Mount Sinai Genomic Health Initiative
Expertise in genomics research and genomic medicine is embedded across Mount Sinai’s departments, institutes, and clinical programs, enabling collaboration that accelerates both discovery and real-world impact. Launched in 2018, the Mount Sinai Genomic Health Initiative coordinates and connects these efforts across research, education, and clinical implementation, bringing together clinicians, scientists, data scientists, and educators to advance genomic medicine at scale.
By combining genomic technologies with biobank-scale and EHR-linked data, and increasingly with AI-enabled analytic approaches, the Initiative supports the generation of actionable insights that improve diagnosis, risk assessment, treatment selection, and precision medicine. Mount Sinai faculty are focused not only on discovery but also on responsible integration of genomics into routine care, with attention to outcomes, workforce development, and patient and community partnership.
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Department/Institutes |
Description |
Lead |
| Department of Genetics and Genomic Sciences
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Understanding genetic variation as it relates to health and disease. Caring for patients with genetic diseases.
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Pioneering patient-centered AI to improve outcomes through innovation, real-time data insights, partnerships, and ethical, responsible clinical implementation. |
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| Charles Bronfman Institute for Personalized Medicine
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Biobanking to revolutionize medicine and health care
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Genomic research on neurological and psychiatric disorders
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Developing new RNA and DNA based therapies
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Transforming genomics into new paradigms for preventive health
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| Mindich Child Health and Development Institute |
Understanding effects of genes and environment on children’s health
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| Mount Sinai Heart |
Invigorating the science of cardiovascular medicine and leading cardiology care, cardiac surgery, and advanced research |
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| Tisch Cancer Institute |
Advancing clinical breakthroughs to help prevent and eradicate cancer
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Divisions/Centers |
Description |
Lead |
| Division of Genomic Medicine (Department of Medicine)
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Integrating genomic information into routine primary care
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| Division of Medical Genetics and Genomics (Department of Genetics and Genomic Sciences)
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Genetic screening, diagnosis and management of adult and pediatric patients with known or suspected genetic disorder
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Division of Neurogenetics (Department of Neurology)
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Improving the diagnosis and treatment of patients with neurological manifestations from rare genetic diseases
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Center for Advanced Genomic Technology (Department of Genetics and Genomic Sciences) |
Generating innovative omics technology to enable highly resolved scientific and translational discoveries
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Promoting precision medicine across neuropsychiatric diseases
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Center for Inherited Cardiovascular Diseases (Mount Sinai Heart)
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Implementing and advancing genetic and genomic approaches to improve diagnosis, treatment and prevention of cardiovascular disease |
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Center for Genomic AI and Microbiome Medicine |
TBD |
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| Center for Transformative Disease Modeling (Department of Genetics and Genomic Sciences) |
Developing predictive models of diseases towards precision medicine
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Center for Translational Genomics (Institute for Genomic Health)
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Improving the reliability, uptake, and integration of polygenic risk scores (PRS) in clinical practice.
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Center for Undiagnosed Diseases (Mindich Child Health and Development Institute) |
Using advanced technologies to diagnose complex, undiagnosed diseases and advance understanding of human health. |
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Ronald M. Loeb Center for Alzheimer’s Disease (Department of Genetics and Genomic Sciences) |
Advancing the diagnosis, prevention, and treatment of Alzheimer's disease using genomics
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| Seaver Autism Center (Department of Psychiatry) |
Bringing precision medicine to autism, identifying and studying autism genes both preclinically and clinically |
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Resources/Programs |
Description |
Lead |
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Providing access to state-of-the-art bioinformatic analysis and training |
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A data commons increasing the power, pace, and relevance of our research |
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A biobank enabling genetic studies on collections of research specimens linked with medical information |
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High performance computational and data ecosystem to accelerate scientific discovery |
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Screens biobank participants’ DNA for actionable cancer and heart disease risks, returning results and connecting individuals to preventive care and support. |
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Education |
Description |
Lead |
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Two-year medical genetics residency offering comprehensive clinical, laboratory, and research training across diverse genetic specialties. |
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Four-Year Internal Medicine/Medical Genetics Residency (MD Program) |
Four-year integrated residency combining internal medicine and medical genetics to train clinical and research leaders in genomic innovation and care. |
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Four-Year Pediatrics/Medical Genetics Residency (MD Program) |
Four-year combined Pediatrics and Medical Genetics residency integrating balanced clinical training, specialized rotations, and advanced genetics coursework. |
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Genetics and Genomic Sciences Multidisciplinary Training Area (PhD in Biomedical Sciences) |
Trains future leaders in genetics and data science to advance disease detection, prediction, and treatment through cutting-edge research and technology. |
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Accredited genetic counseling program training compassionate leaders through rigorous coursework and immersive clinical rotations across diverse genomic specialties. |
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Genetics and Genomics Concentration (MS in Biomedical Sciences) |
Trains future leaders in genetics and data science, offering elective concentrations and thesis specialization in disease detection and precision medicine. |