General Internal Medicine Research Program

The Division of General Internal Medicine faculty has over 50 active research studies across a broad range of patient and population-based research activities spanning the hospital, ambulatory care, and home care settings. Methodological areas of focus include: clinical epidemiology, outcomes research, health services research, quality of care, health disparities, doctor-patient communication, chronic disease management, health beliefs, patient safety, medical errors, prediction rules, evidence-based medicine, medical education, and medical informatics. Specific topics include: asthma, hepatitis C, thromboembolic disease, cardiovascular disease, cerebrovascular disease, COVID-19, diabetes, hypertension, depression, pneumonia, homebound elderly, carotid endarterectomy, tuberculosis, lung cancer, colorectal cancer, women's health, palliative care, geriatrics, and medical education, among others.

Juan P. Wisnivesky, MD, DrPH
Dr. Wisnivesky is Chief of the Division of General Internal Medicine at the Icahn School of Medicine at Mount Sinai. He is a clinical epidemiologist whose research focuses on asthma, lung cancer, COVID-19, and outcomes research. He has led studies assessing the self-management, treatment, and outcomes for patients with asthma, COPD, multimorbidity, COVID-19 and lung cancer. He is also an expert in secondary analyses of national databases with a particular focus on cancer research in the elderly. Since 2020, Dr. Wisnivesky has lead both the Mount Sinai Health System Post-COVID-19 Registry and is one of the PIs of the adult cohort for the NIH’s RECOVER Initiative at Mount Sinai.

Alex Federman, MD, MPH
Dr. Federman is a Professor of Medicine and Geriatrics and Palliative Medicine. He is Director of Research for the Division of General Internal Medicine, a primary care physician and health services researcher. He is also a current Health and Aging Policy Fellow in the Senate Special Committee on Aging. His research addresses self-management behaviors among older adults with complex chronic illnesses. This work encompasses themes such as health literacy, cognitive function, and illness and medication beliefs. His research also involves evaluation of innovative models of healthcare delivery in ambulatory and acute care settings.

Jacqueline Becker, PhD
Dr. Becker is a licensed clinical neuropsychologist and mentored researcher who completed her doctoral training at Fordham University, her residency at Harvard Medical School/Massachusetts General Hospital, and a post-doctoral fellowship in the Department of Neurology at Northwell Health. Her research interests focus on the bidirectional impact of cognitive impairment in chronic medical diseases, particularly in underserved minority populations.

Louisa Holaday, MD, MHS
Dr. Holaday is a primary care physician and health services researcher whose work focuses on the effects of neighborhood and community on health, including the spillover effects of mass incarceration. She is also interested in increasing diversity in the physician workforce. She completed medical school at the University of Michigan, where she did her undergraduate work with a focus in Metropolitan Studies. She was born and raised in New York City, and returned home for residency in Primary Care/Social Internal Medicine at Montefiore, where she was Chief Resident. Following residency, she did a research fellowship at the National Clinician Scholars Program at Yale University.

Minal Kale, MD, MPH
Dr. Kale is an Associate Professor of Medicine, a practicing internist, and clinical researcher. Her research aims to understand how to optimize lung cancer screening, examining key factors such as the impact of chronic diseases on screening benefits and harms and understanding patient preferences regarding lung cancer screening communication. She is supported by a Research Scholar Grant from the American Cancer Society and an R01 from the National Institutes of Minority Health and Health Disparities.

Joseph Kannry, MD
Dr. Kannry is a board certified clinical informaticist and a graduate of the Yale Center for Medical Informatics, a National Library of Medicine training program in informatics. His research has focused on clinical decision support, usability, integration of genomic clinical decision support into the electronic health record, leveraging electronic health records to support research, patient engagement with personal health records, and operationalizing informatics.

Chung Yin Kong, PhD
Dr. Chung Yin Kong is a health outcomes researcher focusing on cancer prevention, screening, and treatment. His principal research area resides in the use of simulation modeling to integrate disparate data with the goal of informing health policies. He completed his Ph.D. in engineering at the University of Massachusetts at Amherst and began his academic career as an instructor of radiology at Harvard Medical School.

Dr. Kong is an MPI (U01CA253858 and U01CA265739) for both the Lung and Uterine Groups of the National Cancer Institute's (NCI) Cancer Intervention and Surveillance Modeling Network (CISNET).

Jenny Lin, MD, MPH
Dr. Lin is a Professor in the Department of Medicine at the Icahn School of Medicine at Mount Sinai in New York. She received her MD from Harvard Medical School and completed an internal medicine residency in the primary care track at Beth Israel Deaconess Hospital in Boston. She has been a clinician-educator at the residency and medical school levels and is currently a clinician-investigator with funding from the American Cancer Society and National Cancer Institute. Her research examines how health beliefs affect the management of comorbid illnesses, particularly diabetes and hypertension, in cancer survivors. She continues to teach at the medical school and in the internal medicine residency program.

Melissa Mazor, PhD, MS, RN
Dr. Mazor is a health services researcher and community-engaged nurse scientist. She has a strong interest in developing interventions that enhance equity in supportive care access and delivery for patients with advanced cancer. She is trained as an advanced practice oncology nurse and completed clinical and research training in oncology nursing and symptom management at the University of California, San Francisco and research fellowships at New York University and the Icahn School of Medicine at Mount Sinai. She is currently funded by the National Cancer Institute and Rita and Alex Hillman foundations to study the development and evaluation of a supportive care intervention for Black and Latinx women with breast cancer and their family caregivers.

Keith Sigel, MD, MPH
Dr. Sigel completed medical school and received a Masters Degree in Public Health at the University of North Carolina and a PhD in clinical research at the Icahn School of Medicine at Mount Sinai. He then completed residency training in internal medicine at Mount Sinai, followed by fellowships in general internal medicine and infectious diseases. His research focus is assessing cancer risk and optimizing cancer treatment in HIV infected persons. He is the principal investigator of a National Cancer Instituted-funded trial of anal cancer screening in women.

Jeffrey Weiss, PhD, MS
Dr. Weiss is a licensed clinical psychologist who has worked for over 30 years in the United States and Europe providing direct care to persons with HIV and hepatitis C virus infection and conducting research on how behavioral interventions can improve their quality and length of life. He developed the Psychosocial Readiness Assessment and Preparation for hepatitis C (PrepC; prepc.org) and co-developed the HepCure toolkit (hepcure.org).

Faculty in the Division of General Internal Medicine (DGIM) conducting research studies are well-supported by the Division’s exceptional Research Program. The Research Program provides investigators and faculty interested in research collaborations with grant submission/management support, guidance on study implementation, audit preparation, and statistical analysis. Our team of over 65 trained research staff (6 data analyst, 11 project managers, and approximately 50 research coordinators) are knowledgeable in research methods and data collection. Approximately 25% of the staff is bilingual in Spanish, affording an underserved population of patients the opportunity to participate in research and ensuring our projects report on outcomes for the diverse New York City communities we serve. Data analysts and project managers are available for consultation to Division faculty by contacting the Research Program Director (Melissa Martynenko, melissa.martynenko@mountsinai.org).

The Division has four principal areas of research: cancer (epidemiology, screening, treatment, outcomes, comparative effectiveness); chronic illness self-management and behaviors (including observational and intervention studies); COVID-19 outcomes and treatments; and aging and cognition. A common thread running through these focus areas is disparities in care and outcomes for marginalized populations and identification, development and testing of strategies to address them.

Investigators in our Division collaborate extensively with one another and across departments and institutes at Mount Sinai. Our emphasis on multidisciplinary team science has enabled us to double the Division’s grants portfolio over the last 8 years.

distribution of research topics pie chart