Icahn Genomics Institute

Services and Products

RNA NanoCore, a Core Facility of the Icahn Genomics Institute (IGI), provides a variety of services and products to assist researchers in pursuing their investigations. They are available to researchers both within and outside of the Icahn School of Medicine at Mount Sinai.

Services

RNA NanoCore offers a wide range of services tailored to meet the diverse needs of researchers in various fields. Key offerings include:

  1. Customized Lipid Nanoparticle (LNP) Synthesis: Production of lipid nanoparticles tailored to specific research requirements, including for in vitro and in vivo delivery of mRNA and CRISPR gRNA.
  2. RNA Production and Optimization: Synthesis and optimization of RNA molecules for various applications, including vaccine development, CRISPR gene editing, and protein expression.
  3. Collaborative Research and Consultation: Our team is available for consultations, research projects, and technical support, enabling seamless integration of our services into your research endeavors.

We have advanced facilities and expert staff to ensure reliable production, characterization, and quality control of mRNA and lipid nanoparticle (LNP)-mRNA formulations. Our core is equipped with state-of-the-art technology to produce high-quality mRNA and LNP-mRNA formulations.

Our meticulous approach includes comprehensive optimization of sequences and structural elements, such as untranslated regions, to boost mRNA stability and translational efficiency. We employ purification technologies to eliminate residual components and byproducts, ensuring the production of high-quality IVT mRNA transcripts and LNP-mRNA formulations.

We are spearheading the development of new ionizable lipids and LNP-mRNA formulations, establishing platforms for mRNA synthesis, purification, and quality control. Our commitment to innovation is reflected in our ongoing efforts to bring the latest technologies to Mount Sinai and develop new formulations for a range of medical fields including cancer, infectious disease, and genetic disorders as well as cardiovascular disease.

Products

Reporter mRNA

We provide reporter mRNA for tracking delivery efficiency and/or duration of expression in vitro and in vivo. Our IVT mRNA resembles fully mature mRNA with 5’ cap, UTR, and 3’ polyA.

  • eGFP mRNA
  • mCherry mRNA
  • Luciferase mRNA
  • Cre mRNA

We can manufacture our catalog mRNA with modified nucleotides, such as N1-methylpseudouridine, or capping technologies such as CleanCap® AG analog, within 2-3 weeks. Please inquire for information.

Custom-made mRNA

We provide cloning services of DNA templates for custom-made mRNA sequence.

LNP/mRNA formulation

We provide LNP/mRNA formulations with different chemical compositions optimized for specific applications and tissues of interest.

  • SM-102 LNP
  • ALC-0315 LNP
  • GenVoy LNP

We also provide customized LNP with other ionizable lipids and/or mRNA for specific application. We invite you to explore the services that our facility can offer to your academic pursuits. Whether you are working on experimental research projects, drug development, or vaccine design, our expertise and services are at your disposal.

Please contact us at nanocore@mssm.edu for additional product information.