You can get the JYNNEOS vaccine at the same time as most vaccines including the flu, human papilloma virus (HPV), hepatitis A, hepatitis B, meningococcal, and herpes zoster (shingles) vaccines.
You can also get the JYNNEOS vaccine before, after, or at the same time as the COVID-19 vaccine. However, people at increased risk of myocarditis (inflammation of the heart), particularly males ages 12 to 39, should consider waiting four weeks between getting the JYNNEOS and COVID-19 vaccines. This is because there is a rare risk of developing myocarditis after COVID-19 vaccination. JYNNEOS clinical trials did not show an increased risk of myocarditis following vaccination.
If you know you were exposed to mpox, you should not delay getting the JYNNEOS vaccine, even if you recently got a COVID-19 vaccine.
For others, in deciding whether to delay getting either vaccine, consider your risk of exposure and risk of severe illness from COVID-19 and mpox. Talk to your health care provider if you have questions about timing of vaccination.
Are There Side Effects of the Vaccine?
Common side effects of the JYNNEOS vaccine include:
- Muscle pain
- Redness, swelling, soreness, and itchiness at the site of injection.
Generally, the injection-site side effects from an intradermal injection are worse and last longer than those from a subcutaneous injection. Intradermal injections can result in long-term or permanent scarring, discoloration and thinning of the skin at the injection site. The risk for these types of reactions is higher for people with darker skin. People will be asked at the vaccination site whether they have a history of keloid scars, and those who do will be offered subcutaneous administration.