In the Center for Advancement of Blood Cancer Therapies, we emphasize research that uses human models of normal and malignant hematopoiesis: primary human cells, ex vivo 2D and 3D cultures, patient-derived xenografts, bone marrow organoids and human pluripotent stem cells (hPSCs, including induced pluripotent stem cells, iPSCs and embryonic stem cells, ESCs).
Major Research Areas:
- Human pluripotent stem cell (hPSC)-derived hematopoiesis and Development of the hematopoietic system
Christopher Sturgeon, PhD, Eirini Papapetrou, MD, PhD
- Synthetic models of human leukemogenesis- CRISPR
Elvin Wagenblast, PhD, Eirini Papapetrou, MD, PhD, David Dominguez-Sola, MD, PhD
- Induced pluripotent stem cell (iPSC) modeling of myeloid malignancies
Eirini Papapetrou, MD, PhD, Christopher Sturgeon, PhD, Bridget Marcellino, MD, PhD
- Translational and clinical research
Ronald Hoffman, MD, John Mascarenhas, MD, Lewis Silverman, MD, Samir Parekh, MBBS
- Clonal hematopoiesis
Eirini Papapetrou, MD, PhD, Alan Shih, MD, PhD, Bridget Marcellino, MD, PhD
- Hematopoietic stem cells in normal hematopoiesis and malignancies
Ronald Hoffman, MD, Saghi Ghaffari, MD, PhD, Alan Shih, MD, PhD, Christoph Schaniel, PhD
- Cell therapies
Christopher Sturgeon, PhD, Ronald Hoffman, MD, Brian D. Brown, PhD, Amir Horowitz, PhD, Joshua Brody, MD, Lucas Ferrari de Andrade, PhD, Camelia Iancu-Rubin, PhD
- Disorders of erythropoiesis
James Bieker, PhD, Yelena Z. Ginzburg, MD