Pediatric Research

The Department of Pediatrics at the Icahn School of Medicine at Mount Sinai has a long and distinguished tradition of excellence in clinical, translational, and basic research. Our research aims to better understand, treat, and prevent childhood diseases. Our Department is well-funded––both federally and non-federally. Our research portfolio continues to demonstrate in our extramural funding portfolio that exceeds $23 million.

Our Department’s research interests include:

  • Molecular genetics of congenital heart disease
  • Molecular physiology and regulation of ion transport in developing kidneys
  • Immune-pathogenic mechanisms and treatment of food allergy and asthma
  • Genetics and genomics of asthma and allergic diseases
  • Regulation of chromatin structure and function during gene transcription
  • Molecular mechanisms underlying congenital disorders of glycosylation
  • Early life predictors of developmental diseases
  • Traumatic stress reactions and nonadherence to medical regimens
  • HPV persistence and risk factors among adolescent girls
  • Genetics and immune responses in clinical presentations, treatment responses, and prognosis in inflammatory bowel disease (IBD)
  • Biomarkers and patient-related outcomes in juvenile idiopathic arthritis
  • Interventions to help teens at risk for type 2 diabetes
  • Communication between families of critically ill neonates and providers
  • Molecular genetics of childhood brain cancer
  • Neuroendocrine regulation of energy balance and cognitive functioning, including genetic, environmental, and behavioral determinants of metabolic health in the general population and in patients with rare genetic disorders associated with obesity and Type 2 diabetes
  • Environmental exposures, including stress, nutritional exposures, and environmental toxicants, during critical periods of development, influence childhood asthma risk

Mindich Child Health and Development Institute

The Mindich Child Health and Development Institute (MCHDI) is a translational research enterprise, which seeks to improve the knowledge base and therapies for pediatric diseases. Our research focuses on asthma and allergies, obesity and diabetes, cardiovascular disease, neurodevelopmental disorders, and more.

MCHDI provides an intellectually rich and supportive environment for fostering collaborative scientific investigation and Mount Sinai’s “bench to bedside” philosophy, as well as training the next generation of scientific leaders in child health research.