Over the last three decades, there has been unprecedented progress in the study of the brain. State-of-the-art brain imaging has allowed a first-time glimpse into the structure, functioning, and connectivity of the human and animal brain in both healthy and disease states—findings of broad relevance across medical research and clinical programs.
The Translational and Molecular Imaging Institute (TMII) and The Friedman Brain Institute are working to accelerate use of these cutting-edge imaging tools to further research into the workings of the brain. One of these tools, known as the Brain Imaging Core, is designed to enhance research efforts within and outside the institution by providing investigators with high-level expertise in the collection and analysis of precise structural and functional images of living brains. At the Brain Imaging Center, we also are a research leader in developing a dynamic map of the shared and distinct mechanisms involved in the brain's complex functioning in both healthy brains and brains affected by a range of neuropsychiatric diseases.
Areas of Research
Our research is focused on a number of different areas:
- Brain morphology, function, and microstructure
- Resting and task-based functional connectivity
- Brain chemistry, metabolism, and physiology
- Multimodal imaging
- Development of novel imaging techniques
- Identifying neuropsychological mechanisms including at-risk endophenotypes
- Big data, data mining, computational modeling, and comparative studies
Advances in Research
The Translational and Molecular Imaging Institute provides BIC-affiliated laboratories with cutting-edge, optimized neuroimaging tools, supported by advanced study design and analysis expertise. The standardized imaging protocol offers participating researchers a simple and well-supported process for inclusion of structural and functional brain imaging in their investigations. Affiliated scientists are also able to draw on the comparative value afforded by the emerging BIC neuroimaging dataset for data mining and computational modeling.
Rita Z. Goldstein, PhD, Professor of Psychiatry and Neuroscience, and BIC's Chief, envisions a growing number of BIC-affiliated laboratories, spanning multiple departments at the Icahn School of Medicine at Mount Sinai, with shared interests that cross both departmental and institutional lines. For our investigators, as well as those at collaborating research institutions, we can provide a standardized and well-characterized set of brain scans, pipelined with a common protocol for pre-processing and analysis. The availability of established and expertly supported modalities for high-resolution brain imaging across research areas of interest will provide reliable, relatable information about brain morphology, function, and microstructure, as well as information about resting-based and task-based functional connectivity in healthy brains and brains affected by disease.