Precision Immunology Institute at Icahn School of Medicine at Mount Sinai (PrIISM)

Publications

Diagnosing Peanut Allergy with Fewer Oral Food Challenges. Koplin JJ, PMID:30581130

B-cell phenotype and function in infants with egg allergy. Neeland MR, PMID:30589939

Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope-specific antibody binding profiles. Suárez-Fariñas M, PMID:30528770

PDL2(+) CD11b(+) dermal dendritic cells capture topical antigen through hair follicles to prime LAP(+) Tregs. Tordesillas L, PMID:30531969

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. Sicherer SH, PMID:29157945

Food allergy: Update on prevention and tolerance. Du Toit G, PMID:29191680

Treatment for food allergy. Burks AW, PMID:29307409   

Detection of anti-glutamic acid decarboxylase antibodies in immunoglobulin products. Smith TD, PMID:28669890

Mast cell heterogeneity underlies different manifestations of food allergy in mice. Benedé S PMID:29370173

Food allergy. Renz H, PMID:29300005

Early-life gut microbiome and egg allergy. Fazlollahi M, PMID:29318631

A new Luminex-based peptide assay to identify reactivity to baked, fermented, and whole milk. Sackesen C, PMID:30058196

Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations. Vargas-Hernández A, PMID:29111217

Safety and efficacy of epicutaneous immunotherapy for food allergy. Wang J, PMID:29369411

Single-cell profiling of peanut-responsive T cells in patients with peanut allergy reveals heterogeneous effector T(H)2 subsets. Chiang D, PMID:29408715

Phenotypes and endotypes of food allergy: A path to better understanding the pathogenesis and prognosis of food allergy. Baker MG, PMID:29378246

Immune Characterization of Bone Marrow-Derived Models of Mucosal and Connective Tissue Mast Cells. Benedé S, PMID:29676074

Autosomal Dominant Hyper-IgE Syndrome in the USIDNET Registry. Gernez Y, PMID:28939137

Multicenter, randomized, double-blind, placebo-controlled clinical trial of vital wheat gluten oral immunotherapy. Nowak-Węgrzyn A, PMID:30389226

Phenotypic Characterization of Eosinophilic Esophagitis in a Large Multicenter Patient Population from the Consortium for Food Allergy Research. Chehade M, PMID:30075341

Evaluation of Lymphoproliferative Disease and Increased Risk of Lymphoma in Activated Phosphoinositide 3 Kinase Delta Syndrome: A Case Report With Discussion. Pham MN, PMID:30619796

Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies. Maffucci P, PMID:30395541

Regulatory Architecture of the LβT2 Gonadotrope Cell Underlying the Response to Gonadotropin-Releasing Hormone. Ruf-Zamojski F, PMID:29487567

The enigmatic function of IgD: some answers at last. Gutzeit C, PMID:29733429

Disseminated Cutaneous Warts in X-Linked Hyper IgM Syndrome. Ho HE, PMID:29730845

Huntingtin-interacting protein 1 (HIP1) regulates arthritis severity and synovial fibroblast invasiveness by altering PDGFR and Rac1 signalling. Laragione T, PMID:30049830

A novel FAS mutation with variable expressivity in a family with unicentric and idiopathic multicentric Castleman disease. Baker TS, PMID:30404775

Single-cell stabilization method identifies gonadotrope transcriptional dynamics and pituitary cell type heterogeneity. Ruf-Zamojski F, PMID:30357357

Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding Basophils via Galectin-9 and CD44. Shan M, PMID:30291028

TACI Isoforms Regulate Ligand Binding and Receptor Function. Garcia-Carmona Y, PMID:30333819

Primary B-cell immunodeficiencies. Smith T, PMID:30359632

AIRR Community Standardized Representations for Annotated Immune Repertoires. Vander Heiden JA, PMID:30323809

Common variable immune deficiency: Dissection of the variable. Cunningham-Rundles C., PMID:30565247

Aging of Antiviral CD8(+) Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing. Davenport B, PMID:30552164

Epigenetic regulation of brain region-specific microglia clearance activity. Ayata P, PMID:30038282

A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments. Barry KC, PMID:29942093

Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import. Rodriguez-Bravo V, PMID:30100187

EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer. Wang L, PMID:30158554

Radiotherapy induces responses of lung cancer to CTLA-4 blockade. Formenti SC, PMID:30397353

Integrative network analysis identifies novel drivers of pathogenesis and progression in newly diagnosed multiple myeloma. Laganà A, PMID:28642592

RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions. Hogstad B, PMID:29263218

Macrophages orchestrate breast cancer early dissemination and metastasis. Linde N, PMID:29295986

Towards superior dendritic-cell vaccines for cancer therapy. Saxena M, PMID:30116654

Risk stratification of smoldering multiple myeloma: predictive value of free light chains and group-based trajectory modeling. Wu V, PMID:29945937

Advanced Diffusion-weighted Imaging Modeling for Prostate Cancer Characterization: Correlation with Quantitative Histopathologic Tumor Tissue Composition-A Hypothesis-generating Study. Hectors SJ, PMID:29117481

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Meisel M, PMID:29769727

SOX11 augments BCR signaling to drive MCL-like tumor development. Kuo PY, PMID:29615403

Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens. Wroblewska A, PMID:30343902

Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease. Zhao D, PMID:30106382

Human Papilloma Virus Specific Immunogenicity and Dysfunction of CD8(+) T Cells in Head and Neck Cancer. Krishna S, PMID:30154146

Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance. Braza MS, PMID:30413362

Diet Modifies Colonic Microbiota and CD4(+) T-Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-Cell Expression of Interleukin 23. Chen L, PMID:29909020

A whole-blood RNA transcript-based gene signature is associated with the development of CTLA-4 blockade-related diarrhea in patients with advanced melanoma treated with the checkpoint inhibitor tremelimumab. Friedlander P, PMID:30227886

Autologous lymphocyte infusion supports tumor antigen vaccine-induced immunity in autologous stem cell transplant for multiple myeloma. Cohen AD, PMID:30745365

Are random biopsies still useful for the detection of neoplasia in patients with IBD undergoing surveillance colonoscopy with chromoendoscopy?. Moussata D, PMID:28115492

Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn's Disease. Panés J, PMID:29277560

Arctigenin Ameliorates Inflammation by Regulating Accumulation and Functional Activity of MDSCs in Endotoxin Shock. Shi H, PMID:30143931

Effect of tight control management on Crohn's disease (CALM): a multicentre, randomised, controlled phase 3 trial. Colombel JF, PMID:29096949

Specific Bacteria and Metabolites Associated With Response to Fecal Microbiota Transplantation in Patients With Ulcerative Colitis. Paramsothy S, PMID:30529583

Development of an index to define overall disease severity in IBD. Siegel CA, PMID:27780886

Effects of Mongersen (GED-0301) on Endoscopic and Clinical Outcomes in Patients With Active Crohn's Disease. Feagan BG, PMID:28847751

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease. Hui KY, PMID:29321258

Urbanization and the gut microbiota in health and inflammatory bowel disease. Zuo T, PMID:29670252

Identification of Endpoints for Development of Antifibrosis Drugs for Treatment of Crohn's Disease. Danese S, PMID:29601825

Long-term Benefit of Golimumab for Patients with Moderately-to-Severely Active Ulcerative Colitis: Results from the PURSUIT-Maintenance Extension. Reinisch W, PMID:29917070

Adherent-invasive Escherichia coli in inflammatory bowel disease. Palmela C, PMID:29141957

Using Proactive Therapeutic Drug Monitoring of Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease: From an Old Concept to a Future Standard of Care?. Papamichael K, PMID:29432749

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population. Rivas MA, PMID:29795570

Magnetic Resonance Imaging Predicts Histopathological Composition of Ileal Crohn's Disease. Wagner M, PMID:29300851

Microbial-Host Interactions in Inflammatory Bowel Disease, Functional Bowel Disease, Obesity and Obesity-Related Metabolic Disease. Shah SC, PMID:30176219

Efficacy of Ustekinumab for Inducing Endoscopic Healing in Patients With Crohn's Disease. Rutgeerts P, PMID:29909019

Development and Validation of a Scoring System to Predict Outcomes of Vedolizumab Treatment in Patients With Crohn's Disease. Dulai PS, PMID:29857091

Rapid Response to Vedolizumab Therapy in Biologic-Naive Patients With Inflammatory Bowel Diseases. Feagan BG, PMID:29857145

Continuous Clinical Response Is Associated With a Change of Disease Course in Patients With Moderate to Severe Ulcerative Colitis Treated With Golimumab. Reinisch W, PMID:29982631

Location, Location, Location. Hideki Ueno, PMID:30134195

Decreased Fecal Bacterial Diversity and Altered Microbiome in Children Colonized With Clostridium difficile. Chen LA, PMID:30540709

Specific Bacteria and Metabolites Associated With Response to Fecal Microbiota Transplantation in Patients With Ulcerative Colitis. Paramsothy S, PMID:30529583

Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis. Manasson J, PMID:29073348

The role of the gut microbiome in systemic inflammatory disease. Clemente JC, PMID:29311119

Potential Pathways Associated With Exaggerated T Follicular Helper Response in Human Autoimmune Diseases. Horiuchi S, PMID:30061896

Physical Activity, Immune System, and the Microbiome in Cardiovascular Disease. Fernandez DM, PMID:30013482

Interactions Between Diet and the Intestinal Microbiota Alter Intestinal Permeability and Colitis Severity in Mice. Llewellyn SR, PMID:29174952

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Meisel M, PMID:29769727

Stopping 5-aminosalicylates in patients with ulcerative colitis starting biologic therapy does not increase the risk of adverse clinical outcomes: analysis of two nationwide population-based cohorts. Ungaro RC, PMID:30420398

GVHD: biology matters. Ferrara JLM, PMID:30504314

Translating microbiome futures. Taroncher-Oldenburg G, PMID:30412201

Evaluation of the airway microbiome in nontuberculous mycobacteria disease. Sulaiman, PMID:30093571

Disease-modifying therapies alter gut microbial composition in MS. Katz Sand I, PMID:30568995

Microscopic heterogeneity in ulcerative colitis: implications for microscopic measurement of disease activity. Harpaz N, PMID:30723105

Severe Obstructive Sleep Apnea Is Associated with Alterations in the Nasal Microbiome and an Increase in Inflammation. Wu BG, PMID:29969291

Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt(+) Regulatory T Cells and Exacerbate Colitis in Mice. Britton GJ, PMID:30650377

Gut microbiota density influences host physiology and is shaped by host and microbial factors. Contijoch EJ, PMID:30666957

Analysis of Biomarkers Within the Initial 2 Years Posttransplant and 5-Year Kidney Transplant Outcomes: Results From Clinical Trials in Organ Transplantation-17. Faddoul G, PMID:29189482

P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes. D'Addio F, PMID:30010623

C5aR1 regulates migration of suppressive myeloid cells required for costimulatory blockade-induced murine allograft survival. Llaudo I, PMID:30106232

Amphiregulin modifies the Minnesota Acute Graft-versus-Host Disease Risk Score: results from BMT CTN 0302/0802. Holtan SG, PMID:30087106

IL-17A Is Critical for CD8+ T Effector Response in Airway Epithelial Injury After Transplantation. Zhang R, PMID:30211827

Early immune biomarkers and intermediate-term outcomes after heart transplantation: Results of Clinical Trials in Organ Transplantation-18. Stehlik J, PMID:30549425

Absence of recipient C3aR1 signaling limits expansion and differentiation of alloreactive CD8(+) T cell immunity and prolongs murine cardiac allograft survival. Mathern DR, PMID:30565852

Analysis of OPTN/UNOS registry suggests the number of HLA matches and not mismatches is a stronger independent predictor of kidney transplant survival. Yacoub R, PMID:28965746

Impact of preformed T-cell alloreactivity by means of donor-specific and panel of reactive T cells (PRT) ELISPOT in kidney transplantation. Gandolfini I, PMID:30059561

MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD. Major-Monfried H, PMID:29545329

In vivo IL-12/IL-23p40 neutralization blocks Th1/Th17 response after allogeneic hematopoietic cell transplantation. Pidala J, PMID:29242294

T Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell (T(REG)) Generation and T(REG)-Dependent Cardiac Allograft Survival. A Verghese D, PMID:29436411

EBMT-NIH-CIBMTR Task Force position statement on standardized terminology & guidance for graft-versus-host disease assessment. Schoemans HM, PMID:29872128

SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts. Wei C, PMID:30341149

Phase I/II Trial of a Combination of Anti-CD3/CD7 Immunotoxins for Steroid-Refractory Acute Graft-versus-Host Disease. Groth C, PMID:30399420

Microbial metabolite sensor GPR43 controls severity of experimental GVHD. Fujiwara H, PMID:30201970

Effect of Timing and Complement Receptor Antagonism on Intragraft Recruitment and Pro-Tolerogenic Effects of Mesenchymal Stromal Cells in Murine Kidney Transplantation. Casiraghi F, PMID:30801518

The innate immune response to allotransplants: mechanisms and therapeutic potentials. Ochando J, PMID:30804476

Donor Urinary C5a Levels Independently Correlate With Posttransplant Delayed Graft Function. Schröppel B, PMID:30451738

Complement and Transplantation: From New Mechanisms to Potential Biomarkers and Novel Treatment Strategies. Horwitz JK, PMID:30709507

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Mahajan A, PMID:29632382

High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development. Hefti MM, PMID:29634760

Langerhans-Cell Histiocytosis. Allen CE, PMID:30157397

Interpretation of an individual functional genomics experiment guided by massive public data. Lee YS, PMID:30478325

Influenza A Virus Utilizes Low-Affinity, High-Avidity Interactions with the Nuclear Import Machinery To Ensure Infection and Immune Evasion. Tome-Amat J, PMID:30305352

Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells. Ramsuran V, PMID:29302013

CCR8 is expressed by post-positive selection CD4-lineage thymocytes but is dispensable for central tolerance induction. Thyagarajan HM, PMID:30024927

Vagal dysfunction and small intestinal bacterial overgrowth: novel pathways to chronic inflammation in HIV. Robinson-Papp J, PMID:29596112

Tellurium notebooks-An environment for reproducible dynamical modeling in systems biology. Medley JK, PMID:29906293

Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis. Kottyan LC, PMID:29904099

Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses. Barbet G, PMID:29548673

Unnecessary Repeat Enzyme Testing in Acute Pancreatitis: A Teachable Moment. Reisman A, PMID:29532051

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes. Ai R, PMID:29765031

High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue. Konnikova L, PMID:30111863

Neutrophils instruct homeostatic and pathological states in naive tissues. Casanova-Acebes M, PMID:30282719

Ex vivo human HSC expansion requires coordination of cellular reprogramming with mitochondrial remodeling and p53 activation. Papa L, PMID:30348672

BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis. Mandal M, PMID:30250168

Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration. O'Koren EG, PMID:30850344

Blacklisting variants common in private cohorts but not in public databases optimizes human exome analysis. Maffucci P, PMID:30591557

Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation. Kumar A, PMID:29764859

Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity. Balan S, PMID:30110645

Anhedonia as a clinical correlate of inflammation in adolescents across psychiatric conditions. Freed RD, PMID:29843560

miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy. Oh JG, PMID:30355233

Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming. Gomes AM, PMID:30517869

Untangling Genetic Risk for Alzheimer's Disease. Pimenova AA, PMID:28666525

Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice. Wang J, PMID:29396460

MHCflurry: Open-Source Class I MHC Binding Affinity Prediction. O'Donnell TJ, PMID:29960884

Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells. Kirkling ME, PMID:29925006

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. Raj T, PMID:30297968

Disease-modifying therapies alter gut microbial composition in MS. Katz Sand I, PMID:30568995

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism. Kapoor M, PMID:30765688

The cis-Regulatory Atlas of the Mouse Immune System. Yoshida H, PMID:30686579

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Kunkle BW, PMID:30820047

Fumarates target the metabolic-epigenetic interplay of brain-homing T cells in multiple sclerosis. Ntranos A, PMID:30698680

Prioritizing Parkinson's disease genes using population-scale transcriptomic data. Li YI, PMID:30824768

A Transcriptomic Signature of Tertiary Gleason 5 Predicts Worse Clinicopathological Outcome. Martini A, PMID:30825357

Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells. Wang P, PMID:30581122