In the Center for Advancement of Blood Cancer Therapies, we emphasize research that uses human models of normal and malignant hematopoiesis: primary human cells, ex vivo 2D and 3D cultures, patient-derived xenografts, bone marrow organoids and human pluripotent stem cells (hPSCs, including induced pluripotent stem cells, iPSCs and embryonic stem cells, ESCs). 

Major Research Areas: 

• Human pluripotent stem cell (hPSC)-derived hematopoiesis and Development of the hematopoietic system 
  Christopher Sturgeon, PhD, Eirini Papapetrou, MD, PhD

• Synthetic models of human leukemogenesis- CRISPR
  Elvin Wagenblast, PhD, Eirini Papapetrou, MD, PhD, David Dominguez-Sola, MD, PhD

• Induced pluripotent stem cell (iPSC) modeling of myeloid malignancies 
  Eirini Papapetrou, MD, PhD, Christopher Sturgeon, PhD, Bridget Marcellino, MD, PhD

• Translational and clinical research
  Ronald Hoffman, MD, John Mascarenhas, MD, Lewis Silverman, MD, Samir Parekh, MBBS

• Clonal hematopoiesis
  Eirini Papapetrou, MD, PhD, Alan Shih, MD, PhD, Bridget Marcellino, MD, PhD

• Hematopoietic stem cells in normal hematopoiesis and malignancies
  Ronald Hoffman, MD, Saghi Ghaffari, MD, PhD, Alan Shih, MD, PhD, Christoph Schaniel, PhD

• Cell therapies
  Christopher Sturgeon, PhD, Ronald Hoffman, MD, Brian D. Brown, PhD, Amir Horowitz, PhD, Joshua Brody, MD, Lucas Ferrari de Andrade, PhD, Camelia Iancu-Rubin, PhD

• Disorders of erythropoiesis
  James Bieker, PhD, Yelena Z. Ginzburg, MD