Meetings

Faculty within the Center for Molecular Integrative Neuroresilience at the Icahn School of Medicine at Mount Sinai present topics related to the Center’s research at medical and scientific meetings in the United States and around the world.

Second Annual Symposium

The Center for Molecular Integrative Neuroresilience held its second annual symposium on June 6th, 2017 at the New York Academy of Medicine. Project and Core leaders presented data from Year 2 activities of the Center. Topics included stress-induced psychological and cognitive impairment, mechanisms of neuroresilience and proteostasis, characterization of natural compounds for therapeutic and preventive interventions, and the role of the microbiome in promoting therapeutic efficacy, among others. There were over 60 people in attendance including medical and graduate students, postdoctoral fellows, faculty, and clinicians.

First Annual Symposium

The Center for Molecular Integrative Neuroresilience held its first annual symposium on June 15, 2016 at the New York Academy of Medicine. Project and Core leaders presented data from Year 1 activities of the Center. Topics included stress-induced psychological and cognitive impairment, mechanisms of neuroresilience and proteostasis, characterization of natural compounds for therapeutic and preventive interventions, and role of the microbiome in promoting therapeutic efficacy, among others. There were over 60 people in attendance including medical and graduate students, postdoctoral fellows, faculty, and clinicians.

Recent and Upcoming Meetings

  • D. Zhao, B. Yuan, E. Carry, G.M. Pasinetti, L. Ho, J. Faith, J. Wang, J.E. Simon and Q.L. Wu. 2017. Development and validation of a UPLC-triple quadruple-MS/MS method for the determination of phenolic acid metabolites in biological samples. NIH Centers for Advancing Research on Botanicals and Other Natural Products (CARBON) Program Annual Meeting, May 18-19, 2017, Chicago, USA.

  • M. Docampo, A. Olubu, X. Wang, G.M. Pasinetti, and R. Dixon. Glucuronidation of flavonoids: a comparison of synthetic and bioengineering approaches. NIH Centers for Advancing Research on Botanicals and Other Natural Products (CARBON) Program Annual Meeting, May 18-19, 2017, Chicago, USA.

  • Wang J, Pasinetti GM. Attenuation of peripheral inflammatory cascades in the treatment of mood disorder. Neuroimmunology 2016, Atlanta, GA, 2016.

  • Wang J, Hodes G, Zhang HX, Esteban-Fernandez A, Ho L, HanMH, Russo S, Pasinetti GM. Targeting inflammation and synaptic plasticity promotes resilience against stress disorder and depression. Annual Meeting at Experimental Biology, Chicago, IL, 2017.

  • Wang J, Pasinetti GM.Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress disorder and depression. Annual Meeting at American Neurology Association, San Diego, CA, 2017.

  • Russo S. Prophylactic interventions to promote resilience against stress-induced depression. Current Topics in Integrative Molecular Neuroresilience Symposium. International Society for Neurochemistry, France, 2017.

  • Wang J, Pasinetti GM. Select polyphenol and/or phenolic acid metabolites promote psychological resilience to stress through attenuation of peripheral inflammatory responses. Miami 2016 Winter Symposium: Inflammation, Miami, FL, 2016.

  • Pasinetti GM. Dietary Botanicals in the Preservation of Cognitive and Psychological Resilience. Integrative Medicine and Health, Las Vegas, NV 2016.

  • Wang J, Pasinetti GM. Novel Prophylactic and therapeutic interventions for stress-induced depression. Neurological Disorders Summit, Baltimore, MD, 2016.

  • Russo S. Banbury Meeting—Can we make animal models of human mental illness? A critical review. Can we model aspects of personality disorders in mice? Cold Spring Harbor, NY 2016. 

  • Russo S. NIAAA Seminar Series. Neuroimmune mechanisms of depression.  Rockville, MD 2016. 

  • Pasinetti GM. Dietary Botanicals in the Preservation of Cognitive and Psychological Resilience. Integrative Medicine and Health, Las Vegas, NV 2016.

  • Pasinetti GM. Novel Application of Brain-Targeting Polyphenol Compounds in Promoting  Resilience Against Sleep Deprivation-Induced Cognitive Dysfunction. American Neurology Association Annual Meeting, Baltimore, MD, 2016.

  • Smith C, Frolinger T, Pasinetti GM. Optogenetic analysis of polyphenol-induced resilience against sleep deprivation-associated cognitive deficits. Society for Neuroscience, San Diego, CA, 2016.

  • Frolinger T, Sharma A, Brathwaite J, Wang J, Pasinetti GM. Altered neuroticism-associated gene expression in mouse model of sleep deprivation induced cognitive impairment. World Congress of Neurology, Kyoto, Japan, 2017.

  • Pasinetti GM. Research of Natural Compounds: The Crossroads between Promotion of Health and Prevention of Age-Related Neurodegeneration with Polyphenols to Avoid the Catastrophic Cliff of Neuronal Failure. National Health Products Research Symposium 2016, Charlottetown, Canada, 2016.

  • Pasinetti GM. Characterization of Novel Bioavailable Bioactive Polyphenolic Compounds for Pharmacological Preservation of Blood Brain Barrier Function in Alzheimer’s Disease. Alzheimer’s Association International Conference, Toronto, Canada, 2016.

  • Pasinetti GM. The Crossroads between Promotion of Health and Prevention of Age-Related Neurodegeneration with Polyphenols. Alternative Medicine 2016, Beijing, China, 2016.

  • Frolinger T, Sharma A, Brathwaite J, Wang J, Pasinetti GM, Wang J, Frolinger T, Smith C. Association of Neuroticism Gene Expression as a Risk Factor of Cognitive Deterioration in Models of cognitive deterioration. Alzheimer’s Association International Conference, London, UK, 2017.

  • Ho L and Pasinetti GM. The role of intestinal microbiota in the characterization of natural drug pharmaceutical preparations in the treatment of major depressive disorder. World Congress Expo on Pharmaceutics and Drug Delivery Systems, Dubai, 2016.

  • Ho L, Faith J, Pasinetti GM.Role of Intestinal Microbiota in the Preservation of Psychological and Cognitive Resilience.Microbiome & Mice - Advancing Microbiome Research Symposium, New York, NY 2016.

  • Llewellyn, SR, Britton GJ, Contijoch E, Mortha A, Merad M, Faith JJ. The effects of diet and the microbiota in determining host health. Mucosal Immunology Course & Symposium. Toronto, Canada, July 2016.

  • Ho L, Ono K, Tiano S, Faith J, Valcarcel B, Pasinetti GM. Protective roles of intestinal microbiota in Alzheimer’s disease through mechanisms involving short chain fatty acids. American Neurological Association Annual Meeting, Baltimore, USA, October 2016.

  • Ho L, Faith J, Sims S, Pasinetti GM. The Role of Intestinal Microbiota in the Characterization of Novel Natural Drug Compounds in the Treatment of Major Depressive Disorder. American Neurology Association Annual Meeting, Baltimore, MD, October 2016.

  • Ho L, Ono K, Faith J, PasinettiGM.  Role of gut microbiota-derived phenolic acids and short chain fatty acids in attenuation of protein misfolding in neurodegeneration. Experimental Biology Annual Meeting, Chicago, USA, April 2017.

  • Pasinetti GM. Protective Roles of Intestinal Microbiota in Alzheimer’s Disease through Mechanisms Involving Short Chain Fatty Acids and Phenolic Acids Alzheimer’s Association International Conference, Toronto, Canada, 2016.

  • Pasinetti GM. Interplay between intestinal microbiota and the brain in the promotion of Neuroresilience in aging by polyphenols. International Conference on Restorative & Alternative Medicine, Chicago, IL, 2016.

  • Pasinetti GM, Ho L, Ono K, Yamasaki T. Role of Microbiota Derived Short Chain Fatty Acids in α-Synuclein Aggregation and Seeding. Innovate Neurology 2017, Sydney Australia, 2017.

Symposia Organized

  • Pasinetti GM. Symposium on “Emerging Impact of GI Microbes on Neuropsychiatric Disorders.” 5th Annual Meeting of the Molecular Psychiatry Association, San Francisco, California, October 30 2017.

  • Pasinetti GM. Symposium on “Role of Microbiome-derived polyphenols in models of depression and anxiety.” Cocoa and Chocolate Association of Japan Symposium, Kyoto, Japan, September 15 2017.

Other Abstracts of Presentations Pertinent to Center Activity

  • Alon Lai, Hironobu Watanabe, Michael Schuchman, Lap Ho, Samuel Cho, Andrew Hecht, Giulio M. Pasinetti, James C. Iatridis. Polyphenol Metabolites Potentially Alleviates Painful Behavior Induced by Annular Injury – An In-vivo Rat Model. Philadelphia Spine Research SocietyMeeting, Philadelphia, PA, 2016.

  • Pasinetti GM. Role of Polyphenols in Promotion of Healthy Brain Aging and Alzheimer’s Disease Preventative Initiatives. Bioactives and Neurodegenerative Diseases, Dubai, 2016.

  • Pasinetti GM. Shared genetic etiology underlying type 2 diabetes and Alzheimer's disease. 9th Global Diabetologists Annual Meeting and Medicare Expo, Dallas, TX, 2016.

  • Pasinetti GM. Novel Role of the Neurospecific SCFFbx2-E3-Ligase in Mechanisms Associated with the Promotion of Synaptic Plasticity through Rescue of cAMP-CREB Signaling Pathway in a Model of Alzheimer’s Disease. Alzheimer’s Association International Conference, Toronto, Canada, 2016.

  • Pasinetti GM. Repurposing Drug for Treatment of Prostate Cancer for Prevention of Dementia in Parkinson’s Disease. Alzheimer’s Association International Conference, Toronto, Canada, 2016.

  • Pasinetti GM. Characterization of polyphenolic compounds in the attenuation in frontotemporal dementia and other tauopathies. Wine Active Compounds International Conference 2017, Beaune, France, 2017.

  • Pasinetti GM. Multiscale Genomic Approach and Big Data Analysis Support a Shared Etiology between Type 2 Diabetes and Alzheimer's Disease. Global Summit on Diabetes and Endocrinology, Dubai, 2017.