Mount Sinai Neuropathology Brain Bank and Research CoRE

Research conducted using human post-mortem brain tissue remains a critical component of translational brain research programs. To meet the urgent need for this precious resource, the Neuropathology Brain Bank and Research CoRE at the Icahn School of Medicine at Mount Sinai offers comprehensive neuropathology services and maintains a brain bank focused on expanding collections related to aging, neurodegenerative disorders, traumatic brain injury, and COVID-19 encephalopathy.

The Neuropathology Brain Bank and Research CoRE, now encompassing the National Institutes of Health-funded Alzheimer’s Disease Research Center Neuropathology Core at Mount Sinai, aims to strengthen tissue-based translational research of devastating brain diseases by expanding the infrastructure needed to accelerate collection, characterization, and distribution of tissue and data to researchers.

Led by John F. Crary, MD, PhD, the CoRE was established in 2018 and has two complementary components. First, we provide a fully functional neuropathology-focused histology service for Mount Sinai Health System investigators, as well as for external researchers, including routine and special stains, as well as RNAScope and BaseScope. For researchers interested in histology services, including RNAScope and BaseScope, please contact Claudia DeSanctis, PhD, Senior Scientist and Histology Manager.

Secondly, the CoRE is focused on expanding collections of targeted areas, including aging, neurodegenerative disorders (e.g. Parkinson’s disease, atypical parkinsonism, Alzheimer’s disease, frontotemporal dementia, and other movement disorders), traumatic brain injury, and COVID-19 encephalopathy. For researchers interested in fresh, frozen, or fixed tissue blocks, please contact Emma Thorn, MA, Brain Bank and Research Manager.