The multidisciplinary training area in Pharmacology and Therapeutics Discovery provides cutting-edge training at the intersection between computation and experiments, to train you as part of our next generation of physicians and biomedical scientists. We facilitate discovery and development of chemical probes to study the pathophysiology of human diseases, aiming at new therapeutics and personalized medicine. We are a multidisciplinary training area in the PhD in Biomedical Sciences Program.
Pharmacology and Therapeutics Discovery
Faculty in the Pharmacology and Therapeutics Discovery training area research all steps in the drug development process, including structure-based identification of drug targets, computer-aided drug design, rationale synthesis of small molecules, disease mechanisms, characterization of drug effects in cellular and animal models, and systems pharmacology predictions using multiscale mathematical models.
Our personalized curriculum has been designed for our diverse student body, to help you obtain rigorous training at the junction of computation and experimentation.
We welcome students from both traditional and nontraditional paths into the PhD program. Our students have undergraduate degrees in mathematics, physics, computer science, engineering, chemistry, biochemistry, biology, pharmacology, genetics, and many other subjects. If you come to us with a more biological background, you will have the opportunity to obtain rigorous training in biophysical, chemical, and computational approaches to biological research. If yours is a more technical background, you will be getting your first sustained exposure to biological research during your PhD training at the Graduate School of Biomedical Sciences.
Students of our Pharmacology, Therapeutics and Discovery training area are widely published early in their academic and professional careers.
Meet Our Co-Directors
Avner Schlessinger, PhD, is an Assistant Professor of Pharmacological Sciences. The overall goal of Dr. Schlessinger’s lab is to improve and automate the drug discovery process by developing novel computational methods, and to apply these methods to characterize disease-related signaling and membrane proteins. His lab publishes in the areas of chemical biology, bioinformatics, and drug discovery, as well as in personalized medicine and pharmacogenomics.
Eric Sobie, PhD, is the Senior Associate Dean for Programmatic Development and Professor of Pharmacological Sciences. Dr. Sobie's lab, Sobie Laboratory, combines mathematical modeling with state-of-the-art experimental techniques in order to improve our quantitative understanding of cardiac physiology. Dr. Sobie's lab generates predictions using mathematical models, then test these predictions experimentally by measuring calcium and transmembrane voltage in heart cells. This provides novel insight into the initiation of arrhythmias and dysfunction that occurs in disease states such as heart failure.
Meet Our Faculty
Meet the accomplished faculty members of the Pharmacology, Therapeutics and Discovery Training Area.
Explore the many areas of research that our faculty and students are active in.
We provide an educational environment in Pharmacology and Therapeutics Discovery (PTD) that fosters all the training you need to discover and design new drug-like molecules that can modulate the function of biological systems.
You will gain a thorough understanding of drugs and drug targets under investigation using a variety of approaches ranging from structural, computational, molecular, and cell biology to biochemistry and synthetic chemistry. As a student in PTD, you also gain a deep understanding of biological systems and disease states through training that emphasizes a quantitative, predictive understanding of physiology, pharmacology, organ-level research, and animal studies.
Technology-based approaches we use in PTD research laboratories include: X-ray crystallography, NMR spectroscopy, electron microscopy, mass spectrometry, single-molecule imaging, chemical synthesis, proteomics, molecular modeling, bioinformatics, molecular dynamics simulations, mathematical modeling, next generation sequencing, cheminformatics, virtual screening, and other rational drug discovery methods.
After completing training in PTD, our graduates become leaders in academic laboratories, in the pharmaceutical and biotech industries, and with regulatory agencies.