HIV-Related Kidney Disease Clinical Studies

Christina Wyatt, MD is a clinical investigator with an interest in HIV-related kidney disease. She is currently supported by an NIH R01 to study subclinical kidney and bone injury in HIV-negative individuals who are taking antiretroviral pre-exposure prophylaxis to reduce the risk of HIV infection. She is a co-investigator on an R01 investigating the impact of statin therapy on kidney disease risk in HIV-positive individuals. She also serves as the director of the clinical core of a translational program project grant (P01) investigating the pathogenesis of HIV-associated nephropathy, and as a co-investigator on a translational R01 evaluating the kidney as a potential reservoir for HIV. 

Grant Title: Incidence and Implications of Subclinical Kidney Injury with Tenofovir-based PrEP

Funding Agency: NIH/ NIDDK

Wyatt CM, Morgello S, Katz-Malamed R, Wei C, Klotman ME, Klotman PE, D’Agati VD. Acquired immunodeficiency syndrome and the spectrum of kidney disease in the era of antiretroviral therapy. Kidney Int 75:428-434, 2009.  

Wyatt CM, Hoover DR, Shi Q, et al. Microalbuminuria is associated with all-cause and AIDS mortality in women with HIV infection. JAIDS, 55:73-77, 2010.

Wyatt CM, Shi Q, Novak JE, et al. Prevalence of kidney disease in HIV-infected and uninfected Rwandan women. PLoS ONE 6(3):e18352, 2011.

Medapalli R, Parikh CR, Gordon K, Brown ST, Butt AA, Gibert CL, Rimland D, Rodriguez-Barradas MC, Chang CH, Justice AC, He JC, Wyatt CM. Comorbid diabetes and the risk of progressive chronic kidney disease in HIV-infected adults: Data from the Veterans Aging Cohort Study. JAIDS 60:393-399, 2012.

Mocroft A, Neuhaus J, Peters L, Ryom L, Bickel M, Grint D, Koirala J, Szymczak A, Lundgren L, Ross MJ, Wyatt CM. Hepatitis B and C co-infection are independent predictors of progressive kidney disease in HIV-positive, antiretroviral-treated adults. PLoS ONE 7:e40245, 2012.

Inker LA, Wyatt C, Creamer R, Hellinger J, Hotta M, Leppo M, Levey A, Okparavero A, Graham H, Savage K, Schmid CH, Tighiouart H, Wallach F, Krishnasami Z. Performance of creatinine and cystatin C GFR estimating equations in an HIV-positive population on antiretrovirals. JAIDS 61:302-309, 2012.

Estrella MM, Wyatt CM, Pearce CL, Li M, Shlipak MG, Aouizerat BE, Gustafson D, Cohen MH, Gange SJ, Kao WHL*, Parekh RS*. Host APOL1 genotype is independently associated with proteinuria in HIV infection. Kidney Int 84(4):834-40, 2013

Wyatt CM, Kitch D, Gupta SK, Tierney C, Daar ES, Sax PE, Ha B, Melbourne K, Grace A McComsey GA, for the AIDS Clinical Trials Group Study A5224s Team. Changes in Proteinuria and Albuminuria with Initiation of Antiretroviral Therapy: Data from a Randomized Trial Comparing Tenofovir Disoproxil Fumarate/ Emtricitabine versus Abacavir/ Lamivudine. JAIDS 67: 36-44, 2014.

Lucas GM, Ross MJ, Stock PG, Shlipak MG, Wyatt CM, Gupta SK, Atta MG, Wools-Kaloustian KK, Pham PA, Bruggeman LA, Lennox JL, Ray PE, Kalayjian RC. Executive Summary: Clinical Practice Guideline for the Management of Chronic Kidney Disease in Patients Infected With HIV: 2014 Update by the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis. 59(9):1203-1207, 2014.

Mugwanya KK, Wyatt CM, Celum C, Donnell D, Mugo NR, Tappero J, Kiarie J, Ronald A, and Baeten JM for the Partners PrEP Study Team. Changes in glomerular kidney function among HIV-1 uninfected men and women receiving emtricitabine/ tenofovir disoproxil fumarate pre-exposure prophylaxis: a randomize placebo-controlled trial. JAMA Intern Med 175: 246-254, 2015.

Achhra AC, Mocroft A, Ross MJ, Ryom L, Lucas GM, Furrer H, Neuhaus J, Somboonwit C, Kelly M, Gatell JM, and Wyatt CM for the INSIGHT START Study Group. Kidney disease in antiretroviral-naïve HIV-positive adults with HIV CD4: Prevalence and predictors of kidney disease at enrolment in INSIGHT Strategic Timing of Antiretroviral Treatment Study. HIV Medicine 16 Suppl: 55-63, 2015.

Nadkarni GN, Patel AA, Yacoub RC, Benjo A, Konstantinidis I, Annapureddy N, Kumar Agarwal S, Simoes P, Menon MC, Wyatt CM. The burden of dialysis-requiring acute kidney injury among hospitalized adults with HIV infection: A Nationwide Inpatient Sample Analysis. JAIDS 29: 1061-1066, 2015.

Mugwanya KK, Wyatt C, Celum C, Donnell D, Kiarie J, Ronald A, Baeten J. Reversibility of glomerular renal function decline in HIV-uninfected men and women discontinuing emtricitabine-tenofovir disoproxil fumarate pre-exposure prophylaxis. JAIDS 71 (4): 374-380, 2016.

Mugwanya KK, Baeten JM, Celum C, DonnellD, Nickolas TL, MugoN, Branch AD, Tappero J, James KiarieJ, Ronald A, Yin M, Wyatt C. Partners PrEP Study Team. Low risk of Proximal Tubular Dysfunction Associated with EmtricitabineË—Tenofovir Disoproxil Fumarate Pre-Exposure Prophylaxis in Mend and Women. J Infect Dis, accepted.

Weiss JJ, Konstantinidis I, Boueilh A, Fierer DS, Gardenier D, Barber MG, Kang T, Kress A, Ericson K, Lira MC, Yostos MP, Bogner HR, Wisniveski JP, Wyatt CM. Illness perceptions, medication beliefs, and adherence to antiretrovirals and medications for comorbidities in adults with HIV infection and hypertension or chronic kidney disease. JAIDS, accepted.

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