Engineering the Future of Medicine
The Icahn School of Medicine at Mount Sinai has joined forces with Rensselaer Polytechnic Institute to develop the Center for Engineering and Precision Medicine (CEPM). The center is built on the premise that engineering is fundamental to understanding biomedical phenomena and developing the next generation of precision diagnostics and therapeutics. CEPM brings a diverse set of experts together in a single location in New York City to focus on research, education, and entrepreneurial translational science. By co-locating state-of-the-art engineering and medicine, the center is working toward solving society’s most intractable diseases, advancing individualized treatment, and improving quality of life for patients. In addition to research, the center strives to educate the next generation of biomedical researchers and develop pathways to commercialize the medicines and approaches it develops, to bring its efforts directly to the patient bedside. This center focuses on three general areas: immunoengineering, neuroengineering, and regenerative and reparative medicine.
Organizational Structure
The Center for Engineering and Precision Medicine is jointly staffed by Mount Sinai and Rensselaer.
Directors
Priti Balchandani, PhD
Dr. Balchandani is Professor, Diagnostic, Molecular, and Interventional Radiology; Neuroscience; Psychiatry; Director, Advanced Neuroimaging Research Program; Associate Director of the BioMedical Engineering and Imaging Institute
Deepak Vashishth, PhD
Dr. Vashishth is Yamada Corporation Professor and RPI Co-Director, Center for Engineering and Precision Medicine, Rensselaer Polytechnic Institute; and Adjunct Professor, Orthopedics, Icahn School of Medicine at Mount Sinai
Leadership Committee
The center boasts an active Leadership Committee, which includes the following members:
Icahn School of Medicine at Mount Sinai
- Zahi A. Fayad, PhD
Director, BioMedical Engineering and Imaging Institute; Professor, Diagnostic, Molecular, and Interventional Radiology, Medicine (Cardiology), AI and Human Health - Scott L. Friedman, MD
Dean, Therapeutic Discovery; Fishberg Professor of Medicine; Professor, Pharmacology and Systems Therapeutics; Chief, Division of Liver Diseases
Rensselaer Polytechnic Institute
-
Jonathan S. Dordick, PhD
Vice President, Strategic Alliances and Translation, Institute Professor, Chemical and Biological Engineering and Biological Sciences
In addition, faculty members from both educational institutions participate at varying levels, depending on their interests and availability. All CEPM faculty members belong to either Icahn Mount Sinai or RPI. They carry full teaching, research, and other responsibilities at their home institutions, in addition to their relationship with CEPM.
Physical Facility
The Center is located at 619 West 54th Street in midtown Manhattan. The facility houses offices and labs for faculty members, including both wet and dry labs. The wet labs are intended for working with liquids, biological matter, and chemicals. Dry labs serve the needs of computation, physics, and engineering. By sharing office and lab space, we increase collaboration, flexibility, and creativity across team members from both Icahn Mount Sinai and Rensselaer.
Research
CEPM is acutely aware of the accelerated pace of technological breakthroughs in precision medicine. This field integrates the fundamental complexity of biological systems (e.g., genomics, proteomics, metabolomics and systems analysis), data science and analytics, and engineering science and technologies to provide more accurate, precise, and individualized treatment modalities to patients. Precision medicine is particularly appropriate for more intractable conditions such as cancer and dementia. The more complex the disease, the greater the variety of disease manifestations. This increasing complexity, together with the need for a high degree of accuracy, precision, and computation, requires skills that lie at the heart of engineering and engineering science.
CEPM focuses primarily on three broad research areas:
- Neuroengineering: Minimally invasive control and regulation of central, peripheral, and autonomic nervous system function
- Immunoengineering: Modulating the immune systems to address cancer and infectious disease
- Regenerative and reparative medicine: Renewing and repairing tissue using the body’s healing mechanism
We study a range of conditions, diseases, and related technologies, and explore drug development, stem cell applications, cellular engineering, and computational neurobiology.
Using both wet and dry labs, CEPM focuses on the following areas:
- Artificial intelligence and machine learning applied to biomedical data
- Biomanufacturing
- Biomedical engineering
- Cellular engineering
- Engineering in a resilient immune system
- Microphysiological platforms for discovery and diagnostics
- Personalized tissue repair, drug discovery, and therapeutics
- Point-of-care and point-of-use devices and diagnostics
- Robotics
PhD in Health Sciences Engineering
The Center for Engineering and Precision Medicine supports a five-year PhD program jointly offered by the Icahn School of Medicine at Mount Sinai and Rensselaer Polytechnic Institute.
Through its multidisciplinary and immersive approach, the PhD in Health Sciences Engineering combines rigorous engineering coursework with hands-on clinical experience and entrepreneurship training. Our PhD candidates benefit from expert mentorship while working on real-world projects and participating in industry internships. Our curriculum emphasizes technical expertise in areas such as reparative and regenerative medicine, immunoengineering, and neuroengineering. Designed to help students bridge the gap between engineering and medicine, our graduates exit poised to transform health care as entrepreneurs and leaders.
Application Process for Health Sciences Engineering PhD
For those interested in pursuing the Health Science Engineering PhD, we have provided a detailed overview of the program. Please note that all applications are processed through Rensselaer Polytechnic Institute.
Translational Science
As part of our emphasis on translational science, a third arm of CEPM is the development labs, which represent the commercial outlet of our research. Our goal is to tie research efforts directly to improve patient care and quality of life. Through milestone-driven pre-venture support and early-stage venture and strategic investment financing, the value proposition of CEPM technologies is increased, thereby affording a greater return on investment to both the CEPM and society at large. We are partnering with biotech venture funds and biotech, pharma, and digital health care companies to develop biomedical technologies and products.
Entrepreneurship is also part of the CEPM’s educational programs. It involves educating our students in the economics, management, and commercialization of medical innovations. We emphasize ethics and professional norms, the role of regulatory bodies, communication, and the commercialization process for health care drugs and devices.