Current Research Studies

The following are the research studies currently underway at our Center. To get involved or to learn more about our research studies, please call 212-241-5152.

Biomarkers of Attention Function in Traumatic Brain Injury (TBI)

Principle Investigator: Dr. Sudhin Shah, PhD

The Brain Injury Research Center of Mount Sinai has teamed up with colleagues at Weill Cornell Medicine to compare measures of brain function with performance on tests of thinking abilities, and determine biomarkers related to impairments in attention after a TBI.

Eligibility: In order to take part in this study you must be at least 18 years of age, have had a TBI and documentation of injury (ex: a doctor’s note, ED visit or hospitalization), and you must be within 8-months of the injury.

Your Role: Participation includes two full day visits to Weill Cornell Medicine, one at 6 months after injury and one at 12 months after injury. The visits include MRI, EEG, blood draw, and tests of thinking ability.

The Late Effects in Traumatic Brain Injury (LETBI)

Principle Investigator: Dr. Kristen Dams-O’Connor, PhD

The LETBI study is designed to learn more about how the effects of traumatic brain injury (TBI) and aging. We are interested in learning more about the health conditions that people with TBI already have at the time of their injury, and we are interested in their health and cognitive functioning (thinking skills, such as memory or attention) after their injury. This study is unique in that it involves brain banking. Where participants will be asked regardless of their age, gender, or health condition, to consider brain donation at the end of life and to make their wishes know.

Eligibility: In order to take part in this study you must have had a TBI (mild, moderate or severe) and documentation of injury (ex: a doctor’s note, ED visit or hospitalization) and you must be at least 1 year post-injury.

Your Role: Participation includes a day visit to the Brain Injury Research Center at Mount Sinai Hospital. This visit includes an interview, questionnaires, blood draw and an MRI scan (if applicable). If you are unable to travel to the center, your participation over the phone is expected to last approximately two hours. You will be compensated at the end of each in person or phone visit.

Learn more about this study

The Online Emotion Regulation Intervention Following TBI (Online EMREG)

Principle Investigator: Dr. Maria Kajankova, PhD

The online EMREG study is designed for people who have had a TBI and are experiencing problems managing their emotions. The goal of the study is to provide individual with skills to help them better manage their emotions day-to-day in a group format. Instead of having people come into our office for the groups, we’re using an online video-conferencing program so people don’t have to travel to Mount Sinai Hospital and can access this valuable intervention.

Eligibility: In order to take part in this study you must have had a TBI at least six months ago. You must also have access to a computer or tablet with high-speed internet connection and have an active e-mail account.

Your Role: Participation will last for 28 or 40 weeks in total depending on the group to which you are randomly assigned. You will be compensated upon study completion.

Learn more about this study

The Ultrahigh Field MRI Detection of Biomarkers in Post-Traumatic Epilepsy (PTE)

Principal Investigator: Dr. Rebecca Feldman, PhD

The Ultrahigh Field MRI detection of biomarker in post-traumatic epilepsy (PTE) study is designed to investigate changes in brain tissue due to traumatic brain injury (TBI) or PTE without the need for invasive procedure.

Eligibility: In order to take part in this study you must be eligible for an MRI scan. You must also have had a TBI (mild, moderate or severe) and documentation of your injury (ex: a doctor’s note, ED visit or hospitalization).

Your Role: Participation includes one half day visit to Mount Sinai Hospital. The visit includes an interview, questionnaires, blood draw and an MRI scan. You will be compensated upon study completion.

Learn more about his study

TBI and Health in Adults: An Exploratory Study

Principal Investigator: Dr. Kristen Dams-O’Connor, PhD

The TBI and health in adults exploratory study is designed to learn more about traumatic brain injury (TBI) and aging. As is the case for adults without a TBI, individuals with a TBI may experience different health conditions as they age.

Eligibility: In order to take part in this study you must have had a TBI (mild, moderate or severe) and documentation of injury (ex: a doctor’s note, ED visit or hospitalization) and you must be at least 1 year post-injury.

Your Role: Participation includes follow-up by mail/phone every 1-2 years for the duration of the study. Participants will complete questionnaires about health and functioning and a brief neuropsychological assessment over the phone. You will be compensated $10 for completing each part of the study.

The following are research studies where research volunteers are directly recruited from our Traumatic Brain Injury rehabilitation unit. For more information, please call 212-241-5152.

The Traumatic Brain Injury Model System (TBIMS)

Principle Investigator: Dr. Kristen Dams-O’Connor, PhD

TBIMS program began in 1987 with a mission to improve care and outcomes for individuals with Traumatic Brain Injury (TBI). Through a rigorous review process, 16 hospitals were designated as TBIMS centers. All centers provide a multidisciplinary system of rehabilitation care, including emergency medical, acute medical and post-acute services. In addition to providing direct services, these centers play a pivotal role in building the national capacity for high-quality treatment and research serving people with TBI, their families, and the communities in which they reside.

Your Role: Participation includes completion of a phone interview 1, 2, and 5 years after injury and every 5 years thereafter. You will be compensated for each interview completed.

The Brain injury Rehabilitation: Improving the Transition Experience (BRITE)

Principle Investigator: Dr. Kristen Dams-O’Connor, PhD

The BRITE study is designed to learn more about how to best transition people from the hospital to outpatient care after TBI. Our goal is to achieve results that are important to patients with TBI, their families, and healthcare providers. The study assesses TBI patients and their support system over the course of 1 year. There are two possible study treatment groups: Rehabilitation Discharge Planning and Rehabilitation Transition Planning. Both groups provide all care you would normal receive at discharge; however, the transition plan has an additional 12 contacts from a TBI care manager over 6 months. Group assignment is random and we do not know if one group is better than the other.

Your Role: Participation is for TBI patients and caregivers, which includes random assignment to a treatment group and completion of a phone survey conducted at 3, 6, 9, and 12 months after discharge. You will be compensated for each interview completed.

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