Epigenetic regulation is critical for inducing and maintaining pluripotency of various stem cell populations, and for determining cell fate decisions.
Members of the Black Family Stem Cell Institute faculty study various epigenetic processes across a wide range of biological systems, including embryonic stem cell totipotency and pluripotency; somatic cell reprogramming; differentiation towards distinct lineages, such as various epithelial cell compartments and red blood cells; and cancer.
We study epigenetic mechanisms such as regulation by histone modifiers including but not limited to histone deacetylases, arginine and lysine methyltransferases, and Polycomb repressive complexes; DNA methylation; histone variants; and transcription factors, including lineage-specific and pluripotency factors. Institute staff use a wide range of tools to study these epigenetic mechanisms entailing genomic, epigenomic, and proteomic approaches; mouse modeling; high throughput screens; and genome editing.
Investigators with a major focus in epigenetics include: