Functional genomics combines genome-wide technologies, computational methods, and laboratory validations to systematically query the molecular mechanisms underlying human diseases.
Investigators in the Department of Genetics and Genomic Sciences (GGS) encompass a wide range of experimental and computational expertise and collaboratively apply functional genomics approaches to a wide range of diseases. Some recent achievements we have made include:
- Development of an approach for spatial functional genomics called Perturb-map to knockout dozens of genes in parallel in a mouse model of lung cancer and simultaneously assessed how each knockout influenced tumor growth, histopathology, and immune composition.
- Development and application of cutting-edge genomic technologies spanning bulk, single-cell, and spatial multi-omic technologies and data analysis and integration methods to generate, interpret, and integrate multi-dimensional, large-scale datasets to foster novel discovery and advance clinical applicability.
- Development of gene regulatory network approaches to gain functional understanding of disease associated genes and genetic variants at the cellular level.
- Applying multimodal neuroimaging techniques to facilitate the diagnosis of psychiatric disorders and the development of new medications.
Genetics and Genomic Sciences Faculty
- Samira Asgari, PhD | Lab Website
- Efrat Eliyahu, PhD
- Marie Fernandes, PhD
- Alison Goate, DPhil | Lab Website
- Benjamin Hopkins, PhD
- Sander Houten, PhD
- Wenyan Jiang, PhD | Lab Website
- Aiquin Li, PhD
- Sai Ma, PhD | Lab Website
- Edoardo Marcora, PhD
- Gaurav Pandey, PhD | Lab Website
- Lauren Peters, PhD
- Robert Sebra, PhD | Center Website
- Won-min Song, PhD | Lab Website
- Alexander Tsankov, PhD | Lab Website
- Meng Wu, PhD
- Guo-Cheng (GC) Yuan, PhD