At the Department of Oncological Sciences, we have creative investigators from a broad variety of disciplines who are focused on the genetic, biochemical, cellular, and physiological underpinnings of cancer. Our goal is to better understand the disease in order to improve its diagnosis and treatment. We are committed to training the next generation of scientists.
Our research includes investigation of signaling pathways involved in cancer, oncogenes and tumor-suppressor genes, cell cycle regulation tumor invasion and metastasis, regulation of protein stability, tumor microenvironment including inflammation, angiogenesis, and lymphangiogenesis, cancer immunology, as well as novel cancer therapeutics and resistance mechanisms. Primary and joint investigations aim to achieve the following goals:
- A molecular understanding of the cellular processes and signaling pathways involved in the initiation and progression of human cancers
- Insights into molecular targets for innovative therapeutics
Our research themes address a wide variety of topics:
- Receptor and cytoplasmic regulatory pathways, including tyrosine kinase receptors, G proteins, Wnt ligands, cytokines, interleukin, interferon, and TGF beta
- Oncogenes and tumor-suppressor genes with implications for cell cycle regulation, apoptosis, growth arrest, and senescence
- Cell adhesion, including catenins and cadherins and altered signaling in metastasis
- Regulation of protein stability, including studies on the role of bTRCP and its components in the regulation of b-catenin, IkB stability, and Hlf1, and the regulation and functional significance of protein sumoylation
- Structural and macromolecular interactions in signaling pathways using X-ray crystallography and nuclear magnetic resonance technology
The Tisch Cancer Institute Seminar Series
The Tisch Cancer Institute weekly seminars are led by research scientists in the field and focus on emerging or current topics related to cancer. Faculty, postdocs, staff, and students gather to hear and learn from the scientist expert and share insights on cancer research. Attend an upcoming seminar
Supportive Climate: Report Misconduct
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