2023

Allergy, Asthma & Clinical Immunology. A multicenter chart review of patient characteristics, treatment, and outcomes in hereditary angioedema: unmet need for more effectice long-term prophylaxis.

Allergy. IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases. 

2022

The Journal of Allergy and Clinical Immunology: In Practice. Autologous hematopoietic stem cell transplantation in Clarkson disease.

Allergy. Predicting probability of tolerating discrete amounts of peanut protein in allergic children using epitope-specific IgE antibody profiling.

The Journal of Allergy and Clinical Immunology: In Practice. Ocular Manifestations in Primary Immunodeficiency Disorders: A Report from the United States Immunodeficiency Network (USIDNET) Registry

Journal of Allergy and Clinical Immunology. Structural insights into MRGPRX2: A new vision of itch and allergy.

2023

Clinical Immunology. Profiling of mouse and human liver diseases identifies targets for therapeutic treatment of autoimmune hepatitis.

Frontiers in Immunology.Endogenous erythropoietin has immunoregulatory functions that limit the expression of autoimmune kidney disease in mice.

Clinical and experimental immunology. Combination therapy of a TRPV2 agonist with a TNF inhibitor achieves sustained suppression of disease severity and reduced joint damage.

2022

Journal of autoimmunity.Impaired central tolerance induces changes in the gut microbiota that exacerbate autoimmune hepatitis.

2023

Science Immunology.  Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1+ PD-1+ CD8 T cells.

Nature Nanotechnology.  Close the cancer-immunity cycle by integrating lipid nanoparticle-mRNA formulations and dendritic cell therapy.

Nature Medicine.  Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma.

Nature Immunology. TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer.

Journal of Clinical Investigation. A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression.

Frontiers in Immunology.  Multi-omic analysis of the tumour microenvironment shows clinical correlations in Ph1 study of atezolizumab +/- SoC in MM.

Journal for Immunotherapy of Cancer.  Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-priming.

Blood Advances. The utility of biomarkers in acute GVHD prognostication.

Nature Communications. Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma.

BJU International. Urine supernatant reveals a signature that predicts survival in clear-cell renal cell carcinoma.

NPJ Precision Oncology. Germline rare deleterious variant load alters cancer risk, age of onset and tumor characteristics.

Nature Communications. Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity.

2022

Nature Communications. Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity.

Blood. Interventions and outcomes of multiple myeloma patients receiving salvage treatment after BCMA-directed CAR T therapy.

Cancer Cell. NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer.

Cancer Immunology Research. Targeting macrophages with CAR T cells delays solid tumor progression and enhances antitumor immunity.

Cancer Discovery. Spatial positioning and matrix programs of cancer-associated fibroblasts promote T cell exclusion in human lung tumors.

Blood Advances. Sequencing T-cell redirection therapies leads to deep and durable responses in relapsed/refractory myeloma patients.

Clinical Lymphoma, Myeloma & Leukemia. High dimensional immune profiling of smoldering multiple myeloma distinguishes distinct tumor microenvironments.

Journal for Immunotherapy of Cancer. Integrated use of PD-1 inhibition and transarterial chemoembolization for hepatocellular carcinoma: evaluation of safety and efficacy in a retrospective, propensity score-matched study.

JCO Precision Oncology.  A three-gene signature predicts response to selinexor in multiple myeloma.

Cancer Cell. Augmentation of humoral and cellular immune responses after third-dose SARS-CoV-2 vaccination and viral neutralization in myeloma patients.

Nature Medicine. Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery.

Cell. Spatial CRISPS genomics identifies regulators of the tumor microenvironment.

The Lancet Gastroenterology & Hepatology. Neoadjuvant cemiplimab for resectable hepatocellular carcinoma: a single-arm, open-label, phase 2 trial.

Nature Reviews Immunology. Exhausted T cell phenotypes depend on TCR signal strength.

Journal for Immunotherapy of Cancer. Neoantigen vaccine-induced CD4 T cells confer protective immunity in a mouse model of multiple myeloma through activation of CD8 T cells against non-vaccine, tumor-associated antigens.

2023

The Journal of Allergy and Clinical Immunology: In Practice. Detection of SARS-CoV-2 antibodies in immunoglobulin products.

MDPI.  Maintenance of potent cellular and humoral immune responses in long-term hemodialysis patients after 1273-mRNA SARS-CoV-2 vaccination.

2022

Science Translational Medicine. A shift in lung macrophage composition is associated with COVID-19 severity and recovery.

Nature Biotechnology. Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR.

Frontiers in Immunology. Development of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients After 1273-mRNA SARS-CoV-2 Vaccination.

Kidney 360. COVID-19 in Patients with Glomerular Disease: Follow-Up Results from the IRoc-GN International Registry.

Journal of Crohn’s and Colitis. Impact of COVID-19 on healthcare resources utilization among patients with inflammatory bowel disease in the USA.

Frontiers in Immunology. Differences in humoral and cellular vaccine responses to SARS-CoV-2 in kidney and liver transplant recipients.

Nature Immunology. Pathological sequelae of long-haul COVID.

2021

JCI Insight. Circulating bioactive bacterial DNA is associated with immune activation and complications in common variable immunodeficiency.

European Journal of Haematology. Lymphoid malignancy in common variable immunodeficiency in a single-center cohort.

Cell. Human TBK1 deficiency leads to autoinflammation driven by TNK-induced cell death.

The Journal of Allergy and Clinical Immunology: In Practice. Clinical manifestations and outcomes of activated phosphoinositide 3-kinase δ syndrome from the USIDNET cohort.

The Journal of Allergy and Clinical Immunology: In Practice. IFN-γ receptor 2 deficiency initial mimicry of multisystem inflammatory syndrome in children (MIS-C)

2023

Inflammatory Bowel Diseases. Cancer screening in patients with inflammatory bowel disease: don’t forget the anus!

The New England Journal of Medicine. Upadacitinib induction and maintenance therapy for Crohn’s disease.

The Journal of Clinical Investigation. Selective IgA₂ deficiency in a patient with small intestinal Crohn’s disease.

Inflammatory Bowel Diseases. Acute Severe Ulcerative Colitis Is Associated With an Increased Risk of Acute Pouchitis.

Digestive Diseases and Sciences. Early Use of Biologics Reduces Healthcare Costs in Crohn's Disease: Results from a United States Population-Based Cohort.

Clinical Gastroenterology and Hepatology. Preclinical Serological Signatures are Associated With Complicated Crohn's Disease Phenotype at Diagnosis.

Gastroenterology. Anti-Integrin αvβ6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis.

2022

Gut. NOX1 is essential for TNFa-induced intestinal epithelial ROS secretion and inhibits M cell signatures.

Gastroenterology. Neutralizing anti-GM-CSF autoantibodies recognize posttranslational glycosylations on GM-CSF years prior to diagnosis and predict complicated Crohn’s Disease.

Cellular & Molecular Immunology. IFN-γ + cytotoxic CD4 + T lymphocytes are involved in the pathogenesis of colitis induced by IL-23 and the food colorant Red 40.

Nature Medicine. Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity.

The Lancet Gastroenterology & Hepatology. Treat to target with ustekinumab for Crohn’s disease.

Inflammatory Bowel Diseases. The multiple waves of COVID-19 in patients with inflammatory bowel disease: a temporal trend analysis.

2023

iScience. Oral vancomysin treatment suppresses gut trypsin activity and preserves intestinal barrier function during EAE.

Psychiatry Research.  Gut and oral microbiome modulate molecular and clinical markers of schizophrenia-related symptoms: A transdiagnostic, multilevel pilot study.

eBioMedicine. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome.

Proceedings of the National Academy of Sciences. Species-specific CD4⁺ T cells enable prediction of mucosal immune phenotypes from microbiota composition.

2022

Cell Host & Microbe. Human gut microbiota stimulate defined innate immune responses that vary from phylum to strain.

Microbiome. Mining the microbiota to identify gut commensals modulating neuroinflammation in a mouse model of multiple sclerosis.

Science Immunology. Immunoglobulin A antibody composition is sculpted to bind the self gut microbiome.

2023

The Journal of Allergy and Clinical Immunology.  Difelikefalin suppresses itch and reduced scratching independent of inflammation in a murine model of atopic dermatitis.

Lancet. An anti-OX40 antibody to treat moderate-to-severe atopic dermatitis: a multicentre, double-blind, placebo-controlled phase 2b study.

Journal of the European Academy of Dermatology and Venereology. Pharmacology of orismilast, a potent and selective PDE4 inhibitor.

The New England Journal of Medicine. Phase 2 Trial of Difelikefalin in Notalgia Paresthetica.

2021

Dermatologic Therapy. Good Practice Intervention for Clinical Assessment and Diagnosis of Atopic Dermatitis: Findings from the Atopic Dermatitis Quality of Care Initiative

2023

Kidney360.  Decay-accelerating factor restrains complement activation and delays progression of murine cBSA-induced membranous nephropathy.

Kidney360. Decay-accelerating factor expression modulates the severity of experimental focal segmental glomerulosclerosis.

Kidney International Reports. Increased Complement Gene Expression in Circulating B Cells From Kidney Transplant Recipients With Chronic Antibody-Mediated Rejection.

2022

JCI Insight. Linking erythropoietin to Treg-dependent allograft survival through myeloid cells.

Immunity. Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation.

2021

Atherosclerosis. Single cell analyses to understand the immune continuum in atherosclerosis.

2023

Frontiers in Immunology. Influenza breakthrough infection in vaccinated mice is characterized by non-pathological lung eosinophilia.

The Lancet Infectious Diseases.  Mpox vaccine and infection-driven human immune signatures: an immunological analysis of an observational study.

Clinical Immunology.  TACI and endogenous APRIL in B cell maturation.

Immunity. Monocytes re-enter the bone marrow during fasting and alter the host response to infection.

Nature. Autoimmunity in Down's syndrome via cytokines, CD4 T cells and CD11c+ B cells.

2022

Immunity. Excessive negative regulation of type I interferon disrupts viral control in individuals with Down syndrome.

iScience. Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1.

Journal of Experimental Medicine. A partial form of inherited human USP18 deficiency underlies infection and inflammation.

2023

Nature Neuroscience. Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes.

2022

Journal of Experimental Medicine. Sleep exerts lasting effects on hematopoietic stem cell function and diversity.

Molecular Neurodegeneration. Transcriptome deregulation of peripheral monocytes and whole blood in GBA-related Parkinson’s disease.

Nature. Brain motor and fear circuits regulate leukocytes during acute stress.