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Sites in the Brain Where RNA Is Edited Could Help to Better Understand Neurodevelopment and Disease
November 1, 2022 - Mount Sinai researchers have catalogued thousands of sites in the brain where RNA is modified throughout the human lifespan in a process known as adenosine-to-inosine (A-to-I) editing, offering important new avenues for understanding the cellular and molecular mechanisms of brain development and how they factor into both health and disease.

Targeting One Type of Immune Cell With Another Slows Cancer Growth in Preclinical Studies

October 25, 2022 - A new approach to cancer immunotherapy that uses one type of immune cell to kill another—rather than directly attacking the cancer—provokes a robust anti-tumor immune response that shrinks ovarian, lung, and pancreatic tumors in preclinical disease models, according to researchers at the Icahn School of Medicine at Mount Sinai in New York. 

Researchers Identify Flu-Fighting Pathways and Genes Essential for Influenza A Immune Defense
October 5, 2022 - Researchers have identified the gene TDRD7 as a key regulator against influenza A virus (IAV), which causes respiratory tract infections in 5 to 20 percent of the human population. These findings could facilitate the development of novel therapeutic interventions against influenza virus infection.

Researchers Identify a Potential Path Against Inherited Neurological Disease
September 8, 2022 - Scientists at the Icahn School of Medicine at Mount Sinai in New York, the National Center for Advancing Translational Sciences (NCATS), and elsewhere have reversed the effects of several life-threatening inherited neurodegenerative diseases called lysosomal storage disorders (LSDs) in patient cells and mice.

Mount Sinai Launches Large-Scale Genetic Sequencing Project with the Regeneron Genetics Center
August 12, 2022 - Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai have launched a new human genome sequencing research project called the Mount Sinai Million Health Discoveries Program with the Regeneron Genetics Center (RGC), part of the industry-leading, New York-based biotechnology company Regeneron.

Mount Sinai Awarded Three-Year Grant to Explore Therapeutic Approaches to KRAS Mutant Lung Tumors
August 9, 2022 - Mount Sinai is leading a team of lung cancer researchers that has been awarded a three-year, $500,000 grant from Stand Up To Cancer® (SU2C) to explore therapeutic approaches to lung tumors with mutations in the KRAS gene, an undertaking that could have a significant impact for a large population of cancer patients who currently lack effective treatment options.

Researchers Gain Insights Into the Genetic and Molecular Machinery that Predisposes Individuals to Alzheimer’s Disease
August 5, 2022 - Mount Sinai researchers have achieved an unprecedented understanding of the genetic and molecular machinery in human microglia—immune cells that reside in the brain—that could provide valuable insights into how they contribute to the development and progression of Alzheimer’s disease (AD).

Mount Sinai Designated as National Cancer Institute Proteogenomics Data Analysis Center
July 14, 2022 - The Office of Cancer Clinical Proteomics Research at the National Cancer Institute (NCI) has awarded $4.2 million over five years to Mount Sinai researchers establishing a Proteogenomic Data Analysis Center (PGDAC) to advance cancer research and treatments. Proteogenomics, which studies the roles of proteins and genes within a cell or organism, is a crucial area of exploration to further our understanding of cancer.

Mount Sinai Microbiome Lab Joins NIH’s Accelerating Medicines Partnership
May 19, 2022 - In this newly funded study, Dr. Jose Clemente and team will try to reconstruct and analyze how the microbiome may work in several autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus, psoriasis, psoriatic arthritis, and Sjögren’s disease.

Scientific Consortium Established by National Institutes of Health Provides Real-Time Risk Assessment of SARS-CoV-2 Variants on Immune Protection
March 31, 2022 - Program employs a coordinated approach and serves as a template for response against rapidly evolving pandemic pathogens

Novel CRISPR Imaging Technology Reveals Genes Controlling Tumor Immunity
March 15, 2022 - Next-generation spatial genomics technology paves the way for accelerating the discovery of new cancer drug targets

Are Scientists Being Fooled by Bacteria?
February 3, 2022 - Previous studies of a genetic on/off switch may have been confounded by contamination, but Mount Sinai scientists have created a new tool for accurately determining whether it plays a role in human disease.

Most “Pathogenic” Genetic Variants Have a Low Risk of Causing Disease
January 25, 2022 - Results of large biobank study by Mount Sinai researchers may help doctors better assess true disease risk.

Could Gene Networks Resembling Air Traffic Explain Arteriosclerosis?
January 12, 2022 - Mount Sinai-led study suggests that nearly 60 percent of the risk associated with coronary artery disease may be explained by the activity of multi-organ, gene networks orchestrated by fat processing hormones.

Can a Human Microglial Atlas Guide Brain Disorder Research?
January 6, 2022 - Mount Sinai-led study supports links between the brain’s immune cells and some cases of Alzheimer’s or Parkinson’s disease

Mount Sinai Alzheimer’s Researcher Wins Rainwater Prize for Outstanding Innovation in Neurodegenerative Research
December 14, 2021 - The Rainwater Charitable Foundation has named Alison M. Goate, DPhil, the Jean C. and James W. Crystal Professor and Chair of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai, as this year’s winner of the Rainwater Prize for Outstanding Innovation in Neurodegenerative Research. The prize recognizes Dr. Goate’s “significant contribution to our understanding of tau-related diseases,” such as Alzheimer’s disease and frontotemporal dementia.

Scientists Show How Bone-Bordering Cells May Help Shape a Skull
December 9, 2021 - Mount Sinai study of mice searched for the cells and genes that may orchestrate how skull bones are joined together

National Organization for Rare Disorders Designates The Mount Sinai Hospital as a Center of Excellence
November 4, 2021 - The National Organization for Rare Disorders (NORD) has designated the Division of Medical Genetics and Genomics at The Mount Sinai Hospital as a Rare Disease Center of Excellence. With this designation, Mount Sinai will join a highly selective nationwide network of 31 medical centers that specialize in rare disease diagnosis, treatment, and research

Childhood Asthma Study Uncovers Risky Air Pollutant Mixtures
October 6, 2021 - Mount Sinai researchers use a novel machine learning algorithm to discover that early exposure to a variety of toxic air pollutants can lead to poor asthma outcomes

Schizophrenia Study Suggests Advanced Genetic Scorecard Cannot Predict a Patient’s Fate
September 7, 2021 - Mount Sinai study showed that polygenic risk scores were no better at predicting whether a patient’s symptoms worsened than written reports

More Press Releases

Everyday Health: Tehilla Brander, MS, CGC, discusses implications of BRCA1 and BRCA2 mutations on impact prostate cancer risk (10.21.22) Full Story

Innovation & Tech Today: Brian Brown, PhD, and Alessia Baccarini, PhD discuss how advances in technologies are leading way to a new type of evolution for humanity; a review of San Diego Comic Con Panel discussion "Accelerating Evolution: How Technology is Making Humans Super" (10.13.22) Full Story

Genome Web: Panos Roussos, PhD, discusses study identifying risk variants for neuropsychiatric disease by tracking enhancer expression. (9.27.22) Full Story

Gastroenterology & Endoscopy News: Inga Peter, PhD, discusses new findings suggesting a link between Parkinson's disease and IBD. (9.6.22) Full Story

Genome Web: Alex Charney, PhD, discusses Mount Sinai partnership with Regeneron in Mount Sinai Million Health Discoveries Program. (8.24.22) Full Story

The Hill: Joseph Buxbaum, PhD, discusses largest study yet identifying over 200 genes strongly linked to autism. (8.17.22) Full Story

Genome Web: Alison Goate, DPhil, comments on a new method to identify novel Alzheimer's gene candidates. (8.8.22) Full Story

The Scientist: Jeremiah Faith, PhD, discusses study findings with implications for new, targeted immune-based therapies. (7.8.22) Full Story

The Scientist: Brian Brown, PhD, discusses the new CRISPR screening technology allowing recreation of tumor heterogeneity in vivo. (6.27.22) Full Story

Genome Web: Review of studies indicating shared pathways providing insights into the underlying bioloy of neuropsychiatric conditions with comment from one of the study authors, Paul O'Reilly, PhD. (4.6.22). Full Story 

Genetic Engineering News: Brian Brown, PhD, discusses spatial CRISPR genomics of tumor microenvironments (3.16.22) Full Story

Genome Web: Towfique Raj, PhD, discusses study uncovering thousands of structural variants affecting gene regulation in the brain and brain disorder risk (3.15.22) Full Story

Genome Web: Laura Huckins, PhD, discusses a study indicating that genetics of cardiometabolic traits are informed by predicted gene expression across ancestries and the "ethical imperative to improve diversity in functional genomics and transcriptomics studies" (3.8.22) Full Story

Select Science: Ben Hopkins, PhD, discusses how combining transcriptomics with organoid-based drug screening could bring effective therapies to cancer patients sooner. (3.7.22) Full Story

Genetic Engineering News: Ron Do, PhD and Iain Forrest, PhD, discuss study on association between pathogenic varients and disease. (1.26.22) Full Story

Genome Web: Ron Do, PhD, discusses a study using biobank and EHR data to determine how often individuals with pathogenic disease varients were diagnosed with those diseases. (1.25.22) Full Story

Genome Web: Panos Roussos, MD, discusses identification of candidate causal variants for neuropsychiatric and neurodevelopmental conditions. (1.21.22) Full Story

Medpage Today: Manisha Balwani, MD, discusses clinical challenges in managing erythropoietic protoporphyria. (1.11.22) Full Story

Myeloma Research News: Alessandro Lagana, PhD, discusses his study regarding a model developed that may better classify multiple myeloma using genetic sequence data from hundreds of patients. (1.17.22) Full Story

The Wall Street Journal: A Grieving Family Wonders: What if They Had Known the Medical History of Sperm Donor 1558? (1.2.22) Full Story

Medscape: Niamh Mullins, PhD, discusses her research on a risk locus on chromosome 7 containing DNA variations that increase the risk that an individual will attempt suicide, even in the absence of a psychiatric disorder. (12.29.21) Full Story

MedPage Today: Manisha Balwani, MD, MS, discusses her research on treating acute hepatic porphyria. (12.29.21) Full Story

News Medical Life Sciences: Researchers at the Icahn School of Medicine at Mount Sinai have identified three major molecular subtypes of Alzheimer's disease (AD) using data from RNA sequencing. The study advances our understanding of the mechanisms of AD and could pave the way for developing novel, personalized therapeutics. (1.7.21) Full story

News Medical Life Sciences: The Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai and Rumi Scientific announced today that they will team up to initiate a drug discovery pipeline for rare genetic disorders that carry a high risk of autism. The Seaver Autism Center is led by Joseph Buxbaum, PhD, Professor of Psychiatry, Neuroscience, and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai. (1.6.21) Full story

STAT: A consortium of researchers led by Mount Sinai's Pei Wang, PhD, delved into the molecular details of 218 pediatric brain tumors, analyzing the genes, proteins, and RNA transcription that allow these cancers to proliferate. This analysis, which identified a number of unique proteins created by different types of brain tumors, allowed the researchers to draw connections between the presence of certain proteins and a patient’s prognosis. (11.25.20) Full story

HIT Consultant: Mount Sinai researchers have developed machine learning models that predict the likelihood of critical events and mortality in COVID-19 patients within clinically relevant time windows. (11.11.20) Full story 

Healio: Gaurav Pandey, PhD, and Supinda Bunyavanich, PhD, discuss new algorithm providing holistic view of how air pollution contributes to asthma in children. (11.1.21) Full Story

New York Times: New research including scientists from the Department of Genetics and Genomic Sciences, indicates that the coronavirus began to circulate in the New York area by mid-February, weeks before the first confirmed case, and that travelers brought in the virus mainly from Europe, not Asia. (4.8.20) Full story.

More In the News

Sites in the Brain Where RNA Is Edited Could Help to Better Understand Neurodevelopment and Disease
November 1, 2022 - Mount Sinai researchers have catalogued thousands of sites in the brain where RNA is modified throughout the human lifespan in a process known as adenosine-to-inosine (A-to-I) editing, offering important new avenues for understanding the cellular and molecular mechanisms of brain development and how they factor into both health and disease.

Targeting One Type of Immune Cell With Another Slows Cancer Growth in Preclinical Studies
October 25, 2022 - A new approach to cancer immunotherapy that uses one type of immune cell to kill another—rather than directly attacking the cancer—provokes a robust anti-tumor immune response that shrinks ovarian, lung, and pancreatic tumors in preclinical disease models, according to researchers at the Icahn School of Medicine at Mount Sinai in New York. 

Researchers Identify Flu-Fighting Pathways and Genes Essential for Influenza A Immune Defense
October 5, 2022 - Researchers have identified the gene TDRD7 as a key regulator against influenza A virus (IAV), which causes respiratory tract infections in 5 to 20 percent of the human population. These findings could facilitate the development of novel therapeutic interventions against influenza virus infection.

Researchers Identify a Potential Path Against Inherited Neurological Disease
September 8, 2022 - Scientists at the Icahn School of Medicine at Mount Sinai in New York, the National Center for Advancing Translational Sciences (NCATS), and elsewhere have reversed the effects of several life-threatening inherited neurodegenerative diseases called lysosomal storage disorders (LSDs) in patient cells and mice.

Mount Sinai Launches Large-Scale Genetic Sequencing Project with the Regeneron Genetics Center
August 12, 2022 - Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai have launched a new human genome sequencing research project called the Mount Sinai Million Health Discoveries Program with the Regeneron Genetics Center (RGC), part of the industry-leading, New York-based biotechnology company Regeneron.

Mount Sinai Awarded Three-Year Grant to Explore Therapeutic Approaches to KRAS Mutant Lung Tumors
August 9, 2022 - Mount Sinai is leading a team of lung cancer researchers that has been awarded a three-year, $500,000 grant from Stand Up To Cancer® (SU2C) to explore therapeutic approaches to lung tumors with mutations in the KRAS gene, an undertaking that could have a significant impact for a large population of cancer patients who currently lack effective treatment options.

Researchers Gain Insights Into the Genetic and Molecular Machinery that Predisposes Individuals to Alzheimer’s Disease
August 5, 2022 - Mount Sinai researchers have achieved an unprecedented understanding of the genetic and molecular machinery in human microglia—immune cells that reside in the brain—that could provide valuable insights into how they contribute to the development and progression of Alzheimer’s disease (AD).

Mount Sinai Designated as National Cancer Institute Proteogenomics Data Analysis Center
July 14, 2022 - The Office of Cancer Clinical Proteomics Research at the National Cancer Institute (NCI) has awarded $4.2 million over five years to Mount Sinai researchers establishing a Proteogenomic Data Analysis Center (PGDAC) to advance cancer research and treatments. Proteogenomics, which studies the roles of proteins and genes within a cell or organism, is a crucial area of exploration to further our understanding of cancer.

Mount Sinai Microbiome Lab Joins NIH’s Accelerating Medicines Partnership
May 19, 2022 - In this newly funded study, Dr. Jose Clemente and team will try to reconstruct and analyze how the microbiome may work in several autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus, psoriasis, psoriatic arthritis, and Sjögren’s disease.

Scientific Consortium Established by National Institutes of Health Provides Real-Time Risk Assessment of SARS-CoV-2 Variants on Immune Protection
March 31, 2022 - Program employs a coordinated approach and serves as a template for response against rapidly evolving pandemic pathogens

Scientific Consortium Established by National Institutes of Health Provides Real-Time Risk Assessment of SARS-CoV-2 Variants on Immune Protection
March 31, 2022 - Program employs a coordinated approach and serves as a template for response against rapidly evolving pandemic pathogens

Novel CRISPR Imaging Technology Reveals Genes Controlling Tumor Immunity
March 15, 2022 - Next-generation spatial genomics technology paves the way for accelerating the discovery of new cancer drug targets

Are Scientists Being Fooled by Bacteria?
February 3, 2022 - Previous studies of a genetic on/off switch may have been confounded by contamination, but Mount Sinai scientists have created a new tool for accurately determining whether it plays a role in human disease.

Most “Pathogenic” Genetic Variants Have a Low Risk of Causing Disease
January 25, 2022 - Results of large biobank study by Mount Sinai researchers may help doctors better assess true disease risk.

Could Gene Networks Resembling Air Traffic Explain Arteriosclerosis?
January 12, 2022 - Mount Sinai-led study suggests that nearly 60 percent of the risk associated with coronary artery disease may be explained by the activity of multi-organ, gene networks orchestrated by fat processing hormones

Can a Human Microglial Atlas Guide Brain Disorder Research?
January 6, 2022 - Mount Sinai-led study supports links between the brain’s immune cells and some cases of Alzheimer’s or Parkinson’s disease

Mount Sinai Alzheimer’s Researcher Wins Rainwater Prize for Outstanding Innovation in Neurodegenerative Research
December 14, 2021 - The Rainwater Charitable Foundation has named Alison M. Goate, DPhil, the Jean C. and James W. Crystal Professor and Chair of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai, as this year’s winner of the Rainwater Prize for Outstanding Innovation in Neurodegenerative Research. The prize recognizes Dr. Goate’s “significant contribution to our understanding of tau-related diseases,” such as Alzheimer’s disease and frontotemporal dementia.

Scientists Show How Bone-Bordering Cells May Help Shape a Skull
December 9, 2021 - Mount Sinai study of mice searched for the cells and genes that may orchestrate how skull bones are joined together

National Organization for Rare Disorders Designates The Mount Sinai Hospital as a Center of Excellence
November 4, 2021 - The National Organization for Rare Disorders (NORD) has designated the Division of Medical Genetics and Genomics at The Mount Sinai Hospital as a Rare Disease Center of Excellence. With this designation, Mount Sinai will join a highly selective nationwide network of 31 medical centers that specialize in rare disease diagnosis, treatment, and research

Childhood Asthma Study Uncovers Risky Air Pollutant Mixtures
October 6, 2021 - Mount Sinai researchers use a novel machine learning algorithm to discover that early exposure to a variety of toxic air pollutants can lead to poor asthma outcomes

Schizophrenia Study Suggests Advanced Genetic Scorecard Cannot Predict a Patient’s Fate
September 7, 2021 - Mount Sinai study showed that polygenic risk scores were no better at predicting whether a patient’s symptoms worsened than written reports

Mount Sinai Researchers Find Important Clue to Rare Inflammatory Disease in Children Following COVID-19 Infection
August 12, 2021 - Mount Sinai researchers have found an important clue to a rare but serious aftereffect of COVID-19 in children, known as multisystem inflammatory syndrome in children or MIS-C.

Genetic Ancestry Versus Race Can Provide Specific, Targeted Insights to Predict and Treat Many Diseases
April 14, 2021 - Complex patterns of genetic ancestry uncovered from genomic data in health care systems can provide valuable insights into both genetic and environmental factors underlying many common and rare diseases

Mount Sinai Study Reveals Genetic and Cellular Mechanisms of Crohn’s Disease
March 31, 2021 - New study identifies a novel approach for tailored treatment that could be more effective for patients with the chronic disease

Mount Sinai Researchers Identify and Characterize Three Molecular Subtypes of Alzheimer’s Disease
January 6, 2021 - Critical Step Toward Developing Precision Medicine Treatments

Multi-Population Risk Scores Could Improve Risk Prediction for Inflammatory Bowel Diseases, Study Finds
December 24, 2020 - New study illustrates how studying diverse populations can help predict patient outcomes and reduce health disparities

First large-scale, multicenter proteogenomic analysis offers new insights into pediatric brain tumor biology
November 25, 2020 - Data reported can guide new therapeutic avenues for pediatric patients

Potential New Therapies for Alzheimer’s Disease are Revealed through Network Modeling of Its Complex Molecular Interactions
November 24, 2020 - Researchers from Mount Sinai and the National Center for Geriatrics and Gerontology in Japan have identified new molecular mechanisms driving late-onset Alzheimer’s Disease (LOAD), as well as a promising therapeutic candidate for treatment

Alison M. Goate Named Chair of Genetics and Genomic Sciences at Icahn School of Medicine at Mount Sinai
November 19, 2020 - Noted Alzheimer’s researcher will assume new role on January 1, 2021

Mount Sinai Receives Microsoft AI for Health Grant to Support Center Dedicated to Data Science Discovery for COVID-19
June 8, 2020 - Grant Will Enable Development of AI Tools to Enhance Care and Evidence-based Medicine for Treating COVID-19 Patients

Mount Sinai Study Finds First Cases of COVID-19 in New York City are Primarily from European and US Sources
June 2, 2020 - First definitive molecular epidemiology study of SARS-CoV-2 in New York City to describe the route by which the virus arrived

Mount Sinai Researchers: Why COVID-19 May Be Less Common in Children Than Adults
May 5, 2020 - Findings Published in JAMA Could Lead to Potential Biomarker of Susceptibility

Mount Sinai Launches App and First Campaign of The Resilience Project to Develop New Treatments and Preventive Care for Diseases
April 13, 2020 - Lyme Campaign Seeks Participants Who Are ‘Resilient’ to the Tick-borne Disease

Mount Sinai Launches COVID-19 App to Track Spread of Virus Across New York City
April 1, 2020 - A team of data scientists, physicians, and engineers across the Mount Sinai Health System has come together to launch STOP COVID NYC, a web-based app to capture the symptoms and spread of COVID-19 in New York City

Airway Microbiome and Host Interact Differently in Children with Severe Asthma
March 12, 2020 - The Mount Sinai study showed that airway microbes interact with inflammatory genes differently in healthy versus asthmatic children.

Researchers Identify Opportunities to Advance Genomic Medicine
January 27, 2020 - New Study Highlights Milestones in the History of Genetic Discoveries; Equitable and Fair Access Required to Address Disparities

Researchers Show Different Mutations in a Single Gene Can Wreak Many Types of Havoc in Brain Cells

December 19, 2019 - NRXN1 undergoes extensive alternative splicing, and non-recurrent heterozygous deletions in NRXN1 are strongly associated with neuropsychiatric disorders. The study published in Nature Genetics reported links to patient-specific, heterozygous intragenic deletions in NRXN1 to isoform dysregulation and impaired neuronal maturation and activity in a human and disease-relevant context.

December 12, 2019 - Researchers at the Icahn School of Medicine at Mount Sinai have identified novel genes associated with the severity of peanut allergy, as well as ways in which these genes interact with other genes during allergic reactions. The findings, published in the Journal of Allergy and Clinical Immunology, could lead to better treatments for peanut allergy. 

Genetic Breakthrough Identifies Heart Failure Risk in African and Latino Americans

December 10, 2019 - A genetic variation believed to increase risk for heart failure in people of African or Latino ancestry has been identified in a new study by researchers from the Icahn School of Medicine at Mount Sinai and Perelman School of Medicine at the University of Pennsylvania. The study found that the transthyretin or TTR V122I genetic variant was significantly associated with heart failure and that heredity transthyretin amyloid cardiomyopathy (hATTR-CM) caused by this variant was confirmed at appreciable frequency in individuals of African or Latino ancestry. The results were published in JAMA.

New Discovery in C. difficile Biology Could Lead to Treatments for Dangerous Bacterial Infections

November 25, 2019 - A process called sporulation that helps the dangerous bacterium Clostridium difficile (C. difficile) to survive inhospitable conditions and spread is regulated by epigenetics, factors that affect gene expression beyond the DNA genetic code, researchers at the Icahn School of Medicine at Mount Sinai report. This is the first discovery that epigenetics regulate sporulation in any bacteria. Their research, published November 25th in Nature Microbiology, opens a new window to developing treatments for this devestating infection.

Mount Sinai Researchers Uncover New Molecular Drivers of Parkinson’s Disease

November 20, 2019 - Scientists at the Icahn School of Medicine at Mount Sinai have uncovered new molecular drivers of Parkinson’s disease using a sophisticated statistical technique called multiscale gene network analysis (MGNA). The team was also able to determine how these molecular drivers impact the functions of genes involved in the disease. The results were published in Nature Communications.

 

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