nearing discharge, by Hyung Cho, Surafel Tsega, Colin Iberti, Michelle O’Connor, et al., Journal of Hospital Medicine

Telenephrology: Providing Healthcare to Remotely Located Patients with Chronic Kidney Disease, by Cijiang He, Anita Mehrotra, Girish Nadkarni, Eric Langhoff, James Post, et al., American Journal of Nephrology.

The Management of Intestinal Penetrating Crohn's Disease (Review), by Jean-Frederic Colombel, Robert Hirten, Shailja Shah, David Sachar, Inflammatory Bowel Diseases.

Remote Patient Monitoring in IBD: Current State and Future Directions (Review), by Ashish Atreja,  Emamuzo Otobo, et al., Current Gastroenterology Reports.

Pulmonary infarction secondary to pulmonary embolism: An evolving paradigm, by David Steiger, Marjan Islam, Jason Filopei, Matthew Frank, , Navitha Ramesh, Madeline Ehrlich, Eric Bondarsky, Albert Miller, Respirology.

Benefits and Challenges of Lung Cancer Screening in Older Adults, by Juan Wisnivesky, Meytal Fabrikant, Thomas Marron, Rajwanth Veluswamy, et al. Clinical Therapeutics.

Increasing access to hepatitis C virus medications: A program model using patient navigators and specialty pharmacy to obtain prior authorization approval, by Trang Vu, Wilma Toribio, Farah Riazi, Genesis Ciprian, Nathalia Gibbs, Martha Giardina, Jocelyn Camacho, Korin Parrella, Joy Cambe, Catherine Amory, Rachel Chasen, Keith Sigel, Jeffrey Weiss, Journal of Managed Care and Specialty Pharmacy.

Palliative Care for People With Hepatocellular Carcinoma, and Specific Benefits for Older Adults, by Thomas Schiano, et al., Clincal Therapeutics.

Association of traffic air pollution and rhinitis quality of life in Peruvian children with asthma, by Sonali Bose, et al., PLoS ONE.

Step-Down Therapy for Asthma Well Controlled on Inhaled Corticosteroid and Long-Acting Beta-Agonist: A Randomized Clinical Trial, by Linda Rogers, MD, et al., Journal of Allergy and Clinical Immunology: In Practice

Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn's Disease, by Jean-Frederic Colombel, MD, et al., Gastroenterology

Heterosexual male and female disparities in HIV infection at the end of an epidemic: HIV infection among persons who inject drugs in New York City, 2001–2005 and 2011–2015, by David Perlman, MD, et al., Drug and Alcohol Dependence

Opportunistic screening for bone disease using abdominal CT scans obtained for other reasons in newly diagnosed IBD patients, by Bruce Sands, MD, et al., Osteoporosis International

Development of a novel histologic diagnostic algorithm for hepatic graft-versus-host disease, by Thomas Schiano, MD, et al., Modern Pathology

Combination of Gene Expression Signature and Model for End-Stage Liver Disease Score Predicts Survival of Patients With Severe Alcoholic Hepatitis, by Yujin Hoshida, MD, PhD, et al., Gastroenterology

Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses, by Andrea Cerutti, MD, et al., Immunity

Bariatric surgery is associated with increased risk of new-onset inflammatory bowel disease: Case series and national database study, by Ryan Ungaro, MD, Ashish Atreja, MD, Julia Torres, MD, Jean-Frederic Colombel, MD, et al., Alimentary Pharmacology and Therapeutics

Patients' and oncologists' views on family involvement in goals of care conversations, by Jenny Lin, MD, Cardinale Smith, MD, Nina Bickell, MD, et al., Psycho-Oncology

Evaluation of a patient-centered after visit summary in primary care, by Alex Federman, MD, Joseph Kannry, MD, et al., Patient Education and Counseling

Adherent-invasive Escherichia coli in inflammatory bowel disease (Review), by Jean-Frederic Colombel, MD, Robert Hirten, MD, et al., Gut

Interactions Between Diet and the Intestinal Microbiota Alter Intestinal Permeability and Colitis Severity in Mice by Jean-Frederic Colombel, MD, Ari Grinspan, MD, Jose Clemente, PhD, Meriam Merad, MD, PhD, Jerimiah Faith, PhD, et al., Gastroenterology

Brain insulin resistance in type 2 diabetes and Alzheimer disease: Concepts and conundrums (review), by Christoph Buettner, MD, PhD, Sam Gandy, MD, et al., Nature Reviews Neurology

Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment, by Satish Nagula, MD, et al., Gastrointestinal Endoscopy

Phenytoin inhibits necroptosis, by Adrien Ting, PhD, et al., Cell Death and Disease

Can an Emergency Department Observation Unit Reduce Hospital Admissions for COPD Exacerbation? by Sidney Brahman, MD, Julie Budde, MD, et al., Lung

Pilot study of living donor liver transplantation for patients with hepatocellular carcinoma exceeding Milan Criteria (Barcelona Clinic Liver Cancer extended criteria) by Josef Llovet, MD, et al., Journal of Liver Transplantation

Gonorrhea and Chlamydia Case Detection Increased When Testing Increased in a Multisite US HIV Cohort, 2004-2014
by Judith Aberg, MD, et al., Journal of Acquired Immune Deficiency Syndromes

Reassessing the safety concerns of utilizing blood donations from patients with hemochromatosis, by Adam Winter, MD, Douglas Tremblay, MD, John Mascarenhas, MD, Thomas Schiano, MD et al, in Hepatology

Long-term Outcomes of Gastroenteropancreatic Neuroendocrine Tumors, by Weiwei Chi, MD, Richard Warner, MD, Juan Wisnivesky, MD, DrPH, Michelle K. Kim, MD, PhD, in Pancreas

Practices, attitudes, and knowledge about Crohn’s disease and smoking cessation among gastroenterologists, by Benjamin Nulsen, MD, Bruce Sands, MD, MS, Brijen Shah, MD, and Ryan Ungaro, MD, in European Journal of Gastroenterology & Hepatology

Well differentiated grade 3 pancreatic neuroendocrine tumors compared with related neoplasms: A morphologic study, by Keith Sigel, MD, et al, Cancer Cytopathology

Allergen and Epitope Targets of Mouse-Specific T Cell Responses in Allergy and Asthma, by Paula J. Busse, MD, et al, Frontiers in Immunology

Single-cell profiling of peanut-responsive T cells in patients with peanut allergy reveals heterogeneous effector TH2 subsets,  Miriam Merad, MD, PhD, et al, Journal of Allergy and Clinical Immunology

Histological assessment of the liver explant in transplanted hepatitis C virus patients achieving sustained virological response with direct-acting antiviral agents, by Thomas Schiano, MD, et al, Histopathology

A case of late-onset cytomegalovirus myocarditis in an orthotopic heart transplant recipient; case report and review of the literature, by Ruben Mylvaganam, MD, Alison Glaser, MD, Noah Moss, MD and Meena Rana, MD, Diagnostic Microbiology and Infectious Disease

Genomic analysis revealed new oncogenic signatures in TP53-mutant hepatocellular carcinoma, Yujin Hoshida, MD, PhD, Frontiers in Genetics

Location-Specific Oral Microbiome Possesses Features Associated With CKD, Steven Coca, DO and Girish N. Nadkarni, MD, et al, Kidney International Reports

Low Serum IgE Is a Sensitive and Specific Marker for Common Variable Immunodeficiency (CVID), by Charlotte Cunningham-Rundles, MD, PhD, et al, Journal of Clinical Immunology

Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury, by Peter Chuang, MD, Cijiang He, MD, PhD, Kidney International

Tuberculosis after liver transplantation in a large center in New York City: QuantiFERON®-TB Gold-based pre-transplant screening performance and active tuberculosis post-transplant, by Keith Sigel, MD, Shrish Huprikar, MD, and Meena Rana, MD, et al, Transplant Infectious Disease

Cough Due to TB and Other Chronic Infections: CHEST Guideline and Expert Panel Report by Sidney Braman, MD, et al, Chest

Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice, by Miriam Merad, MD, PhD, et al, Nature Communications

The impact of donor liver allograft fibrosis on patients undergoing liver transplantation, by Thomas Schiano, MD, et al, Clinical Transplantation

Hippo pathway deficiency and recovery from heart failure after myocardial infarction: potential implications for kidney disease, by Kristen Meliambro, MD, Kirk Campbell, MD, Kidney International

The Impact of Partnership Status on Diabetes Control and Self-Management Behaviors, by Juan Wisnivesky, MD, DrPH, Lindsay Haines, MD, Natalie Coppa, BA, et al, Health Education & Behavior

Review Article: predictors of response to vedolizumab and ustekinumab in inflammatory bowel disease, by JF Colombel, MD, Ryan Ungaro, MD, et al, Alimentary Pharmacology & Therapeutics

Recommendations for Management of Endemic Diseases and Travel Medicine in Solid-Organ Transplant Recipients and Donors: Latin America (Review), by Shirish Huprikar, MD et al, Transplantation

Alterations of HIV-1 envelope phenotype and antibody-mediated neutralization by signal peptide mutations, by Chitra Upadhyay, PhD, Roya Feyzezhad, Susan Zolla-Pazner, PhD, Caterina Hioe, PhD, et al, PLoS Pathogens

Bisphenol A Promotes Hyperuricemia via Activating Xanthine Oxidase, by John Cijiang He, MD, PhD, et al, The FASEB Journal

A Roadmap for Research on Resident Well-Being by Jonathan Ripp, MD, et al, American Journal of Medicine

Case Report: Induced Lactation in a Transgender Woman, Tamar Reisman, MD and Zil Goldstein, MSN, in Transgender Health

Tofacitinib in Patients with Ulcerative Colitis: Health-Related Quality of Life in Phase 3 Randomised Controlled Induction and Maintenance Studies Bruce E Sands, MD, and others in Journal of Crohn's and Colitis

The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease, Jean-Frederic Colombel, MD, Professor, Division of Gastroenterology, and others, in United European Gastroenterology Journal

A Neoantigen Fitness Model Predicts Tumour Response To Checkpoint Blockade Immunotherapy Benjamin D. Greenbaum, MD, Assistant Professor, Medicine, Hematology and Medical Oncology, Pathology, Oncological Sciences, Icahn School of Medicine at Mount Sinai and Alexander Solovyov, MD, Assistant Professor, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai in Nature

Genetics: Towards β-cell regeneration Andrew Stewart, MD, Director of the Diabetes, Obesity, and Metabolism Institute at the Icahn School of Medicine in Nature Reviews

Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis Paula Busse, MD,  Associate Professor of Clinical Immunology at the Icahn School of Medicine at Mount Sinai, in New England Journal of Medicine.

Commensal bacteria make GPCR ligands that mimic human signalling molecules Louis Cohen, MD, Assistant Professor, Department of Medicine, Division of Gastroenterology in Nature

Identification of the Colicin V Bacteriocin Gene Cluster by Functional Screening of a Human Microbiome Metagenomic Library Louis Cohen, MD, Assistant Professor in ACS Infectious Diseases.

Biopsy transcriptome expression profiling to identify kidney transplants at risk of chronic injury: a multicentre, prospective study Barbara Murphy, MD, in The Lancet.

Please take a look at some of the latest blogs from our DOM faculty members:

When seniors start sneezing by Dr. Mauli Desai for Our Town

Managing your weight as you age by Dr. Reshmi Srinath for Our Town

Barbara Murphy, MD, Honored By Her Alma Mater in Ireland for Inside Mount Sinai

Novel Product to Help Patients at Risk for Kidney Disease for Inside Mount Sinai

Popular diets: how to digest it all by gastroenterologist Dr. Joshua Novak for Our Town

Screening for colorectal cancer by gastroenterologist Dr. Pascale White for Our Town

Confronting flu season by infectious disease specialist Dr. Nicole Bouvier for Our Town

Syphilis in the City
 by infectious disease specialist Dr. Michelle Cespedes for Our Town

Take the Time to Check for Ticks
 by infectious disease specialist Dr. Christine Stavropoulos for Our Town

Sleep and the City 
 by sleep medicine specialist Dr. Neomi Shah for Our Town

Spring and Allergy Season Have Sprung
 by immunologist Dr. Shradha Agarwal for Our Town

Is it a cold or do I have allergies in the winter?
 by immunologist Dr. Shradha Agarwal for Our Town

Thyroid Cancer: It’s Not Simply a Pain in the Neck by endocrinologist Dr. Deena Adimoolam for Our Town

Early Intervention May Prevent Irreversible Damage in Inflammatory Bowel Disease
 by gastroenterologist Dr. Ryan Ungaro for Inside Mount Sinai
Why the Benefits of Hepatitis C Drug Therapies Outweigh the Risks
 by liver specialist, Dr. Douglas Dieterich for Inside Mount Sinai

Researchers Identify Genes That Predict Damage in Donated Kidneys
, Dr. Barbara Murphy for in Inside Mount Sinai 

How Might Physical Exercise Stimulate Bone Synthesis? by endocrinologist Dr. Mone Zaidi for Inside Mount Sinai

Delay in Diagnosing Psoriatic Arthritis Can Have Dire Consequences
 by rheumatologist Dr. Yousaf Ali for Inside Mount Sinai

Remote Monitoring Improves Readmission Rates for Heart Failure Patients, cardiologist Dr. Sean Pinney for Inside Mount Sinai

A New Focus of Study for Liver Disease Specialists, liver specialist Dr. Scott Friedman for Inside Mount Sinai

Rare Tumor May Provide Road Map to Diabetes Therapies, endocrinologist Dr. Andrew Stewart for Inside Mount Sinai

Blocking a Hormone Builds Bone and Burns Fat At Menopause, a Promising Study Finds, endocrinologist Dr. Andrew Stewart for Inside Mount Sinai 

Leader in Polycystic Ovary Syndrome Research is Chief of Endocrinology, Diabetes and Bone Disease, endocrinologist Dr. Andrea Dunaif for Inside Mount Sinai

Patient's Art Brightens Cancer Treatment Center, cancer specialist Dr. Sundar Jagannath for Inside Mount Sinai

Chief of Mount Sinai Heart Leads Panel on Global Health, cardiologist Dr. Valetin Fuster for Inside Mount Sinai









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