Career Opportunities

The Seaver Autism Center for Research and Treatment is one of the most recognized institutions of its kind in the world because of its ability to translate breakthroughs in the lab to clinical trials that bring cutting-edge treatment to individuals affected by autism and other related neurodevelopmental disorders.

Our mission is to enhance the diagnosis of autism and related disorders, discover the biological causes of those disorders, and develop and disseminate breakthrough treatments.

Join our team to be a part of the scientific advances positively impacting children and families affected by autism worldwide.

Open Positions

Description

The laboratory of Silvia De Rubeis, PhD, at the Seaver Autism Center for Research and Treatment in the Department of Psychiatry at the Icahn School of Medicine at Mount Sinai in New York, is seeking an ambitious, creative, and motivated postdoctoral fellow with expertise in neuroscience to study the mechanisms underlying intellectual disability (ID) and autism spectrum disorder (ASD).

About the Job

Dr. De Rubeis’ laboratory aims at translating emerging genetic findings from large-scale genomic studies into functional analyses in cellular and mouse models with the goal of understanding the pathogenic underpinnings of ID and ASD. The laboratory focuses on two rare genetic disorders, DDX3X syndrome and ADNP syndrome, using cellular and animal models. Our team currently includes a postdoctoral fellow, two research associates, and an intern.

To learn more about our scientific interests, please see our publications:

We offer a 2-year position, renewable up to 5 years, with a competitive salary and benefit package. The candidate will have the opportunity to:

  • Conduct cutting-edge research with a strong translational impact for neurodevelopmental disorders;
  • Integrate the neuroscience expertise with genetics and genomics skills and be involved in large-scale genomic studies;
  • Be an active participant in the vibrant and exciting research community of the Seaver Center and the Icahn School of Medicine at Mount Sinai.

The Icahn School of Medicine at Mount Sinai offers convenient housing options for postdoctoral fellows. Postdocs also receive support from a dedicated Office of Postdoctoral Affairs. To learn more about postdoc services and resources, please visit the Office of Postdoctoral Affairs site.

About You

Basic qualifications:

  • PhD, MD, MD/PhD in Neuroscience/Molecular Biology/Cellular Biology;
  • Demonstrated expertise in neuroscience;
  • Strong record of publications in peer-reviewed journals;
  • Excellent communication skills;
  • Ability to work in an international and interdisciplinary team.

Preferred qualifications:

  • Prior experience with mouse models;
  • Experience with in utero manipulation techniques and/or stem cells biology;
  • Good understanding of genetics;
  • Familiarity with R and other statistical software.

How to Apply

Apply on the Mount Sinai Careers website (requisition number: 2447514) and e-mail a CV, cover letter detailing your research experience and interests, and contact information for 1-3 references to Dr. De Rubeis.

About the Job

Qualified candidates must be able to work collaboratively with a diverse team that includes senior research scientists, computational geneticists, molecular biologists, and support staff such as High Performance Computing (HPC) engineers, administrators and others. Strong candidates should be interested in genetics research, and capable of communicating results clearly and concisely, both verbally and in writing.

Specific responsibilities include

  • Develop and may perform a lead role for a variety of bioinformatics analysis projects, including genomic analyses of genotyping and sequencing data.

  • Conduct analysis of microarray and high-throughput sequencing data (including writing custom scripts), participate in experimental design and statistical analysis.

  • Manage and maintains databases of samples and genetic variants.

  • Participate in the preparation of manuscripts and presentations.

  • Collaborate with wet-bench biologists and geneticists and works independently to analyze data derived from several types of projects using microarrays and high-throughput sequencing.

  • Perform quality control and analysis.

  • Other related duties as assigned.

About You

We are looking for an ambitious, creative and motivated individual to join the Seaver Autism Center in this role. Specific qualifications include:

  • M.S. in Bioinformatics, Biomedical Informatics, Computational Biology, or Genomics Alternately, M.S. in a discipline requiring strong computational and analytical skills supplemented with some biology exposure

  • 2+ years post-graduate experience in a research environment, including the manipulation of large biological datasets

  • Advanced knowledge of genetics and/or statistical analysis software and online resources. Experience in programming environments such as MatLab, R statistical package, BioConductor, Perl and C++

  • Experience with large-scale data analysis problems (from any domain)

  • Excellent organizational skills, with demonstrated ability to productively work as a member of a team

  • Strong written and oral communication skills

  • Experience analyzing high-throughput genomic datasets

  • Demonstrates strong statistical and biological programming proficiency with proven expertise in genomic analysis and advanced knowledge of analytical methodologies

  • Ability to complete tasks efficiently and independently, and respond effectively to time pressure

Desirable background and skills

  • Previous research experience

  • PhD in a related field preferred. However, those with a Bachelor’s degree and additional post-graduate experience will also considered

How to Apply

Apply on the Mount Sinai Careers website (requisition number: 2418362) and send a resume and cover letter outlining your qualifications and interest in this position to: Lynn Hendrickson, MBA.

About the Job

An Associate Researcher position is available in the laboratory of Dr. Hala Harony-Nicolas in the Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai (ISMMS) in New York.

Dr. Harony-Nicolas’s lab investigates neural and molecular mechanisms underlying the pathogenesis of ASD, with a particular focus on (1) studying the effect of ASD-associated mutations on brain systems and neural circuits of social behavior that may contribute to deficits in social behavior with the aim to identify targets for intervention, (2) assessing the effect of novel or FDA approved therapeutics using behavioral and electrophysiological outcome measures, and (3) improving drug delivery to the brain using cutting edge technologies. Dr. Harony-Nicolas’s lab uses transgenic ASD rat models and applies behavioral and molecular neuroscience approaches, genome wide transcriptional analysis, and chemo-genetic tools to dissect molecular pathways and neural circuits affected in ASD.

The Associate Researcher is an entry laboratory research position. Under moderate supervision by the PI and/or a senior researcher in the lab, the Associate Researcher will be responsible for rodent behavior experiments, rodent brain surgery, and for carrying out routine and standardized molecular experiments using techniques specific to the research projects. S/he will analyze experiment data and assist in interpreting moderately complex results and will typically conduct laboratory research. The position may also include lab and clerical support.

Specific responsibilities include

  • Conducts routine and standardized experiments using appropriate research techniques specific to subject matter of the research project. This includes taking a major role on projects that involve rodent behavioral testing as well as blood draw, perfusion and brain surgery in rodents.

  • Analyzes and assists in interpreting laboratory results of moderate complexity.

  • Maintains laboratory environment and assists in the upkeep of appropriate inventory; may include ordering of supplies.

  • Assists in the collection, analysis and review of experimental data for publication and presentation.

  • Participates in biweekly meetings of the lab as well as other scientifically-oriented meetings, seminars, and other activities.

  • Other duties as assigned.

About You

We are looking for an ambitious, creative and motivated individual to join the Seaver Autism Center in this role. Specific qualifications include:

  • Bachelor’s degree in neuroscience, neurobiology or related field required

  • 0-2 year of research/laboratory experience

  • A successful candidate will have experience in molecular and behavioral neuroscience approaches. Preferred applicants will have additional experience in stereotaxic surgeries and brain viral injections. Knowledge in R or other languages for statistical computing or graphics is a plus.

  • Excellent organizational, problem solving and analytical skills

  • Highly motivated and have the ability to work both independently and in a multidisciplinary team-oriented environment

  • Excellent verbal, written and interpersonal communication skills

  • Knowledge of standard research concepts

  • Experience with and understanding of molecular techniques, especially DNA/RNA/Protein Isolation, western blot analysis, PCR, and cloning

How to Apply

Apply on the Mount Sinai Careers website (requisition number: 2416924) and send a resume and cover letter outlining your qualifications and interest in this position to: Lynn Hendrickson, MBA.

Description

We are looking for an ambitious, creative and motivated postdoctoral fellow with expertise in cellular neuroscience, pluripotent stem cells and electrophysiology to study the neurobiological mechanisms underlying autism spectrum disorder using those iPSC models.

About the Job

Due to the complexity and heterogeneity of autism and lack of a proper human cellular model, animal models, either naturalistic, environmental, pharmacological or genetic, have traditionally been the preferred choice for investigating mechanisms underlying autism. However, these models have several conceptual and practical limitations for studying human neurodevelopment. The recent advent of patient-specific induced pluripotent stem cells (iPSCs) has allowed researchers to circumvent these obstacles and efficiently complement animal models by establishing human iPSC lines, which capture both the primary genetic lesion and the genetic background of patients and are therefore particularly useful for disorders with complex etiology, where genetic causes are usually multiple and complex. In vitro induction of iPSCs derived from patients into various neuronal and glial cell types, in monolayer cultures or in organoids, provides a powerful new tool to study the cellular and molecular causes of human disorders and test therapeutic strategies in the cell types most affected in these diseases. The Seaver Center has several ongoing programs aiming to model different complex neurogenetic disorders associated with autism including Phelan-McDermid Syndrome, FOXP1 Syndrome and ADNP Syndrome, using iPSCs.

Specific responsibilities include

  • Performing and supervising iPSC reprogramming
  • Creating genetically modified lines
  • Differentiating iPSC in different types of neuronal cells
  • Neuron phenotyping
  • RNA sequencing experiments
  • Collecting, analyzing, and reviewing experimental data for publication and presentation
  • Leading new experiments and techniques when needed
  • Supervising students and technicians in the lab
  • Perform other duties as required

About You

We are looking for an ambitious, creative and motivated individual to join the Seaver Autism Center in this role. Specific qualifications include:

  • Ph.D. or equivalent in Neuroscience, Neurobiology or a related discipline
  • Experience in cellular neuroscience, cell culture, iPSC reprogramming and differentiation, cell transfection.
  • Experience in gene expression manipulation including cell transfection, utilization of viruses, shRNAs, CRISP-Cas9 gene editing.
  • Preferred applicants will have additional experience in single cell and multi-electrode array electrophysiology.
  • Knowledge in R or other languages for statistical computing or graphics is a plus.
  • Highly motivated.
  • Strong communication and writing skills.
  • Ability to work both independently and in a multidisciplinary team-oriented environment.
  • Strong organizational skills and analytic ability.

How to Apply

Apply on the Mount Sinai Careers website (requisition number: 2428802) and e-mail a CV, a brief description of research experience and interests, and contact information for 1-3 references to: Lynn Hendrickson.