1. Disease Mechanisms and Therapeutics
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Students in the Disease Mechanisms and Therapeutics multidisciplinary training area will spend an extensive amount of time working with our investigators and dedicated to research.

Meet the Co-Directors

Explore Our Labs

Aggarwal Lab 
Uncovering how enzymes and transcriptional and translational regulators interact with nucleic acids to affect cellular development and disease outcome.

Akar Lab
Investigating arrhythmia mechanisms in structural heart disease at multiple levels of integration.

Azeloglu Lab
Understanding the role of mechanobiology in kidney disease using integrative experimental and computational methods.

Bansal Lab
Focusing on the role of Matrix Metalloproteinase-2 in liver fibrosis and regeneration and role of the chemokine receptors, CXCR4 and CCR5, on stellate cell biology and fibrogenesis.

Bashir Lab 
Researching bioinformatics/computational biology topics, primarily on problems related to genomic architecture.

Blitzer Lab
Studying cellular mechanisms giving rise to stable forms of synaptic plasticity in the brain, especially signaling pathways that regulate protein synthesis following synaptic stimulation.

Campbell Lab
Utilizing cell-based assays and rodent models to identify and characterize key mediators of glomerular disease progression.

Chaudhry Lab 
Focusing on cell cycle regulation of cardiomyocytes and endogenous progenitor cells in the heart.

Benjamin Chen Lab 
Investigating the biology of HIV assembly and viral infection through virological synapses.

Shu-Hsia Chen Lab 
Exploring the activation of innate and adaptive immunity.

John Cijiang He Research
Studying the role of HIPK2 in kidney fibrosis.

Costa Lab 
Focusing on cell cycle regulation of cardiomyocytes and endogenous progenitor cells in the heart.

Dar Lab 
Exploring links between the regulation of drug targets and the system level properties of biological networks within cells and animals.

DeVita Research Group
Focused on drug discovery to meet the needs of patients for whom there are limited therapeutic options.

Devi Lab
Exploring the molecular mechanisms and functional implications of opioid receptor dimerization, and focusing on drug discovery to meet the needs of patients who have limited therapeutic options.

Evan Flatow Research
Conducting research in biomechanics/bioengineering, signal transduction, tendon biology, and tendon disease.

Filizola Lab
Engaging in computer-aided structural bio and drug design.

Friedman Lab of Liver Research
Researching the role of KLF6 in cell growth and human cancer, as well as molecular regulation of hepatic fibrosis.

Gelb Lab
Focusing on disease gene discovery using genomic techniques and characterization of the biological roles of such genes in disease pathogenesis.

Han Lab
Identifying neurophysiological basis of susceptibility and resilience to chronic stress at molecular (ion channel and receptor) and cellular levels.

Iyengar Lab
Exploring how signals are routed and processed through cellular signaling networks, including information sorting and integration mechanisms.

Jin Lab
Discovering chemical probes for histone methyltransferases (HMTs) and creating functionally selective ligands of G protein-coupled receptors.

Kenny Lab
Researching applications in behavioral and molecular neuroscience.

Lebeche Lab
Targeting molecular and cellular pathways to improve contractile function and survival in failing cardiac myocytes.

Ma’ayan Lab
Applying computational and mathematical methods to study the complexity of regulatory networks in mammalian cells.

Maze Lab
Exploring the role of chromatin dynamics, nucleosomal turnover, and histone variant exchange in the central nervous system during periods of transcriptional, synaptic, and behavioral plasticity.

Orthopedics Research Lab
Using multidisciplinary approaches to address fundamental questions in the field of orthopedic research.

Roman Osman Research 
Studying proteolysis by integral membrane proteins, and blocking antigen presentation in autoimmunity and targeting MAGE inhibition of apoptosis

Palese Lab
Focusing on fundamental questions concerning the genetic makeup and biology of viruses, as well as virus-host interactions.

Parekh Lab
Studying the contribution of genetic and epigenetic variation to aberrant gene expression in B cell malignancies.

Paisan-Ruiz Lab 
Studying mantle cell lymphoma, a rare and usually fatal subtype of non-Hodgkin’s lymphoma, in collaboration with a Phase II clinical trial at the NIH.

Parsons Lab
Identifying the underpinnings of cancer and using this information to improve prevention and treatment.

Reddy Lab
Studying genes that control cell homeostasis and how these controls are dysregulated during the neoplastic process.

Lisa Satlin Research
Defining the mechanisms leading to the acquisition, maintenance, and regulation of transepithelial transport in the mammalian cortical collecting duct.

Schaniel Lab
Researching integrated stem cell biology; genomics; regenerative biology; and pharmacology reprogramming, disease modeling, and therapeutics with pluripotent stem cells.

Schlessinger Lab
Developing and applying novel computational approaches and collaboratively characterizing proteins that may be pharmacologically important in future cancer therapies.

Donald Scott Research-Diabetes, Obesity and Metabolism Institute
Working on the nutritional regulation of cellular phenotype.

Sealfon Lab 
Using diverse systems biology approaches to study and model the mechanisms of cellular decoding of extracellular stimuli.

Sobie Lab 
Increasing a fundamental understanding of how calcium signaling in heart cells interacts with and influences the heart’s electrical and mechanical functions.

Stewart Lab
Striving to understand and develop novel means for inducing the replication and regeneration of insulin-producing pancreatic beta cells.

Vasavada Lab-Diabetes, Obesity and Metabolism Institute (DOMI) 
Researching the pathways and mechanisms that regulate beta cell growth, survival and function, with the ultimate objective being to enhance regeneration of functional beta cells in vivo.

Martin Walsh Research 
Investigating applications in structural and chemical biology, genetic and genomic sciences.

Yue Lab
Delving into the molecular and cellular mechanisms of neurodegeneration that causes human.