Students in the Disease Mechanisms and Therapeutics training program will spend a substantial amount of time working with our investigators and dedicated to research.

Lab Name Description
Aggarwal Lab Uncovering how enzymes and transcriptional and translational regulators interact with nucleic acids to affect cellular development and disease outcome
Akar Laboratory Investigating arrhythmia mechanisms in structural heart disease at multiple levels of integration
Azeloglu Laboratory Understanding role of mechanobiology in kidney disease using integrative experimental and computational methods
Bansal Laboratory Focusing on the role of Matrix Metalloproteinase-2 in liver fibrosis and regeneration and Role of the chemokine receptors, CXCR4 and CCR5, on stellate cell biology and fibrogenesis
Bashir Laboratory Researching bioinformatics/computational biology topics, primarily on problems related to genomic architecture
Blitzer Laboratory Studying cellular mechanisms giving rise to stable forms of synaptic plasticity in the brain, especially signaling pathways that regulate protein synthesis following synaptic stimulation
Campbell Laboratory Utilizing cell-based assays and rodent models to identify and characterize key mediators of glomerular disease progression
Chaudhry Laboratory Focusing on cell cycle regulation of cardiomyocytes and endogenous progenitor cells in the heart
Benjamin Chen Laboratory Investigating the biology of HIV assembly and viral infection through virological synapses
Shu-Hsia Chen Laboratory Exploring the activation of innate and adaptive immunity
John Cijiang He Research Studying the role of HIPK2 in kidney fibrosis
Costa Laboratory Focusing on cell cycle regulation of cardiomyocytes and endogenous progenitor cells in the heart
Dar Laboratory Exploring links between the regulation of drug targets and the system level properties of biological networks within cells and animals
DeVita Research Group Focused on drug discovery to meet the needs of patients for whom there are limited therapeutic options
Devi Laboratory Exploring the molecular mechanisms and functional implications of opioid receptor dimerization, and focusing on drug discovery to meet the needs of patients who have limited therapeutic options
Evan Flatow Research Conducting research in biomechanics/bioengineering, signal transduction, tendon biology, and tendon disease
Filizola Laboratory Engaging in computer-aided structural bio and drug design
Friedman Laboratory of Liver Research Researching the role of KLF6 in cell growth and human cancer, as well as molecular regulation of hepatic fibrosis
Gelb Research Group Focusing on disease gene discovery using genomic techniques and characterization of the biological roles of such genes in disease pathogenesis
Han Laboratory Identifying neurophysiological basis of susceptibility and resilience to chronic stress at molecular (ion channel and receptor) and cellular levels
Iyengar Laboratory Exploring how signals are routed and processed through cellular signaling networks, including information sorting and integration mechanisms
Jin Laboratory Discovering chemical probes for histone methyltransferases (HMTs) and creating functionally selective ligands of G protein-coupled receptors
Kenny Laboratory Researching applications in behavioral and molecular neuroscience
Lebeche Laboratory Targeting molecular and cellular pathways to improve contractile function and survival in failing cardiac myocytes
Ma’ayan Laboratory Applying computational and mathematical methods to study the complexity of regulatory networks in mammalian cells
Maze Laboratory Exploring the role of chromatin dynamics, nucleosomal turnover, and histone variant exchange in the central nervous system during periods of transcriptional, synaptic, and behavioral plasticity
Garcia-Ocana Research – Diabetes, Obesity and Metabolism Institute (DOMI) Focusing on tissue regeneration, growth factors, and intracellular signaling
Orthopedics Research Laboratory Using multidisciplinary approaches to address fundamental questions in the field of orthopaedic research
Roman Osman Research Studying proteolysis by integral membrane proteins,and blocking antigen presentation in autoimmunity and targeting MAGE inhibition of apoptosis
Palese Laboratory Focusing on fundamental questions concerning the genetic make-up and biology of viruses, as well as virus-host interactions
Parekh Laboratory Working to decipher the interplay between PDEs and synaptic responsiveness
Paisan-Ruiz Laboratory Studying Mantle Cell Lymphoma (MCL), a rare and usually fatal subtype of non-Hodgkin’s lymphoma, in collaboration with a Phase II clinical trial at the NIH
Parsons Laboratory Identifying the underpinnings of cancer and to using this information to improve prevention and treatment
Reddy Laboratory Studying genes that control cell homeostasis and how these controls are dysregulated during the neoplastic process
Lisa Satlin Research Defining the mechanisms leading to the acquisition, maintenance and regulation of transepithelial transport in the mammalian cortical collecting duct
Schaniel Laboratory Researching integrated stem cell biology; genomics; regenerative biology; and pharmacology Reprogramming, disease modeling and therapeutics with pluripotent stem cells
Schlessinger Laboratory Developing and applying novel computational approaches and collaboratively characterizing proteins that may be pharmacologically important in future cancer therapies
Donald Scott Research - Diabetes, Obesity and Metabolism Institute (DOMI) Working on the nutritional regulation of cellular phenotype
Sealfon Laboratory Using diverse systems biology approaches to study and model the mechanisms of cellular decoding of extracellular stimuli
Sobie Laboratory Increasing a fundamental understanding of how calcium signaling in heart cells interacts with and influences the heart’s electrical and mechanical functions
Andrew Stewart Research Striving to understand and develop novel means for inducing the replication and regeneration of insulin-producing pancreatic beta cells
Vasavada Laboratory - Diabetes, Obesity and Metabolism Institute (DOMI) Researching the pathways and mechanisms that regulate beta cell growth, survival and function, with the ultimate objective being to enhance regeneration of functional beta cells in vivo
Martin Walsh Research Investigating applications in structural and chemical biology, genetic and genomic sciences
Yue Laboratory Delving into the molecular and cellular mechanisms of neurodegeneration that causes human