Cancer Biology

Our goal for the Cancer Biology (CAB) training area is to foster your growth as a committed scientist, skilled in the molecular and cellular biology of this disease group. We guide you on your path to pursuing a long-term career in cancer research. Our themes include cancer gene signaling pathways, development and differentiation, invasion and metastasis, as well as disease focuses including breast cancer, prostate cancer, leukemia, and melanoma. Our program also trains you in approaches aimed at translational research advances to the clinic, including advanced coursework in both basic and clinical cancer biology. CAB is a multidisciplinary training area (MTA) in the Graduate School of Biomedical Sciences at Icahn School of Medicine at Mount Sinai (ISMMS).

Cancer biology is the anatomical and physiological investigation of cancer cells and processes that lead to the initiation and progression of the disease. Cancer biologists investigate genome integrity; growth factor signaling; cell fate pathways including apoptosis; invasion and metastasis; and immune surveillance of cancer cells. 

Our curriculum trains you to be a skilled molecular and cellular biologist, able to pursue a career in cancer research. You will study cancer gene signaling pathways, development and differentiation, invasion and metastasis, and focus on diseases such as breast or prostate cancer, leukemia and melanoma.

We invite students from a variety of different backgrounds into our PhD programs. Working closely with our diverse faculty, we welcome your different perspectives as we integrate them into our solid academic research in cancer biology. Our students conduct research that is both comprehensive in scope and which addresses the practical clinical issues faced by physicians in preventing and treating cancer.

Students of our Cancer Biology training area are widely published early in their academic and professional careers.

Meet Our Co-Directors

Martin Walsh, PhD, is a Professor in the Department of Pharmacological Sciences, Genetics and Genomics Sciences and Pediatrics at ISMMS, and serves as a Co-Director of the Cancer Biology MTA. His research focuses on prostate, colon and breast cancer, using both patient-based genomic, epigenomic and transcriptomic data analysis and mouse genetics approaches, to investigate the underlying epigenetic and chromatin-biological mechanisms that alter the transcriptional and post-transcriptional controls leading changes in cell fates driving oncogenesis. Most recently, Dr. Walsh has worked on epigenetic factors that regulate the activities of extra chromosomal DNA (ecDNA) and their switch to HSR in altered chromosomes directing tumor cell diversification, their evolving resistant to therapies and potential for metastatic disease.

James J. Manfredi, PhD, is a Professor in the Department of Oncological Sciences and Co-Director of the Cancer Biology MTA. His research focuses on the molecular biology of the tumor suppressor p53 and how the p53 pathway can be used exploited to enhance cancer therapy.

Meet Our Faculty

Meet the accomplished faculty members of the Cancer Biology Graduate Training Area. 

We provide an educational environment that encourages rigorous science, open minded investigation, and measured risk taking. You will participate in conferences that tap into the superb clinical resources at ISMMS as you collaborate with students, trainees, and faculty to develop deeper understandings, make new discoveries and develop new models for treating cancer. Our training area allows for a personalized approach to cancer biology, as you engage in team efforts to make scientific advances.