Mount Sinai researchers continue to advance our knowledge about the underpinnings of human disease. The following scientific breakthroughs of 2018 reflect the innovative research being conducted in our labs.
Cancer Metastasis May Occur Before a Tumor Develops
(Nature Communications January 2, 2018) Julio Aguirre-Ghiso, PhD, Professor of Oncological Sciences, Otolaryngology, Medicine (Hematology and Medical Oncology)
Mount Sinai researchers have found that normal immune cells called macrophages, which reside in healthy breast tissue surrounding milk ducts, play a major role in helping early breast cancer cells leave the breast for other parts of the body, potentially creating metastasis before a tumor has even developed. The findings from this study could eventually pinpoint biomarkers to identify cancer patients who may be at risk of carrying potential metastatic cells due to these macrophages, and potentially lead to the development of novel therapies that prevent early cancer metastasis.
Possible Link Between Crohn’s and Parkinson’s Diseases
(Science Translational Medicine January 2, 2018) Inga Peter, PhD, Professor of Genetics and Genomic Sciences; and Judy H. Cho, MD, Director of the Institute for Personalized Medicine
People of Ashkenazi Jewish descent with Crohn’s disease have a high likelihood of carrying the LRRK2 gene mutation, a major genetic cause of Parkinson’s disease, according to research at the Icahn School of Medicine at Mount Sinai. The presence of shared LRRK2 mutations in patients with Crohn’s disease and Parkinson’s disease provides refined insight into disease mechanisms and may have major implications for the treatment of these two seemingly unrelated diseases. LRRK2 inhibitors being developed for Parkinson’s disease might help people with Crohn’s disease, while anti-inflammatory approaches could benefit Parkinson’s patients.
Large Scale Study Finds Genes Linked to Obesity
(Nature Genetics January 2018) Ruth Loos, PhD, Professor of Environmental Medicine and Public Health
Diet and physical activity are not the only factors that determine how easily a person gains or loses weight. Researchers at the Icahn School of Medicine at Mount Sinai and the Genetic Investigation of Anthropometric Traits (GIANT) consortium have found that 13 genes may play an important role as well. These 13 genes carry variations associated with body mass index (BMI). They act in the brain in pathways that may affect people’s food intake, hunger, and satiety, making it harder for people who inherit the variations to eat less or stop eating, when compared with individuals who did not inherit them.
Computational Model Leads to Discovery of Gene-Activation Pathway Associated with Atherosclerosis
(Nature Communications June 12, 2018) Jun Zhu, PhD, Professor of Genetics and Genomic Sciences, and Head of Data Science at Sema4
A computational model of cells that line blood vessels in the human heart that was developed at the Icahn School of Medicine at Mount Sinai, has led to the discovery of a gene-activation pathway caused by lipids associated with coronary artery disease. The new pathway could help identify new directions in research and drug development.
Unusually High Levels of Herpesviruses Found in the Alzheimer’s Disease Brain
(Nature Communications June 21, 2018) Joel Dudley, PhD, Director, Next Generation Healthcare Institute; Associate Professor, Genetics and Genomic Sciences, and Population Health Science and Policy; and Samuel Gandy, MD, PhD, Professor, Neurology, and Psychiatry; Associate Director, Alzheimer’s Disease Research Center, and Director, The Mount Sinai Center for Cognitive Health and NFL Neurological Care
Two strains of human herpesvirus—human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7) —are found in the brains of people with Alzheimer’s disease at levels up to twice as high as in those without Alzheimer’s, researchers from the Icahn School of Medicine at Mount Sinai report. The team also identified previously unknown gene networks that will offer new testable hypotheses for understanding Alzheimer’s pathology and reveal novel potential targets for new drugs that may arrest Alzheimer’s disease progression.
Discovery Could Lead to Higher Response Rates for Bladder Cancer Patients Treated with Immunotherapy
(Oncogene July 2018) Matthew Galsky, MD, Professor, Medicine (Hematology and Medical Oncology) and Urology; and Medical Director, Genitourinary Medical Oncology, The Tisch Cancer Institute; and Jun Zhu, PhD, Professor, Genetics and Genomic Sciences; and Head, Data Sciences, Sema4
Mount Sinai researchers have discovered that a particular type of cell present in bladder cancer may be the reason why so many patients do not respond to the groundbreaking class of drugs known as PD-1 and PD-L1 immune checkpoint inhibitors, which enable the immune system to attack tumors. The researchers are now trying to validate the gene expression identified in their study as a biomarker that could help refine clinical trials and treatment in the future by predicting the level of response or resistance to PD-1/PD-L1 inhibitors.
Improving the Prognosis for Melanoma
(Nature Communications August 24, 2018) Emily Bernstein, PhD, Associate Professor, Oncological Sciences, and Dermatology
A novel epigenetic mechanism that causes resistance to the standard treatment given to melanoma patients with mutations in the BRAF gene has been discovered by Emily Bernstein, PhD, and her team of researchers at the Icahn School of Medicine. BRAF mutations are found in roughly half of all melanomas. The researchers also found a biomarker–a protein called IGFBP2– that is associated with poor prognosis in melanoma patients. The findings point to a potential, multi-pronged approach to preventing drug resistance or reversing it once it has occurred by inhibiting the effects of BRAF mutations and IGFBP2-driven biological pathways.
Mount Sinai Researchers Discover How to Restore Vision Using Retinal Stem Cells
(Nature, August 15, 2018) Bo Chen, PhD, Associate Professor, Ophthalmology; and Director, Ocular Stem Cell Program
Researchers at Mount Sinai have successfully restored vision in mice through activating retinal stem cells, something that has never been done before. This study opens a new pathway for potentially treating blinding diseases by manipulating our own regenerative capability to self-repair. The findings could advance efforts toward regenerative therapies for blinding diseases in humans, such as age-related macular degeneration and retinitis pigmentosa.
Artificial Intelligence Detects Acute Neurological Illness in Minutes
(Nature Medicine August 2018) Eric K. Oermann, MD, Instructor of Neurosurgery; and Joshua B. Bederson, MD, Professor and Chair of the Department of Neurosurgery
In the first study to use artificial intelligence to identify neurological disease, Mount Sinai researchers have designed an automated deep-learning neural network that can detect stroke, hemorrhage, and hydrocephalus within seconds, as compared to average human times of minutes. The research, which used more than 37,000 head CT scans, enables earlier intervention that can preserve neurological function and improve patient outcomes.
Patients with Diabetes and Advanced Heart Disease Lived Longer After Bypass Surgery Than Those Treated with Angioplasty
Valentin Fuster, MD, PhD, Professor, Medicine (Cardiology); Director, Mount Sinai Heart; and Physician-in-Chief, The Mount Sinai Hospital; and George Dangas, MD, PhD, Professor, Medicine (Cardiology) and Surgery
Patients who have diabetes and multivessel coronary artery disease that is treated with coronary-artery bypass grafting (CABG) survived about three years longer than similar patients who were treated with percutaneous coronary intervention with drug-eluting stents (PCI), according to researchers at the Icahn School of Medicine at Mount Sinai. The findings provide clear evidence that CABG plus standard medical therapy is the optimal treatment path for patients with diabetes and extensive coronary disease.