The Department of Medicine at the Icahn School of Medicine at Mount Sinai is home to a dynamic, mission‑driven research enterprise that stretches from molecular discovery to population health. Every day, investigators across our 14 divisions translate bold questions into rigorous science, from single-cell multiomics to reveal disease mechanisms, engineering devices that restore organ function, and leading multi‑center trials that redefine standards of care.
Backed by $150 million in National Institutes of Health (NIH) funding in 2025 with over 800 active grants and contracts, our faculty leverages state‑of‑the‑art cores, expansive clinical networks, and a collaborative culture that accelerates the journey from idea to impact. Discoveries move swiftly from bench to bedside, and into the communities we serve, ensuring that innovation drives tangible improvements in health equity and patient outcomes.
The Department of Medicine Office of Research, Icahn School of Medicine provides the scaffolding that allows curiosity to flourish, connecting investigators with resources and cultivating the next generation of physician‑scientists through structured mentoring and career‑development programs. Together, we are forging new paths to prevent, diagnose, and treat disease while training the leaders who will shape medicine’s future.
At‑a‑Glance
- 14 clinical and research divisions drive discovery from molecules to population health.
- More than 800 active externally‑funded projects that span basic, translational, clinical, and data‑science investigation.
- $150 million in FY‑2025 NIH funding positions our Department as 10th nationally in the Blue Ridge Institute for Medical Research rankings.
- More than 100 industry and federally‑sponsored clinical trials are coordinated through our dedicated Clinical Trials Office.
- A vibrant pipeline of 15+ NIH K‑awardees is supported by structured mentoring, grantsmanship workshops, and biostatistics cores.
Our Mission
To catalyze transformative research that improves human health by nurturing investigators, fostering interdisciplinary collaboration and rapidly translating discovery into equitable patient care.
Research Strengths Across the Divisions
Below is a snapshot of signature programs; explore divisional pages for full details.
- Cardiology – Mechanistic and imaging research through the Cardiovascular Research Institute and the Mount Sinai BioMedical Engineering and Imaging Institute propel innovations in devices, heart‑failure therapeutics, and prevention.
- Clinical Immunology – National leadership in primary immunodeficiency, asthma/allergy and B‑cell and T‑cell biology drives novel immunotherapies.
- Data‑Driven and Digital Medicine (D3M) – Pioneers multi‑modal AI models that predict disease incidence, integrate social determinants, and advance explainable machine learning.
- Endocrinology, Diabetes, and Bone – Home to the federally‑funded New York Nutrition and Obesity Research Center, Mount Sinai Diabetes, Obesity, and Metabolism Institute (DOMI), and first statewide artificial‑pancreas trial.
- Gastroenterology – World‑renowned inflammatory bowel disease (IBD) genetics, mucosal immunology, and colorectal‑cancer prevention research.
- General Internal Medicine – Focus on cancer survivorship, chronic‑disease self‑management, COVID‑19 outcomes, and aging disparities across 50+ studies.
- Genomic Medicine – Integrates large‑scale sequencing with clinical phenotypes to drive precision diagnostics and risk prediction.
- Hematology and Medical Oncology – Bench‑to‑bedside advances in myelodysplastic syndrome, gene therapy and mini‑BMT techniques, cancer research affiliated with The Tisch Cancer Institute, and National Cancer Institute-designated cancer center.
- Hospital Medicine – Innovates in quality, safety and digital tools (e.g., machine learning to predict health care-associated infections, voice‑recognition to cut burnout).
- Infectious Diseases – Multidisciplinary HIV, COVID‑19, transplant‑infection and emerging‑pathogen programs anchored by Global Health and Emerging Pathogens Institute.
- Liver Diseases – NIH/CDC‑funded metabolic dysfunction-associated steatotic liver disease, viral‑hepatitis, and World Trade Center‑exposure cohorts accelerate prevention and therapeutics.
- Nephrology – Leading discoveries in transplant nephrology, kidney fibrosis, and molecular therapeutics.
- Pulmonary, Critical Care, and Sleep – Genomics‑guided lung‑cancer endotyping, severe‑asthma trials and integrative sleep‑medicine research.
- Rheumatology – Precision immunology collaborations power CAR‑T trials for lupus and novel autoimmune gene discovery.
Infrastructure and Investigator Support
- Clinical Trials Office – End‑to‑end support from budget negotiation through reporting for more than 100 active trials.
- Grant Lifecycle Services – Divisional pre‑award and post-award teams, Biostatistics, Epidemiology, and Research Design biostatistics program, and "Reach‑for‑Your‑K/R" workshops streamline submissions.
- Mentoring Framework – Two‑mentor committees, Individual Development Plans and annual Vice‑Chair reviews guide instructors/assistant professors toward R01 independence.
- Education and Community – Weekly Grand Rounds, monthly Department of Medicine (DOM) Research Conference, Works‑in‑Progress series and the annual DOM Research Day showcase scholarship at every career stage.
Looking Ahead
With a growing Health System footprint, state‑of‑the‑art cores, and an unwavering commitment to mentorship, the Department of Medicine Office of Research is poised to accelerate breakthroughs that advance equitable health locally and globally.
Explore our labs, trials, and funding opportunities, or contact us at domresearch@mssm.edu to learn more.