Our investigators conduct basic science and translational research, often in collaboration with other departments, to study and treat psychiatric disorders.
Akbarian Laboratory of Epigenetic Regulation of the Human Brain
We explore epigenetic regulation of gene expression to identify epigenetic drug targets and novel treatment avenues for psychosis, depression, and other psychiatric diseases.
Analytical Genomics of Vulnerable Populations
Our lab focuses on understudied psychiatric disorders affecting women, children, and vulnerable populations.
Brain and Data Sciences Laboratory
We use predictive models that elucidate mechanisms and prioritize targets for drug development, as well as multiscale datasets generated from genomics, neurophysiology, neuroimaging, neuromodulation, and deep clinical assessment.
We study schizophrenia by reprogramming skin samples into pluripotent stem cells, which are later differentiated into human neurons.
Buxbaum Laboratory (Laboratory of Molecular Neuropsychiatry)
Our lab investigates human psychiatric and neurological diseases using genetics, genomics, cell and molecular biology, and animal models.
Computational Psychiatry Unit
We examine the neural and computational mechanisms underlying human beliefs, emotions, decision making, and social interaction through a synthesis of neuroscience, cognitive science, and behavioral economics.
Our team uses EEG and MRI to study reward sensitivity (both drug- and non-drug-related) and emotion dysregulation in drug addiction.
Experimental Psychopathology Lab
We study cognitive, affective, and behavioral processes and their link to psychopathology.
Using high-field and multimodal imaging, our lab examines the neurobiology of schizophrenia and bipolar disorders, and the effect of genetic and environmental factors.
Functional Neurogenomics Lab
Our research focuses on gene expressions in neuropsychiatric illnesses including schizophrenia, Alzheimer’s disease, and bipolar disorder.
Galynker Suicide Research Lab
Our lab investigates the psychological processes behind suicidal behavior.
We study the neurobiology and treatment of eating, weight, and body image disturbance. We use a mixture of neuroimaging, psychophysiology, neurocognitive, and endocrine assays as well as integrated technology solutions to create new treatments.
Our lab examines the neurobiology of underlying drug abuse and related psychiatric disorders.
We study how language can provide clues about psychosis in at-risk patients.
Our team studies the factors that help determine levels of brain plasticity and cognition in the sphere of perceptual development.
We use animal models of these disorders to identify the ways in which long-term exposure to drugs of abuse or stress changes the brain to lead to addiction- or depression-like syndromes.
Our team investigates physiological models in psychiatry.
Perinatal Health and Affective Neuroscience Lab
Our lab uses neuroscience to study the role of maternal prenatal stress in mother-infant outcomes.
Pinto Lab (Laboratory of Genomics of Neuropsychiatric Disease)
Our research identifies risk genes and biological pathways for neurodevelopmental disorders, including autism, epilepsy, schizophrenia, and Rett syndrome-like phenotypes.
Population Research and Environmental Epidemiology Lab
We conduct research studies in epidemiology to identify biomarkers of psychiatric disorders.
Psychiatry and Immunology Lab
Our team investigates how microglia, the immune cells of the brain, contribute to healthy brain development as well as the origin of neurodevelopmental disorders.
Our lab uses rodent model systems to understand behavioral, learning, and memory systems in Alzheimer’s disease.
Psychosocial Neuroimmune Addiction Lab
We investigate the neuroimmune and psychosocial pathways to disease and recovery in drug addiction.
The Quantitative Biometrics Lab
Our lab is an immersive mood, motor, cognitive, and neural assessment for deep brain stimulation candidates. The mission is to build tools to systematically integrate treatments for the mind with treatments for the brain, enhancing the lasting benefits of both.
Reproductive Psychiatry Lab
Our team studies psychiatric illness in perinatal women.
Robakis Laboratory (Laboratory of Molecular Biology and Genetics of Neurodegeneration)
We research the roles and processes of molecular biology and genetic neurodegeneration in specific diseases.
Our research focuses on identifying the epigenetic basis of neurodegenerative and psychiatric disorders. We study how miRNAs and histone modifying enzymes contribute to the establishment and maintenance of neuronal identity and specialized functions
We investigate the neural mechanisms underlying emotional control and flexibility, researching neuroplasticity and behavior.
Our lab studies complex trait genetics and the inference of genetic architecture through analysis of both common and rare variant genomic data as well as integration with other genomic and phenotypic data.
Translational Psychiatry Laboratory
Our team uses clinically relevant animal models of psychiatric pathology combined with data from human subjects to better understand the neurobiology underlying psychiatric pathologies.
We investigate the molecular endocrinology and neurobiology of PTSD; biomarker development for the detection of PTSD risk, diagnosis, and recovery; treatment innovation for PTSD; and brain mechanisms associated with symptoms and remission.