Stem Cell Engineering CoRE

The mission of the Stem Cell Engineering CoRE (or SCEC) is to support researchers across different departments to implement human models into their research programs.

The SCEC is centrally located in the Institute for Regenerative Medicine and the Black Family Stem Cell Institute, in Icahn Building 13th floor; it also has a laboratory for cell production and gene editing in the Discovery and Innovation Center in Midtown West. The SCEC provides human pluripotent stem cell (PSC) lines, as well as laboratory space, validated reagents, and hands-on training for scientists.

Services include iPSC generation from somatic cells such as blood and fibroblasts, extensive characterization, and long-term banking. We also provide access to well-characterized iPSC lines derived from both healthy individuals and patients with diverse diseases, spanning different ethnic backgrounds and sexes. A major focus of the SCEC is gene editing in PSCs, offering a wide range of CRISPR-based services—from point mutation knock-in (correction or introduction) to the generation of reporter PSC lines (e.g., GFP or other reporters), as well as inducible systems such as Cre-lox, dTAG, and more. In addition, the Core provides assistance with differentiation protocols of PSCs into various cell types, both in monolayer cultures and in 3D organoid systems.

Reserve iLab Explore the Marro Lab

Meet the Stem Cell Engineering CoRE Team

Samuele Marro, PhD

Director

LAURA GRISANTI

Assistant CoRE Operations Manager

ERDENECHIMEG BALJINNYAM

Senior CoRE Scientist

PRIYA PRADHAN

Core Research Associate I

TATTARI SHALINI

Core Research Associate I

Stem Cell Engineering CoRE Overview

The Stem Cell CoRE offers a two-week basic training for users new to stem cells to learn iPSC key culture techniques. We also provide advanced training in iPSC differentiation into neuronal, hematopoietic, and cardiac lineage.

The Stem Cell CoRE organizes lectures on technical approaches and recent advances in the stem cell field. Follow the CoRE’s mailing list to receive the latest updates.

The Stem Cell Engineering Core (SCEC) is registered with the Research Resource Identifier (RRID) Portal, providing a unique and permanent digital identifier that ensures transparency, reproducibility, and proper acknowledgment of the Core’s contribution to scientific research.

RRID: RRID:SCR_027503
Official resolver link: https://scicrunch.org/resolver/RRID:SCR_027503

How to Cite the SCEC

When using services, iPSC lines, or other resources provided by the SCEC, please include the RRID in your publication’s Acknowledgments or Methods section.

Example citation:

Experiments were supported by the Stem Cell Engineering Core (RRID:SCR_027503) at the Icahn School of Medicine at Mount Sinai.

Example (Vancouver style):

Resources were provided by the Stem Cell Engineering Core (1).

RRID:SCR_027503. Stem Cell Engineering Core, Icahn School of Medicine at Mount Sinai. Available from: https://scicrunch.org/resolver/RRID:SCR_027503

Why Cite the SCEC RRID

Promotes reproducibility by linking your study to specific shared resources
Ensures proper attribution to the Core and its personnel
Supports institutional reporting and sustained funding for Core operations

The Stem Cell Engineering Core (SCEC) provides tissue culture equipment to support short- to medium-term projects carried out in collaboration with the Core. After training, users may access a fully equipped biosafety cabinet and tissue culture incubator. Additional specialized equipment is available for reservation through our iLab page.

Multielectrode Array (MEA) System (Maestro Pro) – The Maestro Pro (Axion Biosystems) is an advanced MEA platform that enables real-time, noninvasive recording of extracellular field potentials (EFPs) from iPSC-derived neurons or cardiomyocytes. This technology allows sensitive detection of drug-induced electrophysiological effects without the need for dyes, making it an essential tool for studying neuronal and cardiac physiology, disease modeling, and drug discovery. The SCEC maintains the Maestro Pro for community use; the instrument is located in Icahn 13-35 and must be booked through iLab.
Stem Cell Reagents and Small Molecules – The SCEC offers a selection of stem cell–qualified reagents and small molecules for purchase to support your research. Please visit iLab for details on available products and ordering information.