The Atomic Force Microscopy Core Facility is supported by an NIH S10 shared instrument award, with funding from the American Recovery and Reinvestment Act. With state-of-the-art atomic force and real-time confocal imaging capabilities, the facility is customized for numerous biological applications ranging from single molecules, to living cells, to intact tissues.
The core functionality of the system allows users to conduct biomechanical studies complemented by fast, high-resolution confocal fluorescence imaging. As a standalone instrument, the atomic force microscope also provides force spectroscopy and imaging that break the optical resolution barrier, providing numerous user options. users.
Currently, eight Icahn School of Medicine at Mount Sinai research groups are major users of the facility, including those in cardiology, radiology, systems biology, structural biology, and orthopedics. Researchers use the system for high-resolution imaging, biomechanical testing, and single cell force probing, among numerous other applications.
Learn more about current AFM Core Research projects