Scientific Consortium Established by National Institutes of Health Provides Real-Time Risk Assessment of SARS-CoV-2 Variants on Immune Protection
March 31, 2022 - Program employs a coordinated approach and serves as a template for response against rapidly evolving pandemic pathogens
Novel CRISPR Imaging Technology Reveals Genes Controlling Tumor Immunity
March 15, 2022 - Next-generation spatial genomics technology paves the way for accelerating the discovery of new cancer drug targets
Are Scientists Being Fooled by Bacteria?
February 3, 2022 - Previous studies of a genetic on/off switch may have been confounded by contamination, but Mount Sinai scientists have created a new tool for accurately determining whether it plays a role in human disease.
Most “Pathogenic” Genetic Variants Have a Low Risk of Causing Disease
January 25, 2022 - Results of large biobank study by Mount Sinai researchers may help doctors better assess true disease risk.
Could Gene Networks Resembling Air Traffic Explain Arteriosclerosis?
January 12, 2022 - Mount Sinai-led study suggests that nearly 60 percent of the risk associated with coronary artery disease may be explained by the activity of multi-organ, gene networks orchestrated by fat processing hormones
Can a Human Microglial Atlas Guide Brain Disorder Research?
January 6, 2022 - Mount Sinai-led study supports links between the brain’s immune cells and some cases of Alzheimer’s or Parkinson’s disease
Mount Sinai Alzheimer’s Researcher Wins Rainwater Prize for Outstanding Innovation in Neurodegenerative Research
December 14, 2021 - The Rainwater Charitable Foundation has named Alison M. Goate, DPhil, the Jean C. and James W. Crystal Professor and Chair of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai, as this year’s winner of the Rainwater Prize for Outstanding Innovation in Neurodegenerative Research. The prize recognizes Dr. Goate’s “significant contribution to our understanding of tau-related diseases,” such as Alzheimer’s disease and frontotemporal dementia.
Scientists Show How Bone-Bordering Cells May Help Shape a Skull
December 9, 2021 - Mount Sinai study of mice searched for the cells and genes that may orchestrate how skull bones are joined together
National Organization for Rare Disorders Designates The Mount Sinai Hospital as a Center of Excellence
November 4, 2021 - The National Organization for Rare Disorders (NORD) has designated the Division of Medical Genetics and Genomics at The Mount Sinai Hospital as a Rare Disease Center of Excellence. With this designation, Mount Sinai will join a highly selective nationwide network of 31 medical centers that specialize in rare disease diagnosis, treatment, and research
Childhood Asthma Study Uncovers Risky Air Pollutant Mixtures
October 6, 2021 - Mount Sinai researchers use a novel machine learning algorithm to discover that early exposure to a variety of toxic air pollutants can lead to poor asthma outcomes
Schizophrenia Study Suggests Advanced Genetic Scorecard Cannot Predict a Patient’s Fate
September 7, 2021 - Mount Sinai study showed that polygenic risk scores were no better at predicting whether a patient’s symptoms worsened than written reports
Scientists Create a Labor-Saving Automated Method for Studying Electronic Health Records
September 2, 2021 - Mount Sinai study suggests new method is as effective as manually-based “gold-standard” at classifying a diagnosis
Mount Sinai Researchers Find Important Clue to Rare Inflammatory Disease in Children Following COVID-19 Infection
August 12, 2021 - Mount Sinai researchers have found an important clue to a rare but serious aftereffect of COVID-19 in children, known as multisystem inflammatory syndrome in children or MIS-C.
Genetic Ancestry Versus Race Can Provide Specific, Targeted Insights to Predict and Treat Many Diseases
April 14, 2021 - Complex patterns of genetic ancestry uncovered from genomic data in health care systems can provide valuable insights into both genetic and environmental factors underlying many common and rare diseases
Mount Sinai Study Reveals Genetic and Cellular Mechanisms of Crohn’s Disease
March 31, 2021 - New study identifies a novel approach for tailored treatment that could be more effective for patients with the chronic disease
Mount Sinai Researchers Identify and Characterize Three Molecular Subtypes of Alzheimer’s Disease
January 6, 2021 - Critical Step Toward Developing Precision Medicine Treatments
Multi-Population Risk Scores Could Improve Risk Prediction for Inflammatory Bowel Diseases, Study Finds
December 24, 2020 - New study illustrates how studying diverse populations can help predict patient outcomes and reduce health disparities
First large-scale, multicenter proteogenomic analysis offers new insights into pediatric brain tumor biology
November 25, 2020 - Data reported can guide new therapeutic avenues for pediatric patients
Potential New Therapies for Alzheimer’s Disease are Revealed through Network Modeling of Its Complex Molecular Interactions
November 24, 2020 - Researchers from Mount Sinai and the National Center for Geriatrics and Gerontology in Japan have identified new molecular mechanisms driving late-onset Alzheimer’s Disease (LOAD), as well as a promising therapeutic candidate for treatment
Alison M. Goate Named Chair of Genetics and Genomic Sciences at Icahn School of Medicine at Mount Sinai
November 19, 2020 - Noted Alzheimer’s researcher will assume new role on January 1, 2021
Mount Sinai Receives Microsoft AI for Health Grant to Support Center Dedicated to Data Science Discovery for COVID-19
June 8, 2020 - Grant Will Enable Development of AI Tools to Enhance Care and Evidence-based Medicine for Treating COVID-19 Patients
Mount Sinai Study Finds First Cases of COVID-19 in New York City are Primarily from European and US Sources
June 2, 2020 - First definitive molecular epidemiology study of SARS-CoV-2 in New York City to describe the route by which the virus arrived
Mount Sinai Researchers: Why COVID-19 May Be Less Common in Children Than Adults
May 5, 2020 - Findings Published in JAMA Could Lead to Potential Biomarker of Susceptibility
Mount Sinai Launches App and First Campaign of The Resilience Project to Develop New Treatments and Preventive Care for Diseases
April 13, 2020 - Lyme Campaign Seeks Participants Who Are ‘Resilient’ to the Tick-borne Disease
Mount Sinai Launches COVID-19 App to Track Spread of Virus Across New York City
April 1, 2020 - A team of data scientists, physicians, and engineers across the Mount Sinai Health System has come together to launch STOP COVID NYC, a web-based app to capture the symptoms and spread of COVID-19 in New York City
Airway Microbiome and Host Interact Differently in Children with Severe Asthma
March 12, 2020 - The Mount Sinai study showed that airway microbes interact with inflammatory genes differently in healthy versus asthmatic children.
Researchers Identify Opportunities to Advance Genomic Medicine
January 27, 2020 - New Study Highlights Milestones in the History of Genetic Discoveries; Equitable and Fair Access Required to Address Disparities
Researchers Show Different Mutations in a Single Gene Can Wreak Many Types of Havoc in Brain Cells
December 19, 2019 - NRXN1 undergoes extensive alternative splicing, and non-recurrent heterozygous deletions in NRXN1 are strongly associated with neuropsychiatric disorders. The study published in Nature Genetics reported links to patient-specific, heterozygous intragenic deletions in NRXN1 to isoform dysregulation and impaired neuronal maturation and activity in a human and disease-relevant context.
December 12, 2019 - Researchers at the Icahn School of Medicine at Mount Sinai have identified novel genes associated with the severity of peanut allergy, as well as ways in which these genes interact with other genes during allergic reactions. The findings, published in the Journal of Allergy and Clinical Immunology, could lead to better treatments for peanut allergy.
Genetic Breakthrough Identifies Heart Failure Risk in African and Latino Americans
December 10, 2019 - A genetic variation believed to increase risk for heart failure in people of African or Latino ancestry has been identified in a new study by researchers from the Icahn School of Medicine at Mount Sinai and Perelman School of Medicine at the University of Pennsylvania. The study found that the transthyretin or TTR V122I genetic variant was significantly associated with heart failure and that heredity transthyretin amyloid cardiomyopathy (hATTR-CM) caused by this variant was confirmed at appreciable frequency in individuals of African or Latino ancestry. The results were published in JAMA.
New Discovery in C. difficile Biology Could Lead to Treatments for Dangerous Bacterial Infections
November 25, 2019 - A process called sporulation that helps the dangerous bacterium Clostridium difficile (C. difficile) to survive inhospitable conditions and spread is regulated by epigenetics, factors that affect gene expression beyond the DNA genetic code, researchers at the Icahn School of Medicine at Mount Sinai report. This is the first discovery that epigenetics regulate sporulation in any bacteria. Their research, published November 25th in Nature Microbiology, opens a new window to developing treatments for this devestating infection.
Mount Sinai Researchers Uncover New Molecular Drivers of Parkinson’s Disease
November 20, 2019 - Scientists at the Icahn School of Medicine at Mount Sinai have uncovered new molecular drivers of Parkinson’s disease using a sophisticated statistical technique called multiscale gene network analysis (MGNA). The team was also able to determine how these molecular drivers impact the functions of genes involved in the disease. The results were published in Nature Communications.
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