Immune Regulation

Researchers in the Gumus Lab at the Department of Genetics and Genomics Sciences at the Icahn School of Medicine at Mount Sinai have developed a web-based tool for identifying human immune regulatory elements known as ImmuneRegulation.

Humans vary significantly in their baseline and activated immune phenotypes. The ImmuneRegulation portal provides access to complex immune regulation data for researchers interested in rapid and intuitive access to the effects of regulatory elements on gene expression in multiple studies. This allows researchers and investigators to translate rich data into biological insights and clinical applications.

ImmuneRegulation offers the largest centrally integrated resource on human transcriptome regulation across whole blood and blood cell types, including ~43,000 genotyped individuals with associated gene expression data from ~51,000 experiments, yielding genetic variant-gene expression associations on ~220 million expression quantitative trait loci (eQTLs); 14 million transcription factor (TF)-binding region hits extracted from 1,945 ChIP-seq studies; and the latest Genome-Wide Association Studies (GWAS) catalog with 67,230 published variant-trait associations. ImmuneRegulation, through its user-friendly open-access portal, enables users to interactively explore immune regulatory elements that drive cell-type or cohort-specific gene expression levels. 

ImmuneRegulation was developed as part of the Human Immunology Project Consortium (HIPC) program, funded by the NIAID Division of Allergy, Immunology, and Transplantation as part of the overall NIAID focus on human immunology. Through this program, well-characterized human cohorts are studied using a variety of modern analytic tools. ImmuneRegulation enables users to query analyses results on regulators of gene expression from multiple HIPC studies (e.g. Influenza vaccination, Chikungunya virus infection) together with major publicly available studies on regulatory elements in blood and blood cell types.

The ImmuneRegulation interface is designed to provide a user-friendly and effective tool for even first-time users. For this purpose, several curated example queries are available for users, which run with a single click, as well as use case tutorials for users to familiarize themselves with its functionalities. A frequently asked question (FAQs) section provides answers related to basic technical and scientific features. This is important to understand before applying this in your research. Finally, users can communicate all types of feedback (i.e. comments, questions, issues, and requests) to developers easily within the portal.

You can access the ImmuneRegulation portal using any standard web browser. A relevant paper detailing the ImmuneRegulation study and results were published in the web server issue of Nucleic Acids Research.

You can receive the latest updates and announcements by following ImmuneRegulation on Twitter.