Marc and Jennifer Lipschultz Precision Immunology Institute

Publications

Recent Featured Publications

2022

SCIENCE IMMUNOLOGY

Immunoglobulin A antibody composition is sculpted to bind the self gut microbiome.

2022-07

Yang, et al.

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NATURE BIOTECHNOLOGY

Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR.

2022-06

Schwarz, et al.

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NATURE 

Brain motor and fear circuits regulate leukocytes during acute stress.

2022-05

Poller, et al.

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NATURE MEDICINE

Neoadjuvant clinical trials provide a window of opportunity for cancer discovery

2022-03

Marron, et al.

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CELL

Spatial CRISPR genomics identifies regulators of the tumor microenvironment

2022-03

Dhainaut, et al.

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THE LANCET GASTROENTEROLOGY & HEPATOLOGY

Neoadjuvant cemiplimab for resectable hepatocellular carcinoma: a single-arm, open-label, phase 2 trial

2022-03

Marron, et al.

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NATURE MEDICINE

Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity

2022-02

Uzzan, et al.

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2021

NATURE MICROBIOLOGY

Precise quantification of bacterial strains after fecal microbiota transplantation delineates long-term engraftment and explains outcomes

2021-09

Aggarwala, et al.

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CELL

Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death

2021-08

Taft, et al.

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NATURE

Tissue-resident macrophages provide  pro-tumorigenic niche to early NSCLC cells.

2021-06

Casanova-Acebes, et al.

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NATURE IMMUNOLOGY

A microRNA expression and regulatory element activity atlas of the mouse immune system.

2021-06

Rose, et al.

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NATURE MEDICINE

BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology

2021-05

Bigenwald, et al.

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NATURE 

A myeloid-stromal niche and gp130 rescue in NOD2-driven Crohn’s disease

2021-05

Nayar, et al.

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NATURE IMMUNOLOGY

Dynamic regulation of B cell complement signaling is integral to germinal center responses

2021-05

Cumpelik, et al.

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NATURE CANCER

Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders

2021-03

Wu, et al.

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CANCER DISCOVERY

A critical role for Fas-mediated off-target tumor killing in T-cell immunotherapy

2021-03

Upadhyay, et al.

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CANCER DISCOVERY

Exploiting allosteric properties of RAF and MEK inhibitors to target therapy-resistant tumors driven by oncogenic BRAF signaling

2021-02

Adamopoulos, et al.

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2022

Allergy. Predicting probability of tolerating discrete amounts of peanut protein in allergic children using epitope-specific IgE antibody profiling.

The Journal of Allergy and Clinical Immunology: In Practice. Ocular Manifestations in Primary Immunodeficiency Disorders: A Report from the United States Immunodeficiency Network (USIDNET) Registry

Journal of Allergy and Clinical Immunology. Structural insights into MRGPRX2: A new vision of itch and allergy.

2021

International Archives of Allergy and Immunology. Mapping sequential IgE-binding epitopes on major and minor egg allergens.

Journal of Allergy and Clinical Immunology. Allergen-specific T cells and clinical features of food allergy: Lessons from CoFAR immunotherapy cohorts.

The Journal of Allergy and Clinical Immunology: In Practice. Bringing the next generation of food allergy diagnostics into the clinic.

The Journal of Allergy and Clinical Immunology: In Practice. A historical perspective on the substantial progress in understanding eosinophilic gastrointestinal disease.

Journal of Allergy and Clinical Immunology. Anaphylaxis knowledge gaps and future research priorities: A consensus report.

Allergy. Accurate and reproducible diagnosis of peanut allergy using epitope mapping.

The Journal of Allergy and Clinical Immunology. Severity grading system for acute allergic systems: A multidisciplinary Delphi study.

Allergy. A novel approach to the basophil activation test for characterizing peanut allergic patients in the clinical setting.

The Journal of Allergy and Clinical Immunology. Evolution of epitope-specific IgE and IgG4 antibodies in children enrolled in the LEAP trial.

 

2022

Cancer Discovery. Spatial positioning and matrix programs of cancer-associated fibroblasts promote T cell exclusion in human lung tumors.

Blood Advances. Sequencing T-cell redirection therapies leads to deep and durable responses in relapsed/refractory myeloma patients.

Clinical Lymphoma, Myeloma & Leukemia. High dimensional immune profiling of smoldering multiple myeloma distinguishes distinct tumor microenvironments.

Journal for Immunotherapy of Cancer. Integrated use of PD-1 inhibition and transarterial chemoembolization for hepatocellular carcinoma: evaluation of safety and efficacy in a retrospective, propensity score-matched study.

JCO Precision Oncology.  A three-gene signature predicts response to selinexor in multiple myeloma.

Cancer Cell. Augmentation of humoral and cellular immune responses after third-dose SARS-CoV-2 vaccination and viral neutralization in myeloma patients.

Nature Medicine. Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery.

Cell. Spatial CRISPS genomics identifies regulators of the tumor microenvironment.

The Lancet Gastroenterology & Hepatology. Neoadjuvant cemiplimab for resectable hepatocellular carcinoma: a single-arm, open-label, phase 2 trial.

Nature Reviews Immunology. Exhausted T cell phenotypes depend on TCR signal strength.

Journal for Immunotherapy of Cancer. Neoantigen vaccine-induced CD4 T cells confer protective immunity in a mouse model of multiple myeloma through activation of CD8 T cells against non-vaccine, tumor-associated antigens.

2021

Nature Medicine. Neurocognitive and hypokinetic movement disorder with features of parkinsonism after BCMA-targeting CAR-T cell therapy.

Blood. (Distinct) origins of IgM myeloma.

Nature Reviews Immunology. Not just neighbours: positive feedback between tumour-associated macrophages and exhausted T cells.

Science Advances. Patient similarity network of newly diagnosed multiple myeloma identifies patient subgroups with distinct genetic features and clinical implications.

Cancer Cell. Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification.

Nature Reviews Gastroenterology & Hepatology. Decoding therapy resistance in liver tumours: a giant leap.

Cancer Cell. Variable cellular responses to SARS-CoV-2 in fully vaccinated patients with multiple myeloma.

Expert Opinion on Therapeutics Targets. New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD).

Frontiers in Immunology. Lynch syndrome and MSI-H cancers: from mechanisms to “off-the-shelf” cancer vaccines.

Cancer Research. A novel long noncoding RNA finetunes the DNA damage response in hepatocellular carcinoma.

Nature Cancer. Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders.

Blood Cancer Journal. A phase 1b dose-escalation/expansion study of BET inhibitor RO6870810 in patients with advanced multiple myeloma.

Hematological Oncology.  On the relevance of immunodeficiency evaluation in haematological cancer.

Cancer Cell.  Tumor organoid-originated biomarkers predict immune response to PD-1 blockade.

Bone Marrow Transplantation.  Mesenchymal stromal cell therapy induces high responses and survival in children with steroid refractory GVHD and poor risk biomarkers.

STAR Protocols. A T-cell-based immunogenicity protocol for evaluating human antigen-specific responses.

Nature. Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells.

Cancer Cell. Macrophage-tumor cell intertwine drives the transition into a mesenchymal-like cellular state of glioblastoma.

JCI Insight. MMP2 and TLRs modulate immune responses in the tumor microenvironment.

Brain. Platelet-derived growth factor beta is a potent inflammatory driver in paediatric high-grade glioma.

Cancer Discovery. A critical role for fas-mediated off-target tumor killing in T-cell immunotherapy.

Journal for Immunotherapy of Cancer. Landscape of natural killer cell activity in head and neck squamous cell carcinoma.

Cancer Discovery. Exploiting allosteric properties of RAF and MEK inhibitors to target therapy-resistant tumors driven by oncogenic  BRAF signaling.

Acta Neuropathologica Communications. Macrophages and microglia: the cerberus of glioblastoma.

Frontiers in Immunology. Tumor-intrinsic mechanisms regulating immune exclusion in liver cancers.

Nature Medicine. BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology.

The Journal of Clinical Investigation. Vaccines for immunoprevention of cancer.

Nature Reviews Cancer. Therapeutic cancer vaccines.

Brain. Tumor immune landscape of paediatric high-grade gliomas.

Trends in Immunology. Uncloaking breast tumor neoantigens with radiation.

Nature Reviews Immunology. Taking CAR T cells up a synthetic Notch.

Nature Medicine. Liver metastases inhibit immunotherapy efficacy.

Urologic Oncology: Seminars and Original Investigations. Bacillus Calmette-Guerin (BCG): Its fight against pathogens and cancer.

2022

Nature Biotechnology. Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR.

Frontiers in Immunology. Development of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients After 1273-mRNA SARS-CoV-2 Vaccination.

Kidney 360. COVID-19 in Patients with Glomerular Disease: Follow-Up Results from the IRoc-GN International Registry.

Journal of Crohn’s and Colitis. Impact of COVID-19 on healthcare resources utilization among patients with inflammatory bowel disease in the USA.

Frontiers in Immunology. Differences in humoral and cellular vaccine responses to SARS-CoV-2 in kidney and liver transplant recipients.

Nature Immunology. Pathological sequelae of long-haul COVID.

2021

Gastroenterology. Impact of medications on COVID-19 outcomes in inflammatory bowel disease: analysis of more than 6000 patients from an international registry.

Cell Reports.  Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naïve and COVID-19 recovered individuals.

Clinical Immunology. COVID-19 prevalence and outcomes in patients receiving biologic therapies at an infusion center in New York City.

Cell Host & Microbe. Children and SARS-CoV-2.

Scientific Reports.  Limited intestinal inflammation despite diarrhea, fecal viral RNA and SARS-CoV-2 specific IgA in patients with acute COVID-19.

Journal of Clinical Immunology. Atypical inflammatory syndrome triggered by SARS-CoV-2 in infants with Down syndrome.

Gastroenterology. Intestinal Host Response to SARS-CoV-2 infection and COVID-19 outcomes in patients with gastrointestinal symptoms.

Journal of Clinical Medicine. COVID-19 and the kidney: a worrisome scenario of acute and chronic consequences.

Frontiers in Immunology. The BCG vaccine for COVID-19: First verdict and future directions.

Journal of Crohn’s and Colitis. The impact of vedolizumab on COVID-19 outcomes among adult IBD patients in the SECURE-IBD registry.

Journal of Experimental Medicine. Highlights from a year in a pandemic.

Nature Reviews Immunology. Super(antigen) target for SARS-CoV-2.

Kidney International. Results from the IRoc-GN international registry of patients with COVID-19 and glomerular disease suggest close monitoring.

Genetics in Medicine. Individuals with Down syndrome hospitalized with COVID-19 have more severe disease.

The Journal of Allergy and Clinical Immunology: In Practice. Clinical outcomes and features of COVID-19 in patients with primary immunodeficiencies in New York City.

Gastroenterology. Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2-related disease.

2022

Gastroenterology. Neutralizing anti-GM-CSF autoantibodies recognize posttranslational glycosylations on GM-CSF years prior to diagnosis and predict complicated Crohn’s Disease.

Cellular & Molecular Immunology. IFN-γ + cytotoxic CD4 + T lymphocytes are involved in the pathogenesis of colitis induced by IL-23 and the food colorant Red 40.

Nature Medicine. Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity.

The Lancet Gastroenterology & Hepatology. Treat to target with ustekinumab for Crohn’s disease.

Inflammatory Bowel Diseases. The multiple waves of COVID-19 in patients with inflammatory bowel disease: a temporal trend analysis.

2021

EBioMedicine. From single-target to cellular niche targeting in Crohn's disease: intercepting bad communications

Advances in therapy. A Review of the Totality of Evidence for the Development and Approval of ABP 710 (AVSOLA), an Infliximab Biosimilar.

Gastroenterology. Impact of medications on COVID-19 outcomes in inflammatory bowel disease: analysis of over 6,000 patients from an international registry.

Clinical Gastroenterology and Hepatology. Ileal pouch anal anastomosis for the management of ulcerative colitis is associated with significant disability.

Gastroenterology. Common and rare variant prediction and penetrance of IBD in a large, multi-ethnic, health system-based biobank cohort.

Cell Host & Microbe. Immunoglobulin A targets a unique subset of the microbiota in inflammatory bowel disease.

Cell Metabolism. Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23.

Gastroenterology. COVID-19 and inflammatory bowel disease: lessons learned, practical recommendations, and unanswered questions.

Gastroenterology. Inflammed ulcerative colitis regions associated with MRGPRX2-mediated mast cell degranulation and cell activation modules, defining a new therapeutic target.

Gastroenterology. Rational combination therapy to overcome the plateau of drug efficacy in inflammatory bowel disease.

Inflammatory Bowel Diseases. Aging and IBD: A new challenge for clinicians and researchers.

Journal of Crohn’s and Colitis. Efficacy and safety of tofacitinib re-treatment for ulcerative colitis after treatment interruption: results from the OCTAVE clinical trials.

Nature. A myeloid-stromal niche and gp130 rescue in NOD2-driven Crohn’s disease.

Nature Reviews Gastroenterology & Hepatology. The intestinal barrier, an arbitrator turned provocateur in IBD.

Alimentary pharmacology & therapeutics. Machine learning identifies novel blood protein predictors of penetrating and structuring complications in newly diagnosed paediatric Crohn’s disease.

Clinical Gastroenterology and Hepatology. Effect of Concomitant Therapy With Steroids and Tumor Necrosis Factor Antagonists for Induction of Remission in Patients With Crohn’s Disease: A Systematic Review and Pooled Meta-analysis

 

 

2022

JCI Insight. Linking erythropoietin to Treg-dependent allograft survival through myeloid cells.

Immunity. Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation.

2021

Kidney International Reports.  Prolonged intradialytic hypoxemia is associated with functional disturbances in erythrocytes.

Frontiers in Immunology. CyTOF-enabled analysis identifies class-switched B cells as the main lymphocyte subset associated with disease relapse in children with idiopathic nephrotic syndrome.

Clinical Journal of the American Society of Nephrology. Two can be better than one.

Kidney International.  The spatially resolved transcriptional profile of acute T cell-mediated rejection in a kidney allograft.

Kidney International Reports.  Repository corticotropin injections promote clinical remission and regulatory T cell expansion in membranous nephropathy.

Transplant International. Chemotherapy, target therapy and immunotherapy: which drugs can be safely used in the solid organ transplant recipients?

Journal of the American Society of Nephrology. Erythropoietin reduces auto-and alloantibodies by inhibiting T follicular helper cell differentiation.

Transplant. T cell exhaustion in organ transplantation.

Nephron. Preventing coronavirus disease 2019 in kidney transplant recipients: where should we begin?

Journal of the American Society of Nephrology. Passage of the comprehensive immunosuppressive drug coverage for kidney transplant patients act – a chance to celebrate and reflect.

American Journal of Transplantation. Harnessing T cell exhaustion to improve solid organ transplant outcomes.

American Journal of Transplantation. A noninferiority design for a delayed calcineurin inhibitor substitution trial in kidney transplantation.

 

 

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