Works In Progress

The Department of Pharmacological Sciences hosts a biweekly Works in Progress Discussion Series where trainees discuss their research ideas, design, results, and receive feedback in an informal setting. Two WiP presentations are held per session. This series is held on Thursdays at 11 am in a virtual format via Zoom. For presenting at the WiP Series, please contact DPS@mssm.edu.

2022

Date

Details

December 8

“Angiotensin Receptors and Vascular Disease”
Keiichi Asano (Ramirez Lab)

November 10

Describing Ligand Selectivity for Solute Carrier Transporters
Keino Hutchinson (Schlessinger Lab)

TBD
Yifei Sun (Walsh Lab)

October 27

“Design & Synthesis of BRD4/BRD2-ET Domain Targeting Compounds ”
Bharath Kumar Gajjela (Zhou Lab)

TBD
Carisse Lansiquot (Lazarus Lab)

October 13

TBD
Gregory Zilberg (Wacker Lab)

“Structural Signatures: Applying Patterns in Protein Structures to Tissue and Drug Characterization”
Nicole Zatorski (Schlessinger Lab)

September 29

“Predicting Gain and Loss of Function Variants with Machine Learning”
David Stein (Schlessinger & Itan Lab)

 

“Novel Methyltransferase Inhibitors and Degraders”
Julia Velez (Jin Lab)

 

September 15

“SARS-CoV-2 Envelope Protein and Human BRD2/4 Interaction Stimulates Cytokine Storm”
Anbalagan Jaganathan (Zhou Lab)

“Using Confirmation Sensitive Protein KInase C Antibody to Probe G Protein Coupled Receptor Signaling”
Achla Gupta (Devi Lab)

September 1

“Structural Studies of the Serotonin Receptor 5-HT1A in Complex with Psychedelic Drugs”
Audrey Warren (Wacker Lab)

August 4

“Develop the Novel Sequencing Technique CUT&Tag for Epigenomic Profiling of FOXI1 Utilizing Cystic Fibrosis as a Disease Model”
Wan Yee Lam (Walsh Lab)

Early Dissemination of Breast Cancer Cells
Carolina Rodriguez Tirado (Sosa Lab)

June 23

Predicting hiPSC-CMs Maturation Through Genetics and Electrophysiology
Rafael Dariolli (Sobie Lab)


“TBD”
Shakti Ingle (Bechhofer Lab)

June 2

TBD
Emily Teichman (Jin, Morel & Schlessinger Labs)

“SigCom LINCS: Gene Expression Signature Portal for Drug and Target Discovery”
John Erol Evangelista (Ma'ayan Lab)

May 12

TBD 
Jens Hansen (Iyengar Lab)

“Discovery of a First-in-class eEF1A2 Degraders for the Treatment of Metastatic Solid Tumors”
Md Kabir (Jin Lab)

March 31

“lncHUB2: Predicted Biological Functions and Drug/Disease Associations for lncRNAs” 
Megan Wojciechowicz (Ma’ayan Lab)

“Identification of ULK1 Activators”
Heather Dahlin (Lazarus Lab)

February 17

“Stabilizers and Destabilizers of the Protein-Protein Interaction”
Zaigham Khan (Dar Lab)

“Targeting Triple Negative Breast Cancer with VHL-recruiting EZH2 Protein Degrader”
Brandon Dale (Jin Lab)

January 20

“Welcome Address”
Ming-Ming Zhou, Ph.D.

“Molecular Mechanisms for CNS Axonal Regeneration – Extracellular Histones and Axonal mRNA-seq” 
Mustafa Siddiq, Ph.D. (Iyengar Lab)

2021

Date

Details

December 16

“Structural Signatures: Using Patterns of Structures in Expressed Proteins to Understand Underlying Biological Phenomena”
Nicole Zatorski (Schlessinger Lab)

November 18

“Rational Design of Small Molecules Targeting LAT1”
Keino Hutchinson (Schlessinger Lab)

“Role of TSH receptors in the brain”
Sari Miyashita (Zaidi Lab)

October 21

“Synthesis and pharmacology of a novel μ-δ opioid receptor heteromer selective agonist based on the carfentanyl template”
Ivone Gomes (Devi Lab)

“The Regulation of Pancreatic Cancer Cell Death Through Autophagy Inhibition”
Kisa Sung (Lazarus Lab)

September 23

“Structural and Biochemical Studies of a Pseudokinase ULK4”
Susmita Khamrui (Lazarus Lab)

“Pharmacological Characterization of Understudied Aminergic Receptors”
Gregory Zilberg (Wacker Lab)

September 9

“Discovery of First-in-class eEF1A2 Degraders for Pancreatic Cancer”
Md Kabir (Jin Lab)

“Markov State Model Analysis of Dynamic Dimerization Interfaces Between Transmembrane Domains of Metabotropic Glutamate Receptors”
Letty Salas-Estrada (Filizola Lab)

August 26

“First-in-Class Humanized FSH Blocking Antibody Targets Bone and Fat”
Sakshi Gera (Zaidi Lab)

July 1

“Mechanisms of Resistance and Sensitivity to TNBCs”
Arthur Chow (Dar Lab)

June 3

“Early Dissemination of Tumor Cells in Breast Cancer”
Carolina Rodriguez Tirado (Sosa Lab)

May 20

“Discovery and characterization of a fifth 3' exonuclease in Bacillus subtilis”
Shakti Ingle (Bechhofer Lab)

“Applying Single Cell RNA-Sequencing to Map the Cystic Fibrosis Airway and Chart the Cell Type-Specific Regulation and Expression of CFTR”
Megan Januska (Walsh Lab)

May 6

“Interaction of BRD2/BRD4 and E-protein of SARS-CoV2 Stimulates Cytokine Storm”
Anbalagan Jaganathan (Zhou Lab)

“A Perfluoroalkane Toolkit for Type II Kinase Inhibitors and Rational Polypharmacology”
Alex Scopton (Dar Lab)

April 22

‘Insights into kidney physiology from the Kidney Precision Medicine Project”
Jens Hansen (Iyengar Lab)

“Chemical Modulators of Polycomb Group Protein CBX7 for Prostate Cancer Therapy”
Nilesh Zaware (Zhou Lab)

March 25

‘Making the LINCS L1000 Data Look Like RNA-seq with Deep Learning”
Megan Wojciechowicz (Ma’ayan Lab)

“Fine Tuning of Opioid Receptor Signaling”
Mariana Lemos Duarte (Devi Lab)

March 11

‘Predicting Targets for 17 Types of Pain with Machine Learning”
Minji Jeon (Ma’ayan Lab)

“Structure-Based Drug Design of a HCN2 Channel-Selective Inhibitor with Antidepressant Activity”
Emily Teichman (Han/Jin Lab)

February 25

“Structural Basis for the Action of Anticancer Drug Trametinib”
Zaigham Khan (Dar Lab)

January 21

“Conversations with the Chair”
Ming-Ming Zhou, Ph.D.

“CRF in the Extended Amygdala Gates the Affective Experience of Depression”
Sherod Haynes (Han Lab)