Sites in the Brain Where RNA Is Edited Could Help to Better Understand Neurodevelopment and Disease
November 1, 2022 - Mount Sinai researchers have catalogued thousands of sites in the brain where RNA is modified throughout the human lifespan in a process known as adenosine-to-inosine (A-to-I) editing, offering important new avenues for understanding the cellular and molecular mechanisms of brain development and how they factor into both health and disease.
Targeting One Type of Immune Cell With Another Slows Cancer Growth in Preclinical Studies
October 25, 2022 - A new approach to cancer immunotherapy that uses one type of immune cell to kill another—rather than directly attacking the cancer—provokes a robust anti-tumor immune response that shrinks ovarian, lung, and pancreatic tumors in preclinical disease models, according to researchers at the Icahn School of Medicine at Mount Sinai in New York.
Researchers Identify Flu-Fighting Pathways and Genes Essential for Influenza A Immune Defense
October 5, 2022 - Researchers have identified the gene TDRD7 as a key regulator against influenza A virus (IAV), which causes respiratory tract infections in 5 to 20 percent of the human population. These findings could facilitate the development of novel therapeutic interventions against influenza virus infection.
Researchers Identify a Potential Path Against Inherited Neurological Disease
September 8, 2022 - Scientists at the Icahn School of Medicine at Mount Sinai in New York, the National Center for Advancing Translational Sciences (NCATS), and elsewhere have reversed the effects of several life-threatening inherited neurodegenerative diseases called lysosomal storage disorders (LSDs) in patient cells and mice.
Mount Sinai Launches Large-Scale Genetic Sequencing Project with the Regeneron Genetics Center
August 12, 2022 - Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai have launched a new human genome sequencing research project called the Mount Sinai Million Health Discoveries Program with the Regeneron Genetics Center (RGC), part of the industry-leading, New York-based biotechnology company Regeneron.
Mount Sinai Awarded Three-Year Grant to Explore Therapeutic Approaches to KRAS Mutant Lung Tumors
August 9, 2022 - Mount Sinai is leading a team of lung cancer researchers that has been awarded a three-year, $500,000 grant from Stand Up To Cancer® (SU2C) to explore therapeutic approaches to lung tumors with mutations in the KRAS gene, an undertaking that could have a significant impact for a large population of cancer patients who currently lack effective treatment options.
Researchers Gain Insights Into the Genetic and Molecular Machinery that Predisposes Individuals to Alzheimer’s Disease
August 5, 2022 - Mount Sinai researchers have achieved an unprecedented understanding of the genetic and molecular machinery in human microglia—immune cells that reside in the brain—that could provide valuable insights into how they contribute to the development and progression of Alzheimer’s disease (AD).
Mount Sinai Designated as National Cancer Institute Proteogenomics Data Analysis Center
July 14, 2022 - The Office of Cancer Clinical Proteomics Research at the National Cancer Institute (NCI) has awarded $4.2 million over five years to Mount Sinai researchers establishing a Proteogenomic Data Analysis Center (PGDAC) to advance cancer research and treatments. Proteogenomics, which studies the roles of proteins and genes within a cell or organism, is a crucial area of exploration to further our understanding of cancer.
Mount Sinai Microbiome Lab Joins NIH’s Accelerating Medicines Partnership
May 19, 2022 - In this newly funded study, Dr. Jose Clemente and team will try to reconstruct and analyze how the microbiome may work in several autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus, psoriasis, psoriatic arthritis, and Sjögren’s disease.
Scientific Consortium Established by National Institutes of Health Provides Real-Time Risk Assessment of SARS-CoV-2 Variants on Immune Protection
March 31, 2022 - Program employs a coordinated approach and serves as a template for response against rapidly evolving pandemic pathogens
Novel CRISPR Imaging Technology Reveals Genes Controlling Tumor Immunity
March 15, 2022 - Next-generation spatial genomics technology paves the way for accelerating the discovery of new cancer drug targets
Are Scientists Being Fooled by Bacteria?
February 3, 2022 - Previous studies of a genetic on/off switch may have been confounded by contamination, but Mount Sinai scientists have created a new tool for accurately determining whether it plays a role in human disease.
Most “Pathogenic” Genetic Variants Have a Low Risk of Causing Disease
January 25, 2022 - Results of large biobank study by Mount Sinai researchers may help doctors better assess true disease risk.
Could Gene Networks Resembling Air Traffic Explain Arteriosclerosis?
January 12, 2022 - Mount Sinai-led study suggests that nearly 60 percent of the risk associated with coronary artery disease may be explained by the activity of multi-organ, gene networks orchestrated by fat processing hormones.
Can a Human Microglial Atlas Guide Brain Disorder Research?
January 6, 2022 - Mount Sinai-led study supports links between the brain’s immune cells and some cases of Alzheimer’s or Parkinson’s disease
Mount Sinai Alzheimer’s Researcher Wins Rainwater Prize for Outstanding Innovation in Neurodegenerative Research
December 14, 2021 - The Rainwater Charitable Foundation has named Alison M. Goate, DPhil, the Jean C. and James W. Crystal Professor and Chair of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai, as this year’s winner of the Rainwater Prize for Outstanding Innovation in Neurodegenerative Research. The prize recognizes Dr. Goate’s “significant contribution to our understanding of tau-related diseases,” such as Alzheimer’s disease and frontotemporal dementia.
Scientists Show How Bone-Bordering Cells May Help Shape a Skull
December 9, 2021 - Mount Sinai study of mice searched for the cells and genes that may orchestrate how skull bones are joined together
National Organization for Rare Disorders Designates The Mount Sinai Hospital as a Center of Excellence
November 4, 2021 - The National Organization for Rare Disorders (NORD) has designated the Division of Medical Genetics and Genomics at The Mount Sinai Hospital as a Rare Disease Center of Excellence. With this designation, Mount Sinai will join a highly selective nationwide network of 31 medical centers that specialize in rare disease diagnosis, treatment, and research
Childhood Asthma Study Uncovers Risky Air Pollutant Mixtures
October 6, 2021 - Mount Sinai researchers use a novel machine learning algorithm to discover that early exposure to a variety of toxic air pollutants can lead to poor asthma outcomes
Schizophrenia Study Suggests Advanced Genetic Scorecard Cannot Predict a Patient’s Fate
September 7, 2021 - Mount Sinai study showed that polygenic risk scores were no better at predicting whether a patient’s symptoms worsened than written reports