Mount Sinai Skin Biology and Diseases Resource-Based Center (SBDRC)

SBDRC Resource Core B “Skin Disease Modeling”

The main objective of Core B is to offer specialized scientific, technical, and clinical expertise and services in advanced mouse and human skin research.

Core B Leadership

Director: Michael Rendl, MD, Professor of Cell, Developmental, and Regenerative Biology and Dermatology and Associate Director of the Black Family Stem Cell Institute

Associate Directors: Samuele Marro, PhD, Assistant Professor and co-director of the Stem Cell Engineering Core and Brian S. Kim, MD, MTR, Professor of Dermatology and Director of the Mark Lebwohl Center for Neuroinflammation and Sensation

Core B Services

Core B provides services including:

  • Provide clinical and histopathological expertise for easy retrieval and analysis of normal and diseased human skin.
  • Train and provide access to Multiplexed Fluorescence In situ Hybridization (merFISH) for spatial analyses of multiple proteins in skin disease studies.
  • Provide scientific expertise with genetic mouse models for analyzing mechanisms underlying skin development and homeostasis.
  • Consultation for isolation and analysis of skin cells by fluorescence activating cell sorting (FACS) technology.
  • Provide expertise with live imaging technology for ex vivo and in vivo skin cell behavior studies.
  • Provide support with multiplexed gene targeting with lentiviral intrauterine injection technology.
  • Provide expertise with neuronal calcium imaging.
  • Scientific expertise and services for human skin disease modeling with generation and characterization of patient-derived Induced pluripotent stem cells (iPSC).
  • CRISPR-based gene editing of human pluripotent stem cells (PSC) including the generation of fluorescent reporter alleles, loss-of-function alleles (knock-out), single-nucleotide changes (knock-in) and CRISPR-inhibition (CRISPRi) or CRISPR-activation (CRISPRa).
  • Differentiation of PSC to keratinocyte-like cells with transcriptional profile that closely resemble primary keratinocytes.
  • Differentiation of PSC to neuronal cells including glutamatergic and GABAergic neurons.
  • Differentiation of PSC to other cell types including immune-cells such as monocytes/macrophages and microglia.

To learn more about services involving physiological studies of mouse skin, please contact Dr. Rendl,

To learn more about iPSC/gene-editing services, please contact Dr. Marro, or visit the Stem Cell Engineering Core website.

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