The Genetics and Genomics team at the Seaver Autism Center for Research and Treatment focuses on the discovery and functional characterizing of genes that lead to autism diagnosis. As one of the largest autism genomics research centers in the country, we are dedicated to the understanding, treatment, and cure of genetic/genomics diseases. Our Center is developing trials to see what treatment works for spectrum genes in an approached called precision medicine. At the Seaver Center, our research labs are independent but often collaborate on the same genetic disorders.
One of the early findings of autism is that it is largely caused by genetic factors. We’ve been able to look at samples of people with and without autism to determine the genes associated with autism. We co-lead an international team that has identified several hundred genes that when mutated can cause autism and are associated with high-risk of developmental delay.
More than one percent of individuals in the world have autism. Through our research, more than 200 genes have been discovered related to autism diagnosis. Thirty percent of patients with profound autism can be diagnosed through specific genes.
Current genomics research includes:
- Largest autism sequencing study identifies 102 genes associated with autism
In 2020, the largest genetic sequencing study of autism spectrum disorder identified more than 102 genes associated with a risk for autism. The study revealed significant progress in discovering the genes associated with autism from other genes associated with intellectual disability and developmental delay.
- Study of more than 150,000 people identifies genes strongly linked to autism and neurodevelopmental disorders
In a study of genes underlying eurodevelopmental differences, it was discovered that more than 70 genes are associated with autism and more than 250 genes also have strong links to the conditions. This analysis is the largest of its kind and includes more than 150,000 participants.