Physiology of T cells

Mechanisms of lesion formation and repair in multiple sclerosis

Cancer Vaccines, Innate Immunity & Immunotherapy

Human immunogenetics

Basic and applied tumor immunology for the development of cancer immunotherapies

Factors that control immunity and tolerance

Macrophage-mediated resolution of inflammation in cardiometabolic disease

Virus host interactions that cause disease in humans

Genetic and immunologic factors associated with Inflammatory Bowel Diseases

Deciphers the molecular determinants of immune recognition, dissects the major contributing factors in cancer development, and predicts responses to cancer immunotherapy.

Understanding the role of the microbiome in immune disorders

Investigates human B cell responses to vaccines against emerging pathogens

Human immunodeficiency diseases and immuno-reconstitution

Biology of normal B cells & their cancerous counterparts

Devoted to drug discovery and delivery for the treatment of genetic disorders, infectious diseases, and cancers

γδ intraepithelial lymphocyte biology in Inflammatory Bowel Disease

Develops and applies tools to understand interactions between diet, gut microbes and human health

Immunobiology of allogeneic hematopoietic stem cell transplantation

Monoclonal antibodies inhibiting proteolytic cleavage of surface proteins

Identification of molecular and cellular mechanisms using Multi-OMICs

Transcriptional and post-transcriptional regulation mechanisms to identify therapeutic opportunities in oncology

Identifying new genes regulating arthritis severity and joint damage

Computational cancer genomics

Atopic dermatitis, alopecia areata, and other inflammatory skin diseases

Interactions between TAMs with tumor cells and T-cells

Human NK cells and T cells and their roles in cancer

Evolving genome editing tools into next-generation gene therapies

T cell differentiation in cancer and chronic infection

Allergic and chronic pruritic disorders

Mechanisms of B cell memory for allergic responses

How dysregulation in the immune system contributes to development of disease

Mechanisms of liver cancer initiation and liver cancer maintenance

Understand the evolution of cancer and pathogens

Biology of mucosal dendritic cells

Innate immune cells to develop novel therapies against cancer and inflammatory diseases

How genetic and epigenetic variation leads to aberrant gene expression in B cell malignancies

Growth factor signaling regulation in normal and tumor cells

Molecular mechanisms of neurodegenerative disorders

Dissecting the interplay between the immune system and tumor and host genome in the context of DNA repair deficiencies

Epigenetic basis of neurodegenerative and psychiatric disorders

Investigates human B cell responses to vaccines against emerging pathogens

Innate immunity and inflammation in cardiovascular disease

Gut-derived bacteria that regulate immune function of astrocytes and microglia

Uses single cell, spatial, and high-throughput genomic assays to build data-driven, predictive models of lung cancer and respiratory diseases

Immunogenicity of Transposable elements

Gene regulatory mechanisms in development and diseases

Zamarin Laboratory

Oncolytic viruses, T cell immunotherapy, tumor-immune system interactions