The research advances produced by the Department of Genetics and Genomic Sciences are routinely featured in the news, research publications, and other media.
News Medical Life Sciences: Researchers at the Icahn School of Medicine at Mount Sinai have identified three major molecular subtypes of Alzheimer's disease (AD) using data from RNA sequencing. The study advances our understanding of the mechanisms of AD and could pave the way for developing novel, personalized therapeutics. (1.7.21) Full story
News Medical Life Sciences: The Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai and Rumi Scientific announced today that they will team up to initiate a drug discovery pipeline for rare genetic disorders that carry a high risk of autism. The Seaver Autism Center is led by Joseph Buxbaum, PhD, Professor of Psychiatry, Neuroscience, and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai. (1.6.21) Full story
STAT: A consortium of researchers led by Mount Sinai's Pei Wang, PhD, delved into the molecular details of 218 pediatric brain tumors, analyzing the genes, proteins, and RNA transcription that allow these cancers to proliferate. This analysis, which identified a number of unique proteins created by different types of brain tumors, allowed the researchers to draw connections between the presence of certain proteins and a patient’s prognosis. (11.25.20) Full story
HIT Consultant: Mount Sinai researchers have developed machine learning models that predict the likelihood of critical events and mortality in COVID-19 patients within clinically relevant time windows. (11.11.20) Full story
New York Times: New research including scientists from the Department of Genetics and Genomic Sciences, indicates that the coronavirus began to circulate in the New York area by mid-February, weeks before the first confirmed case, and that travelers brought in the virus mainly from Europe, not Asia. (4.8.20) Full story.
Noted Alzheimer’s researcher will assume new role on January 1, 2021
A team of data scientists, physicians, and engineers across the Mount Sinai Health System has come together to launch STOP COVID NYC, a web-based app to capture the symptoms and spread of COVID-19 in New York City
Researchers including Judy Cho and Eimear Kenny highlight genetic discoveries from over the past 25 years.
Researchers from the Department of Genetics and Genomic Sciences found Clonal evolution of a tumor ecosystem depends on different selection pressures that are principally immune and treatment mediated.
December 19, 2019 - NRXN1 undergoes extensive alternative splicing, and non-recurrent heterozygous deletions in NRXN1 are strongly associated with neuropsychiatric disorders. The study published in Nature Genetics reported links to patient-specific, heterozygous intragenic deletions in NRXN1 to isoform dysregulation and impaired neuronal maturation and activity in a human and disease-relevant context.
December 12, 2019 - Researchers at the Icahn School of Medicine at Mount Sinai have identified novel genes associated with the severity of peanut allergy, as well as ways in which these genes interact with other genes during allergic reactions. The findings, published in the Journal of Allergy and Clinical Immunology, could lead to better treatments for peanut allergy.
December 10, 2019 - A genetic variation believed to increase risk for heart failure in people of African or Latino ancestry has been identified in a new study by researchers from the Icahn School of Medicine at Mount Sinai and Perelman School of Medicine at the University of Pennsylvania. The study found that the transthyretin or TTR V122I genetic variant was significantly associated with heart failure and that heredity transthyretin amyloid cardiomyopathy (hATTR-CM) caused by this variant was confirmed at appreciable frequency in individuals of African or Latino ancestry. The results were published in JAMA.
November 25, 2019 - A process called sporulation that helps the dangerous bacterium Clostridium difficile (C. difficile) to survive inhospitable conditions and spread is regulated by epigenetics, factors that affect gene expression beyond the DNA genetic code, researchers at the Icahn School of Medicine at Mount Sinai report. This is the first discovery that epigenetics regulate sporulation in any bacteria. Their research, published November 25th in Nature Microbiology, opens a new window to developing treatments for this devestating infection.
November 20, 2019 - Scientists at the Icahn School of Medicine at Mount Sinai have uncovered new molecular drivers of Parkinson’s disease using a sophisticated statistical technique called multiscale gene network analysis (MGNA). The team was also able to determine how these molecular drivers impact the functions of genes involved in the disease. The results were published in Nature Communications.