Precision Immunology Institute at Icahn School of Medicine at Mount Sinai (PrIISM)

Publications

Recent Featured Publications

2020

CELL

Mapping systemic inflammation and antibody responses in multisystem inflammatory syndrome in children (MIS-C)

2020-09

Gruber, et al.

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IMMUNITY

Complex autoinflammatory syndrome unveils fundamental principles of JAK1 kinase transcriptional and biochemical function

2020-08

Gruber, et al.

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NATURE MEDICINE

An inflammatory cytokine signature helps predict COVID-19 severity and death

2020-08

Del Valle, et al.

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SCIENCE IMMUNOLOGY

Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells

2020-07

Grasset, et al.

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NATURE MEDICINE

Sampling the host response to SARS-CoV-2 in hospitals under siege

2020-07

Charney, et al.

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IMMUNITY

Immunology of COVID-19: Current state of the science

2020-06

Vabret, et al.

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NATURE

A conserved dendritic-cell regulatory program limits antitumour immunity

2020-03

Maier, et al.

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CELL HOST & MICROBE

Fecal IgA levels are determined by strain-level differences in Bacteroides ovatus and are modifiable by gut microbiota manipulation

2020-03

Yang, et al.

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THE NEW ENGLAND JOURNAL OF MEDICINE

JAK inhibitor therapy in a child with inherited USP18 deficiency

2020-01

Alsohime, et al.

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2019

CANCER DISCOVERY

Antitumor T-cell homeostatic activation is uncoupled from homeostatic inhibition by checkpoint blockade

2019-11

Marshall, et al.

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PLOS PATHOGENS

Aging boosts antiviral CD8+T cell memory through improved engagement of diversified recall response determinants

2019-11

Davenport, et al.

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NATURE MEDICINE

Single-cell immune landscape of human atherosclerotic plaques

2019-10

Fernandez, et al.

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NATURE COMMUNICATIONS

Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23

2019-10

Chen, et al.

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CELL

Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy

2019-09

Martin, et al.

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CANCER DISCOVERY

Immune checkpoint blockade enhances shared neoantigen-induced T-cell immunity directed against mutated calreticulin in myeloproliferative neoplasms

2019-09

Bozkus, et al.

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CELL

Dietary intake regulates the circulating inflammatory monocyte pool

2019-08

Jordan, et al.

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CANCER DISCOVERY

b-catenin activation promotes immune escape and resistance to anti-PD-1 therapy in hepatocellular carcinoma

2019-08

de Galarreta, et al.

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NATURE MEDICINE

Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination

2019-04

Hammerich, et al.

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IMMUNITY

Microbiotas from humans with inflammatory bowel disease alter the balance of gut Th17 and RORgt+ regulatory T cells and exacerbate colitis in mice

2019-01

Britton, et al.

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2020

Pediatric Allergy and Immunology. IgE and IgG4 binding to lentil epitopes in children with red and green lentil allergy.

Allergy. Ovomucoid epitope-specific repertoire of IgE, IgG4, IgG1, IgA1, and IgD antibodies in egg-allergic children.

The Journal of Allergy and Clinical Immunology. A 5-year summary of real-life dietary egg consumption after completion of a 4-year egg powder oral immunotherapy (eOIT) protocol.

The Journal of Allergy and Clinical Immunology. Induction of sustained unresponsiveness after egg oral immunotherapy compared to baked egg therapy in children with egg allergy.

The New England Journal of Medicine. Hereditary angioedema.  

The Journal of Allergy and Clinical Immunology. Long-term, open-label extension study of the efficacy and safety of epicutaneous immunotherapy for peanut allergy in children: PEOPLE 3-year results.

Allergy. Demonstration of distinct pathways of mast cell-dependent inhibition of Treg generation using murine bone marrow-derived mast cells.

The Journal of Allergy and Clinical Immunology. Tailored management of allergic diseases by age: one size does not fit all.

2019

The Journal of Allergy and Clinical Immunology: In Practice. Diagnosing peanut allergy with fewer oral food challenges.

Allergy. Clinical factors associated with peanut allergy in a high-risk infant cohort.

The Journal of Allergy and Clinical Immunology. Multicenter, randomized, double-blind, placebo-controlled clinical trial of vital wheat gluten oral immunotherapy.

The Journal of Allergy and Clinical Immunology. Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope-specific antibody binding profiles.

Allergy. A new Luminex-based peptide assay to identify reactivity to baked, fermented, and whole milk.

Pediatric Allergy and Immunology. IgE and IgG4 binding to lentil epitopes in children with red and green lentil allergy.

Immunity. The secret life of IgE-producing cells.

The Journal of Allergy and Clinical Immunology. A 5-year summary of real-life dietary egg consumption after completion of a 4-year egg powder oral immunotherapy (eOIT) protocol.

2020

Journal of Hepatology. Novel patient-derived preclinical models of liver cancer.

Frontiers in Immunology. Computational prediction and validation of tumor-associated neoantigens.

Cell Death & Disease. Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL).

Clinical Cancer Research. Mouse models of oncoimmunology in hepatocellular carcinoma.

Cancer Immunology Research. Combined vaccination with NY-ESO-1 protein, poly-ICLC, and montamide improves humoral and cellular immune responses in patients with high-risk melanoma.

Oncotarget. MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21Cip1.

Clinical Advances in Hematology & Oncology. Improving outcomes with checkpoint blockade in non-Hodgkin lymphoma.

2019

Nature Medicine. Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination.

Cancer Discovery. b-catenin activation promotes immune escape and resistance to anti-PD-1 therapy in hepatocellular carcinoma.

Nature Reviews Cancer. Host tissue determinants of tumour immunity.

Cancer Discovery. Immune checkpoint blockade enhances shared neoantigen-induced T-cell immunity directed against mutated calreticulin in myeloproliferative neoplasms.

Gastroenterology. Interleukin 1 beta and matrix metallopeptidase 3 contribute to development of epidermal growth factor receptor-dependent serrated polyps in mouse cecum.

Cancer Discovery. Antitumor T-cell homeostatic activation is uncoupled from homeostatic inhibition by checkpoint blockade.

Clinical Cancer Research. Pathogen molecular pattern receptor agonists: treating cancer by mimicking infection.

Gut. Hepatocellular carcinoma: killing one bird with two stones.

Cancer Immunology Research. Combined vaccination with NY-ESO-1 protein, poly-ICLC, and montanide improves humoral and cellular immune responses in patients with high-risk melanoma.

Journal of Experimental Medicine. Iron overload and liver cancer.

2020

Clinical Gastroenterology and Hepatology. A user’s guide to de-escalating immunomodulator and biologic therapy in inflammatory bowel disease.

Journal of Crohn’s and Colitis. JAK inhibitors safety in ulcerative colitis: practical implications.

Gastroenterology. Deep remission at 1 year prevents progression of early Crohn’s disease.

Clinical Gastroenterology and Hepatology. Stopping mesalamine therapy in patients with Crohn’s disease starting biologic therapy does not increase risk of adverse outcomes.

Inflammatory Bowel Diseases. Association of biomarker cutoffs and endoscopic outcomes in Crohn’s disease: a post hoc analysis from the CALM study.

Alimentary Pharmacology and Therapeutics. Systematic review and meta-analysis: efficacy and safety of early biologic treatment in adult and paediatric patients with Crohn’s disease.

Clinical Gastroenterology and Hepatology. Effect of concomitant therapy with steroids and tumor necrosis factor antagonists for induction of remission in patients with Crohn’s disease: a systematic review and pooled meta-analysis.

Gastroenterology. Serum biomarkers identify patients who will develop inflammatory bowel diseases up to 5 years before diagnosis.

Gastroenterology. New blood marker of endoscopic disease activity – a step forward in treating Crohn’s disease to target?

Gastroenterology. Age is just a number-frailty associates with outcomes of patients with inflammatory bowel disease.

2019

Cell. Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy.

Clinical Gastroenterology and Hepatology. Rapid responses to vedolizumab therapy in biologic-naïve patients with inflammatory bowel diseases.

Elife. Gut microbiota density influences host physiology and is shaped by host and microbial factors.

Gut. Epidemiology and implications of concurrent diagnosis of eosinophilic oesophagitis and IBD based on a prospective population-based analysis.

Gastroenterology. Treating inflammatory bowel disease with diet: a taste test.

Alimentary Pharmacology and Therapeutics. Review article: bacteriophages in gastroenterology – from biology to clinical applications.

Clinical Gastroenterology and Hepatology. A user’s guide to de-escalating immunomodulator and biologic therapy in inflammatory bowel disease.

Clinical Gastroenterology and Hepatology. Patient-reported outcomes and endoscopic appearance of ulcerative colitis: a systematic review and meta-analysis.

Alimentary Pharmacology and Therapeutics. Sex-based differences in the incidence of inflammatory bowel diseases-pooled analysis of population-based studies from the Asia-Pacific region.

Clinical Gastroenterology and Hepatology. Stopping mesalamine therapy in patients with Crohn’s disease starting biologic therapy does not increase risk of adverse outcomes.

2020

American Journal of Transplantation. Peritransplant eculizumab does not prevent delayed graft function in deceased donor kidney transplant recipients: Results of two randomized controlled pilot trials.

Kidney International. Genome-wide non-HLA donor-recipient genetic differences influence renal allograft survival via early allograft fibrosis.

American Journal of Transplantation. Distinct peripheral blood molecular signature emerges with successful tacrolimus withdrawal in kidney transplant recipients.

2019

Therapeutics Advances in Hematology. Biomarkers in acute graft-versus-host disease: new insights.

Journal of the American Society of Nephrology.  A peripheral blood gene expression signature to diagnose subclinical acute rejection.

Blood Advances. The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease.

JCI Insight. Pretransplant transcriptomic signature in peripheral blood predicts early acute rejection.

Best Practice & Research Clinical Haematology. MAGIC biomarkers of acute graft-versus-host disease: Biology and clinical application.

Current Transplantation Reports. Role of complement activation in allograft inflammation.

Clinics in Laboratory Medicine. Complement and transplantation: from new mechanisms to potential biomarkers and novel treatment strategies.

American Journal of Transplantation. C5aR1 regulates migration of suppressive myeloid cells required for costimulatory blockade-induced murine allograft survival.

American Journal of Transplantation. Peritransplant eculizumab does not prevent delayed graft function in deceased donor kidney transplant recipients: results of two randomized controlled pilot trials.

2020

Nature. A conserved dendritic-cell regulatory program limits antitumour immunity.

Biomarkers for Immunotherapy of Cancer. Multiplexed immunohistochemical consecutive staining on single slide (MICSSS): multiplexed chromogenic IHC assay for high-dimensional tissue analysis.

PNAS. High-complexity extracellular barcoding using a viral hemagglutinin.

ImmunoHorizons. HPK1 influences regulatory T cell functions.

Biomedical Chromatography. Development of an ultra-performance liquid chromatography-electrospray ionization-Orbitrap mass spectrometry method for determination of xanthopurpurin in rat plasma and its application to pharmacokinetic study.

Cell Systems. MHCflurry 2.0: improved pan-allele prediction of MHC class I-presented peptides by incorporating antigen processing.

Immunity. Complex autoinflammatory syndrome unveils fundamental principles of JAK1 kinase transcriptional and biochemical function.

2019

Nature Medicine. Single-cell immune landscape of human atherosclerotic plaques.

International Review of Cell and Molecular Biology. Dendritic cell subsets and locations.

Nature Communications. Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23.

Frontiers in Immunology. Non-classical B cell memory of allergic IgE responses.

American Journal of Transplantation. Absence of recipient C3aR1 signaling limits expansion and differentiation of alloreactive CD8+ T cell immunity and prolongs murine cardiac allograft survival.

Applied Immunohistochemistry & Molecular Morphology. Immunohistochemical detection of g/d T lymphocytes in formalin-fixed paraffin-embedded tissues.

PNAS. Type I IFN is siloed in endosomes.

The Journal of Infectious Diseases. Developing broad-spectrum antivirals using porcine and rhesus macaque monkeys.