Precision Immunology Institute at Icahn School of Medicine at Mount Sinai (PrIISM)

Publications

Recent Featured Publications

2021

NATURE MICROBIOLOGY

Precise quantification of bacterial strains after fecal microbiota transplantation delineates long-term engraftment and explains outcomes

2021-09

Aggarwala, et al.

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CELL

Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death

2021-08

Taft, et al.

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NATURE

Tissue-resident macrophages provide  pro-tumorigenic niche to early NSCLC cells.

2021-06

Casanova-Acebes, et al.

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NATURE IMMUNOLOGY

A microRNA expression and regulatory element activity atlas of the mouse immune system.

2021-06

Rose, et al.

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NATURE MEDICINE

BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology

2021-05

Bigenwald, et al.

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NATURE 

A myeloid-stromal niche and gp130 rescue in NOD2-driven Crohn’s disease

2021-05

Nayar, et al.

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NATURE IMMUNOLOGY

Dynamic regulation of B cell complement signaling is integral to germinal center responses

2021-05

Cumpelik, et al.

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NATURE CANCER

Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders

2021-03

Wu, et al.

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CANCER DISCOVERY

A critical role for Fas-mediated off-target tumor killing in T-cell immunotherapy

2021-03

Upadhyay, et al.

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CANCER DISCOVERY

Exploiting allosteric properties of RAF and MEK inhibitors to target therapy-resistant tumors driven by oncogenic BRAF signaling

2021-02

Adamopoulos, et al.

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2020

CELL

Mapping systemic inflammation and antibody responses in multisystem inflammatory syndrome in children (MIS-C)

2020-09

Gruber, et al.

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IMMUNITY

Complex autoinflammatory syndrome unveils fundamental principles of JAK1 kinase transcriptional and biochemical function

2020-08

Gruber, et al.

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NATURE MEDICINE

An inflammatory cytokine signature helps predict COVID-19 severity and death

2020-08

Del Valle, et al.

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SCIENCE IMMUNOLOGY

Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells

2020-07

Grasset, et al.

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NATURE MEDICINE

Sampling the host response to SARS-CoV-2 in hospitals under siege

2020-07

Charney, et al.

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IMMUNITY

Immunology of COVID-19: Current state of the science

2020-06

Vabret, et al.

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NATURE

A conserved dendritic-cell regulatory program limits antitumour immunity

2020-03

Maier, et al.

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CELL HOST & MICROBE

Fecal IgA levels are determined by strain-level differences in Bacteroides ovatus and are modifiable by gut microbiota manipulation

2020-03

Yang, et al.

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THE NEW ENGLAND JOURNAL OF MEDICINE

JAK inhibitor therapy in a child with inherited USP18 deficiency

2020-01

Alsohime, et al.

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2021

Allergy. Accurate and reproducible diagnosis of peanut allergy using epitope mapping.

The Journal of Allergy and Clinical Immunology. Severity grading system for acute allergic systems: A multidisciplinary Delphi study.

Allergy. A novel approach to the basophil activation test for characterizing peanut allergic patients in the clinical setting.

The Journal of Allergy and Clinical Immunology. Evolution of epitope-specific IgE and IgG4 antibodies in children enrolled in the LEAP trial.

2020

Pediatric Allergy and Immunology. IgE and IgG4 binding to lentil epitopes in children with red and green lentil allergy.

Allergy. Ovomucoid epitope-specific repertoire of IgE, IgG4, IgG1, IgA1, and IgD antibodies in egg-allergic children.

The Journal of Allergy and Clinical Immunology. A 5-year summary of real-life dietary egg consumption after completion of a 4-year egg powder oral immunotherapy (eOIT) protocol.

The Journal of Allergy and Clinical Immunology. Induction of sustained unresponsiveness after egg oral immunotherapy compared to baked egg therapy in children with egg allergy.

The New England Journal of Medicine. Hereditary angioedema.  

The Journal of Allergy and Clinical Immunology. Long-term, open-label extension study of the efficacy and safety of epicutaneous immunotherapy for peanut allergy in children: PEOPLE 3-year results.

Allergy. Demonstration of distinct pathways of mast cell-dependent inhibition of Treg generation using murine bone marrow-derived mast cells.

The Journal of Allergy and Clinical Immunology. Tailored management of allergic diseases by age: one size does not fit all.

 

2021

Cancer Cell. Macrophage-tumor cell intertwine drives the transition into a mesenchymal-like cellular state of glioblastoma.

JCI Insight. MMP2 and TLRs modulate immune responses in the tumor microenvironment.

Brain. Platelet-derived growth factor beta is a potent inflammatory driver in paediatric high-grade glioma.

Cancer Discovery. A critical role for fas-mediated off-target tumor killing in T-cell immunotherapy.

Journal for Immunotherapy of Cancer. Landscape of natural killer cell activity in head and neck squamous cell carcinoma.

Cancer Discovery. Exploiting allosteric properties of RAF and MEK inhibitors to target therapy-resistant tumors driven by oncogenic  BRAF signaling.

Acta Neuropathologica Communications. Macrophages and microglia: the cerberus of glioblastoma.

Frontiers in Immunology. Tumor-intrinsic mechanisms regulating immune exclusion in liver cancers.

Nature Medicine. BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology.

The Journal of Clinical Investigation. Vaccines for immunoprevention of cancer.

Nature Reviews Cancer. Therapeutic cancer vaccines.

Brain. Tumor immune landscape of paediatric high-grade gliomas.

Trends in Immunology. Uncloaking breast tumor neoantigens with radiation.

Nature Reviews Immunology. Taking CAR T cells up a synthetic Notch.

Nature Medicine. Liver metastases inhibit immunotherapy efficacy.

Urologic Oncology: Seminars and Original Investigations. Bacillus Calmette-Guerin (BCG): Its fight against pathogens and cancer.

2020

Journal of Hepatology. Novel patient-derived preclinical models of liver cancer.

Frontiers in Immunology. Computational prediction and validation of tumor-associated neoantigens.

Cell Death & Disease. Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL).

Clinical Cancer Research. Mouse models of oncoimmunology in hepatocellular carcinoma.

Cancer Immunology Research. Combined vaccination with NY-ESO-1 protein, poly-ICLC, and montamide improves humoral and cellular immune responses in patients with high-risk melanoma.

Oncotarget. MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21Cip1.

Clinical Advances in Hematology & Oncology. Improving outcomes with checkpoint blockade in non-Hodgkin lymphoma.

 

2021

Journal of Clinical Immunology. Atypical inflammatory syndrome triggered by SARS-CoV-2 in infants with Down syndrome.

Gastroenterology. Intestinal Host Response to SARS-CoV-2 infection and COVID-19 outcomes in patients with gastrointestinal symptoms.

Journal of Clinical Medicine. COVID-19 and the kidney: a worrisome scenario of acute and chronic consequences.

Frontiers in Immunology. The BCG vaccine for COVID-19: First verdict and future directions.

Journal of Crohn’s and Colitis. The impact of vedolizumab on COVID-19 outcomes among adult IBD patients in the SECURE-IBD registry.

Journal of Experimental Medicine. Highlights from a year in a pandemic.

Nature Reviews Immunology. Super(antigen) target for SARS-CoV-2.

Kidney International. Results from the IRoc-GN international registry of patients with COVID-19 and glomerular disease suggest close monitoring.

Genetics in Medicine. Individuals with Down syndrome hospitalized with COVID-19 have more severe disease.

The Journal of Allergy and Clinical Immunology: In Practice. Clinical outcomes and features of COVID-19 in patients with primary immunodeficiencies in New York City.

Gastroenterology. Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2-related disease.

2020

Immunity. Immunology of COVID-19: Current state of the science.

Nature Reviews Immunology. Advancing scientific knowledge in times of pandemics.

Journal of Pain and Symptom Management. National outreach of telepalliative medicine volunteers for a New York City safety net system COVID-19 pandemic response.

Nature Medicine. Sampling the host response to SARS-CoV-2 in hospitals under siege.

Health Security. Working upstream in advance care planning in pandemic palliative care.

Nature. Sampling the host response to SARS-CoV-2 in hospitals under siege.

Cell. Mapping system inflammation and antibody responses in multisystem inflammatory syndrome in children (MIS-C).

Nature Medicine. An inflammatory cytokine signature helps predict COVID-19 severity and death.

2021

Clinical Gastroenterology and Hepatology. Ileal pouch anal anastomosis for the management of ulcerative colitis is associated with significant disability.

Gastroenterology. Common and rare variant prediction and penetrance of IBD in a large, multi-ethnic, health system-based biobank cohort.

Cell Host & Microbe. Immunoglobulin A targets a unique subset of the microbiota in inflammatory bowel disease.

Cell Metabolism. Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23.

Gastroenterology. COVID-19 and inflammatory bowel disease: lessons learned, practical recommendations, and unanswered questions.

Gastroenterology. Inflammed ulcerative colitis regions associated with MRGPRX2-mediated mast cell degranulation and cell activation modules, defining a new therapeutic target.

Gastroenterology. Rational combination therapy to overcome the plateau of drug efficacy in inflammatory bowel disease.

Inflammatory Bowel Diseases. Aging and IBD: A new challenge for clinicians and researchers.

Journal of Crohn’s and Colitis. Efficacy and safety of tofacitinib re-treatment for ulcerative colitis after treatment interruption: results from the OCTAVE clinical trials.

Nature. A myeloid-stromal niche and gp130 rescue in NOD2-driven Crohn’s disease.

Nature Reviews Gastroenterology & Hepatology. The intestinal barrier, an arbitrator turned provocateur in IBD.

Alimentary pharmacology & therapeutics. Machine learning identifies novel blood protein predictors of penetrating and structuring complications in newly diagnosed paediatric Crohn’s disease.

Clinical Gastroenterology and Hepatology. Effect of Concomitant Therapy With Steroids and Tumor Necrosis Factor Antagonists for Induction of Remission in Patients With Crohn’s Disease: A Systematic Review and Pooled Meta-analysis

2020

Clinical Gastroenterology and Hepatology. A user’s guide to de-escalating immunomodulator and biologic therapy in inflammatory bowel disease.

Journal of Crohn’s and Colitis. JAK inhibitors safety in ulcerative colitis: practical implications.

Gastroenterology. Deep remission at 1 year prevents progression of early Crohn’s disease.

Clinical Gastroenterology and Hepatology. Stopping mesalamine therapy in patients with Crohn’s disease starting biologic therapy does not increase risk of adverse outcomes.

Inflammatory Bowel Diseases. Association of biomarker cutoffs and endoscopic outcomes in Crohn’s disease: a post hoc analysis from the CALM study.

Alimentary Pharmacology and Therapeutics. Systematic review and meta-analysis: efficacy and safety of early biologic treatment in adult and paediatric patients with Crohn’s disease.

Clinical Gastroenterology and Hepatology. Effect of concomitant therapy with steroids and tumor necrosis factor antagonists for induction of remission in patients with Crohn’s disease: a systematic review and pooled meta-analysis.

Gastroenterology. Serum biomarkers identify patients who will develop inflammatory bowel diseases up to 5 years before diagnosis.

Gastroenterology. New blood marker of endoscopic disease activity – a step forward in treating Crohn’s disease to target?

Gastroenterology. Age is just a number-frailty associates with outcomes of patients with inflammatory bowel disease.

 

2021

Nature Immunology. A microRNA expression and regulatory element activity atlas of the mouse immune system.

Nature Immunology. Dynamic regulation of B cell complement signaling is integral to germinal center responses.

Immunity. MDSC: Markers, development, states, and unaddressed complexity.

Journal of Experimental Medicine.  DNMT3A haplosufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells.

Nature Reviews Immunology.  Innate IL-13 licenses dermal type 2 dendritic cells for efficient T helper 2 cell responses.

Nature Reviews Immunology.  Maternal infection programmes offspring immunity.

2020

Nature. A conserved dendritic-cell regulatory program limits antitumour immunity.

Biomarkers for Immunotherapy of Cancer. Multiplexed immunohistochemical consecutive staining on single slide (MICSSS): multiplexed chromogenic IHC assay for high-dimensional tissue analysis.

PNAS. High-complexity extracellular barcoding using a viral hemagglutinin.

ImmunoHorizons. HPK1 influences regulatory T cell functions.

Biomedical Chromatography. Development of an ultra-performance liquid chromatography-electrospray ionization-Orbitrap mass spectrometry method for determination of xanthopurpurin in rat plasma and its application to pharmacokinetic study.

Cell Systems. MHCflurry 2.0: improved pan-allele prediction of MHC class I-presented peptides by incorporating antigen processing.

Immunity. Complex autoinflammatory syndrome unveils fundamental principles of JAK1 kinase transcriptional and biochemical function.