Center for Molecular Integrative Neuroresilience

The Center for Molecular Integrative Neuroresilience at the Icahn School of Medicine at Mount Sinai is a National Institutes of Health (NIH) Office of Dietary Supplements (ODS) and National Center for Complementary and Integrative Health (NCCIH)-funded Center for Advancing Research on Botanical and Other Natural Products (CARBON) program. The Center collaborates with the Friedman Brain Institute, and the Departments of Genetics and Genomics Sciences, Neurology, and Psychiatry at Mount Sinai, to understand the mechanism of action of the role of certain botanical dietary supplements, in particular polyphenols, have against stressful events and to clarify the role of the gut microbiome at the genomic level in the promotion of cognitive and psychological resilience.

Researchers look at naturally occurring compounds, which have been recognized for their therapeutic value in medical disorders. Notably, the 2015 Nobel Prize in Medicine specifically recognized developments of bioactive compounds from natural products for disease treatment. Collectively our Center is creating a culture of innovation that emphasizes creativity, disruptive thinking, and interdisciplinary collaboration to understand the mechanisms associated with the promotion of neuroresilience.

Areas of Research

Multidisciplinary joint efforts cover three areas of research: preservation of psychological resilience under chronic stress; promotion of resilience against cognitive decline induced by sleep deprivation; and the role of the gut microbiome in promotion of cognitive and psychological resilience. Learn more about our areas of research

Supporting Cores

Three cores help ensure success of the Center’s research projects through administrative oversight; education and training; bioactivity and mechanistic studies; behavioral phenotyping; and electrophysiological support. Learn more about our supporting cores


The Center organizes educational opportunities and funds pilot projects and grants in the field of molecular integrative neuroresilience. Learn more about education and research opportunities at the Center


Faculty with expertise in neurology, neuroscience, critical care and sleep medicine, clinical immunology, genetics and genomics, and pharmacology and systems therapeutics from the Icahn School of Medicine at Mount Sinai work with faculty from Rutgers University and the University of North Texas to conduct the Center’s research. Learn more about our researchers