Research conducted using human post-mortem brain tissue remains a critical component of translational brain research programs. To meet the urgent need for this precious resource, the Neuropathology Brain Bank and Research CoRE was launched as part of the Mount Sinai Strategic Plan in July 2018.
The Neuropathology Brain Bank & Research CoRE, now also encompassing the NIH-funded Alzheimer’s Disease Research Center Neuropathology Core at Mount Sinai, has the goal to strengthen and expand tissue-based translational research of devastating brain diseases by expanding the infrastructure to accelerate collection, characterization, and distribution of tissue and data to physician scientists and basic researchers.
Led by John F. Crary, MD-PhD, the core was formally established in July 2018 and has two complementary components. First, the research core provides a fully functional neuropathology-focused histology core service to Mount Sinai and external investigators, including routine and special stains, as well as RNAScope and BaseScope. Second, the brain bank is focused on expanding collections of targeted areas, including aging, neurodegenerative disorders (e.g. Parkinson’s disease, atypical parkinsonism, Alzheimer’s disease, frontotemporal dementia, and other movement disorders), traumatic brain injury, and COVID-19 encephalopathy.
The Neuropathology Brain Bank is proud to collaborate with the following research centers/initiatives:
- Alzheimer’s Disease Research Center (ADRC)
- CurePSP
- Rainwater Charitable Foundation
- Deane Center for Wellness and Cognitive Health at Mount Sinai
- James J. Peters Veterans Affairs Medical Center
- Neuroacanthocytosis Advocacy USA
- Parkinson’s Disease Foundation
- Brain Injury Research Center at Mount Sinai
- CTE Center at Boston University