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Schizophrenia Study Suggests Advanced Genetic Scorecard Cannot Predict a Patient’s Fate
September 7, 2021 - Mount Sinai study showed that polygenic risk scores were no better at predicting whether a patient’s symptoms worsened than written reports

Scientists Create a Labor-Saving Automated Method for Studying Electronic Health Records
September 2, 2021 - Mount Sinai study suggests new method is as effective as manually-based “gold-standard” at classifying a diagnosis

Mount Sinai Researchers Find Important Clue to Rare Inflammatory Disease in Children Following COVID-19 Infection
August 12, 2021 - Mount Sinai researchers have found an important clue to a rare but serious aftereffect of COVID-19 in children, known as multisystem inflammatory syndrome in children or MIS-C.

Genetic Ancestry Versus Race Can Provide Specific, Targeted Insights to Predict and Treat Many Diseases
April 14, 2021 - Complex patterns of genetic ancestry uncovered from genomic data in health care systems can provide valuable insights into both genetic and environmental factors underlying many common and rare diseases

Mount Sinai Study Reveals Genetic and Cellular Mechanisms of Crohn’s Disease
March 31, 2021 - New study identifies a novel approach for tailored treatment that could be more effective for patients with the chronic disease

Mount Sinai Researchers Identify and Characterize Three Molecular Subtypes of Alzheimer’s Disease
January 6, 2021 - Critical Step Toward Developing Precision Medicine Treatments

Multi-Population Risk Scores Could Improve Risk Prediction for Inflammatory Bowel Diseases, Study Finds
December 24, 2020 - New study illustrates how studying diverse populations can help predict patient outcomes and reduce health disparities

First large-scale, multicenter proteogenomic analysis offers new insights into pediatric brain tumor biology
November 25, 2020 - Data reported can guide new therapeutic avenues for pediatric patients

Potential New Therapies for Alzheimer’s Disease are Revealed through Network Modeling of Its Complex Molecular Interactions
November 24, 2020 - Researchers from Mount Sinai and the National Center for Geriatrics and Gerontology in Japan have identified new molecular mechanisms driving late-onset Alzheimer’s Disease (LOAD), as well as a promising therapeutic candidate for treatment

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News Medical Life Sciences: Researchers at the Icahn School of Medicine at Mount Sinai have identified three major molecular subtypes of Alzheimer's disease (AD) using data from RNA sequencing. The study advances our understanding of the mechanisms of AD and could pave the way for developing novel, personalized therapeutics. (1.7.21) Full story

News Medical Life Sciences: The Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai and Rumi Scientific announced today that they will team up to initiate a drug discovery pipeline for rare genetic disorders that carry a high risk of autism. The Seaver Autism Center is led by Joseph Buxbaum, PhD, Professor of Psychiatry, Neuroscience, and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai. (1.6.21) Full story

STAT: A consortium of researchers led by Mount Sinai's Pei Wang, PhD, delved into the molecular details of 218 pediatric brain tumors, analyzing the genes, proteins, and RNA transcription that allow these cancers to proliferate. This analysis, which identified a number of unique proteins created by different types of brain tumors, allowed the researchers to draw connections between the presence of certain proteins and a patient’s prognosis. (11.25.20) Full story

HIT Consultant: Mount Sinai researchers have developed machine learning models that predict the likelihood of critical events and mortality in COVID-19 patients within clinically relevant time windows. (11.11.20) Full story 

New York Times: New research including scientists from the Department of Genetics and Genomic Sciences, indicates that the coronavirus began to circulate in the New York area by mid-February, weeks before the first confirmed case, and that travelers brought in the virus mainly from Europe, not Asia. (4.8.20) Full story.

More In the News

Schizophrenia Study Suggests Advanced Genetic Scorecard Cannot Predict a Patient’s Fate
September 7, 2021 - Mount Sinai study showed that polygenic risk scores were no better at predicting whether a patient’s symptoms worsened than written reports

Scientists Create a Labor-Saving Automated Method for Studying Electronic Health Records
September 2, 2021 - Mount Sinai study suggests new method is as effective as manually-based “gold-standard” at classifying a diagnosis

Mount Sinai Researchers Find Important Clue to Rare Inflammatory Disease in Children Following COVID-19 Infection
August 12, 2021 - Mount Sinai researchers have found an important clue to a rare but serious aftereffect of COVID-19 in children, known as multisystem inflammatory syndrome in children or MIS-C.

Genetic Ancestry Versus Race Can Provide Specific, Targeted Insights to Predict and Treat Many Diseases
April 14, 2021 - Complex patterns of genetic ancestry uncovered from genomic data in health care systems can provide valuable insights into both genetic and environmental factors underlying many common and rare diseases

Mount Sinai Study Reveals Genetic and Cellular Mechanisms of Crohn’s Disease
March 31, 2021 - New study identifies a novel approach for tailored treatment that could be more effective for patients with the chronic disease

Mount Sinai Researchers Identify and Characterize Three Molecular Subtypes of Alzheimer’s Disease
January 6, 2021 - Critical Step Toward Developing Precision Medicine Treatments

Multi-Population Risk Scores Could Improve Risk Prediction for Inflammatory Bowel Diseases, Study Finds
December 24, 2020 - New study illustrates how studying diverse populations can help predict patient outcomes and reduce health disparities

First large-scale, multicenter proteogenomic analysis offers new insights into pediatric brain tumor biology
November 25, 2020 - Data reported can guide new therapeutic avenues for pediatric patients

Potential New Therapies for Alzheimer’s Disease are Revealed through Network Modeling of Its Complex Molecular Interactions
November 24, 2020 - Researchers from Mount Sinai and the National Center for Geriatrics and Gerontology in Japan have identified new molecular mechanisms driving late-onset Alzheimer’s Disease (LOAD), as well as a promising therapeutic candidate for treatment

Alison M. Goate Named Chair of Genetics and Genomic Sciences at Icahn School of Medicine at Mount Sinai
November 19, 2020 - Noted Alzheimer’s researcher will assume new role on January 1, 2021

Mount Sinai Receives Microsoft AI for Health Grant to Support Center Dedicated to Data Science Discovery for COVID-19
June 8, 2020 - Grant Will Enable Development of AI Tools to Enhance Care and Evidence-based Medicine for Treating COVID-19 Patients

Mount Sinai Study Finds First Cases of COVID-19 in New York City are Primarily from European and US Sources
June 2, 2020 - First definitive molecular epidemiology study of SARS-CoV-2 in New York City to describe the route by which the virus arrived

Mount Sinai Researchers: Why COVID-19 May Be Less Common in Children Than Adults
May 5, 2020 - Findings Published in JAMA Could Lead to Potential Biomarker of Susceptibility

Mount Sinai Launches App and First Campaign of The Resilience Project to Develop New Treatments and Preventive Care for Diseases
April 13, 2020 - Lyme Campaign Seeks Participants Who Are ‘Resilient’ to the Tick-borne Disease

Mount Sinai Launches COVID-19 App to Track Spread of Virus Across New York City
April 1, 2020 - A team of data scientists, physicians, and engineers across the Mount Sinai Health System has come together to launch STOP COVID NYC, a web-based app to capture the symptoms and spread of COVID-19 in New York City

Airway Microbiome and Host Interact Differently in Children with Severe Asthma
March 12, 2020 - The Mount Sinai study showed that airway microbes interact with inflammatory genes differently in healthy versus asthmatic children.

Researchers Identify Opportunities to Advance Genomic Medicine
January 27, 2020 - New Study Highlights Milestones in the History of Genetic Discoveries; Equitable and Fair Access Required to Address Disparities

Researchers Show Different Mutations in a Single Gene Can Wreak Many Types of Havoc in Brain Cells

December 19, 2019 - NRXN1 undergoes extensive alternative splicing, and non-recurrent heterozygous deletions in NRXN1 are strongly associated with neuropsychiatric disorders. The study published in Nature Genetics reported links to patient-specific, heterozygous intragenic deletions in NRXN1 to isoform dysregulation and impaired neuronal maturation and activity in a human and disease-relevant context.

December 12, 2019 - Researchers at the Icahn School of Medicine at Mount Sinai have identified novel genes associated with the severity of peanut allergy, as well as ways in which these genes interact with other genes during allergic reactions. The findings, published in the Journal of Allergy and Clinical Immunology, could lead to better treatments for peanut allergy. 

Genetic Breakthrough Identifies Heart Failure Risk in African and Latino Americans

December 10, 2019 - A genetic variation believed to increase risk for heart failure in people of African or Latino ancestry has been identified in a new study by researchers from the Icahn School of Medicine at Mount Sinai and Perelman School of Medicine at the University of Pennsylvania. The study found that the transthyretin or TTR V122I genetic variant was significantly associated with heart failure and that heredity transthyretin amyloid cardiomyopathy (hATTR-CM) caused by this variant was confirmed at appreciable frequency in individuals of African or Latino ancestry. The results were published in JAMA.

New Discovery in C. difficile Biology Could Lead to Treatments for Dangerous Bacterial Infections

November 25, 2019 - A process called sporulation that helps the dangerous bacterium Clostridium difficile (C. difficile) to survive inhospitable conditions and spread is regulated by epigenetics, factors that affect gene expression beyond the DNA genetic code, researchers at the Icahn School of Medicine at Mount Sinai report. This is the first discovery that epigenetics regulate sporulation in any bacteria. Their research, published November 25th in Nature Microbiology, opens a new window to developing treatments for this devestating infection.

Mount Sinai Researchers Uncover New Molecular Drivers of Parkinson’s Disease

November 20, 2019 - Scientists at the Icahn School of Medicine at Mount Sinai have uncovered new molecular drivers of Parkinson’s disease using a sophisticated statistical technique called multiscale gene network analysis (MGNA). The team was also able to determine how these molecular drivers impact the functions of genes involved in the disease. The results were published in Nature Communications.

 

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