Core C provides state-of-the-art start-to-finish technologies for genomics, transcriptomics, epigenetic, and single-cell analysis of the skin in homeostasis and disease.
Core C Leadership
Director: Anne Bowcock, PhD, Professor of Dermatology, Oncological Sciences, and Genetics and Genomic Sciences
Co-Director: Robert Sebra, PhD, Associate Professor of Genetics and Genomic Sciences and Director of The Center for Advanced Genomics Technology.
Core C Services
Core C facilitates access to:
- Genomics technologies such as exome sequencing, whole-genome sequencing, and targeted capture
- Transcriptomic methods (bulk ribonucleic acid (RNA)-seq, poly(A) RNA-seq, and small RNA-seq)
- Long-read single-molecule sequencing (SMRT/PacBio) to facilitate analysis of structural changes in DNA and the precise identification of RNA isoforms due to altered splicing
- Epigenetic technologies such as assay for transposase-accessible chromatin (ATAC) with high-throughput sequencing, chromatin immunoprecipitation (ChIP) -seq, and CUT&RUN) to identify DNA regulatory elements
- Single-cell (sc) technologies for transcript (scRNA-seq), epigenetic (scATAC-seq), and multiomics (scGEX+ATAC) analyses
- CITE-Seq technology for simultaneous epitope and transcriptome measurements of single cells
- Spatial transcriptomics analyses
Upon user request, data obtained by Core C will be supplied to SBDRC Resource Core D Data Analysis and Integration, where computational biologists will perform rigorous analysis, visualization, and data management.